OR2M3

Summary

OR2M3 (olfactory receptor family 2 subfamily M member 3, HGNC:8269) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2M3 (Q8NG83). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127062 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_001004689

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8269
Approved symbol	OR2M3
Name	olfactory receptor family 2 subfamily M member 3
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	OST003
Ensembl gene	ENSG00000228198
Ensembl biotype	protein_coding
Entrez	127062

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000456743, ENST00000641626

RefSeq mRNA: 1 — MANE Select: NM_001004689 NM_001004689

CCDS: CCDS31107

Canonical transcript exons

ENST00000641626 — 2 exons

Exon	Start	End
ENSE00003811679	248197265	248197301
ENSE00003812478	248203050	248212925

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 55.09.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	55.09	gold quality
transverse colon	UBERON:0001157	48.70	gold quality
sural nerve	UBERON:0015488	48.25	silver quality
stromal cell of endometrium	CL:0002255	47.67	gold quality
rectum	UBERON:0001052	46.60	gold quality
endometrium	UBERON:0001295	45.96	gold quality
colonic epithelium	UBERON:0000397	45.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	44.58	gold quality
cortex of kidney	UBERON:0001225	42.63	silver quality
calcaneal tendon	UBERON:0003701	41.27	gold quality
colon	UBERON:0001155	41.18	gold quality
superior frontal gyrus	UBERON:0002661	41.00	gold quality
liver	UBERON:0002107	40.88	gold quality
monocyte	CL:0000576	40.58	gold quality
vermiform appendix	UBERON:0001154	40.12	gold quality
leukocyte	CL:0000738	39.88	gold quality
prefrontal cortex	UBERON:0000451	39.34	silver quality
primary visual cortex	UBERON:0002436	39.05	gold quality
skeletal muscle tissue	UBERON:0001134	38.82	gold quality
muscle tissue	UBERON:0002385	38.46	gold quality
intestine	UBERON:0000160	38.24	gold quality
bone marrow	UBERON:0002371	38.09	gold quality
bone marrow cell	CL:0002092	38.06	gold quality
lymph node	UBERON:0000029	37.75	gold quality
right lobe of liver	UBERON:0001114	37.34	gold quality
lower esophagus mucosa	UBERON:0035834	37.19	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
tonsil	UBERON:0002372	36.27	gold quality
blood	UBERON:0000178	35.76	gold quality
metanephros cortex	UBERON:0010533	35.56	silver quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-97	yes	2652.09
E-MTAB-6678	yes	1708.36
E-MTAB-5061	yes	14.72
E-ANND-3	yes	5.22
E-ENAD-20	no	63.53

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This work shows that the specific thiol function of human OR2M3 is modulated by copper ions. The homology modeling/docking studies together with receptor functional expression studies suggest that this copper sensitivity is mediated by two copper-binding sites within narrowly tuned OR2M3. (PMID:31435697)

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2M3 — Q8NG83 (reviewed: Q8NG83)

Alternative names: Olfactory receptor 2M6, Olfactory receptor OR1-54

All UniProt accessions (2): Q8NG83, A0A126GV67

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004689* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG83-F1	85.00	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

140 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2M3	IGHV3-72	A0A0B4J1Y9	418
OR2M3	RAX2	Q96IS3	396
OR2M3	BDH2	Q9BUT1	349
OR2M3	YPEL4	Q96NS1	349
OR2M3	NKAPL	Q5M9Q1	339
OR2M3	IGHV3-15	A0A0B4J1V0	334
OR2M3	IGHV3-11	P01762	322
OR2M3	S100A13	Q99584	315
OR2M3	CRLF1	O75462	312
OR2M3	BCL6B	Q8N143	311
OR2M3	DDX19A	Q9NUU7	300
OR2M3	THSD7B	Q9C0I4	300
OR2M3	SGSM2	O43147	297
OR2M3	TAS2R1	Q9NYW7	284
OR2M3	ADM2	Q7Z4H4	284

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	62
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

