OR2M5

Summary

OR2M5 (olfactory receptor family 2 subfamily M member 5, HGNC:19576) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2M5 (A3KFT3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127059 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 66 total
• MANE Select transcript: NM_001004690

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19576
Approved symbol	OR2M5
Name	olfactory receptor family 2 subfamily M member 5
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000162727
Ensembl biotype	protein_coding
Entrez	127059

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000366476

RefSeq mRNA: 1 — MANE Select: NM_001004690 NM_001004690

CCDS: CCDS31105

Canonical transcript exons

ENST00000366476 — 1 exons

Exon	Start	End
ENSE00002314277	248145148	248146086

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 93.29.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.29	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
prefrontal cortex	UBERON:0000451	30.25	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
urinary bladder	UBERON:0001255	29.15	gold quality
liver	UBERON:0002107	28.69	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