241 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248203703:A:AG	acceptor_gain	0.7900
1:248203704:A:G	acceptor_gain	0.6900
1:248204000:A:T	donor_gain	0.6500
1:248203808:G:GA	donor_gain	0.6200
1:248203076:G:GT	donor_gain	0.6100
1:248203677:AT:A	donor_gain	0.6100
1:248203991:C:T	donor_gain	0.6100
1:248203710:ATT:A	acceptor_gain	0.5800
1:248203334:C:T	donor_gain	0.5700
1:248203804:T:A	acceptor_gain	0.5600
1:248203721:T:G	acceptor_gain	0.5500
1:248203355:T:TA	donor_gain	0.5400
1:248203700:T:A	acceptor_gain	0.5400
1:248203710:A:AG	acceptor_gain	0.5300
1:248203766:T:TA	donor_gain	0.5300
1:248203534:G:GT	donor_gain	0.5100
1:248203712:T:TA	acceptor_gain	0.5100
1:248203939:GC:G	acceptor_gain	0.5100
1:248203984:G:GT	donor_gain	0.5100
1:248203938:A:AG	acceptor_gain	0.5000
1:248203939:G:GG	acceptor_gain	0.5000
1:248203333:G:GG	donor_gain	0.4900
1:248203707:A:AG	acceptor_gain	0.4900
1:248203874:A:AG	acceptor_gain	0.4900
1:248203932:A:AG	acceptor_gain	0.4900
1:248203332:A:AG	donor_gain	0.4800
1:248203679:A:AG	acceptor_gain	0.4800
1:248203680:G:GG	acceptor_gain	0.4800
1:248203683:A:AG	donor_gain	0.4800
1:248203720:AT:A	acceptor_gain	0.4800

AlphaMissense

2055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248203938:A:C	S291R	0.920
1:248203940:C:A	S291R	0.920
1:248203940:C:G	S291R	0.920
1:248203101:T:C	F12L	0.904
1:248203103:C:A	F12L	0.904
1:248203103:C:G	F12L	0.904
1:248203596:T:C	F177L	0.888
1:248203598:C:A	F177L	0.888
1:248203598:C:G	F177L	0.888
1:248203421:G:A	M118I	0.876
1:248203421:G:C	M118I	0.876
1:248203421:G:T	M118I	0.876
1:248203432:G:C	R122P	0.856
1:248203602:T:A	C179S	0.852
1:248203603:G:C	C179S	0.852
1:248203119:T:C	F18L	0.850
1:248203121:C:A	F18L	0.850
1:248203121:C:G	F18L	0.850
1:248203170:T:C	F35L	0.827
1:248203172:T:A	F35L	0.827
1:248203172:T:G	F35L	0.827
1:248203102:T:C	F12S	0.826
1:248203356:T:A	C97S	0.825
1:248203357:G:C	C97S	0.825
1:248203512:T:A	W149R	0.824
1:248203512:T:C	W149R	0.824
1:248203603:G:A	C179Y	0.824
1:248203599:T:C	F178L	0.823
1:248203601:C:A	F178L	0.823
1:248203601:C:G	F178L	0.823

dbSNP variants (sampled 300 via entrez): RS1000162512 (1:248212574 GT>G,GTT,GTTTTTTT), RS1000187836 (1:248213362 A>G), RS1000224649 (1:248210171 A>G), RS1000276926 (1:248210346 G>T), RS1000446157 (1:248195526 A>G), RS1000538701 (1:248200175 G>A), RS1000775932 (1:248208041 C>T), RS1000814448 (1:248205411 C>G,T), RS1001119110 (1:248205109 A>G), RS1001174024 (1:248202442 A>G), RS1001336614 (1:248197925 ATC>A), RS1001439206 (1:248207774 A>G), RS1001479296 (1:248198511 C>G), RS1001656900 (1:248208589 C>G,T), RS1001713903 (1:248203225 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases mutagenesis, affects methylation, increases methylation	2
butyraldehyde	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Endosulfan	increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.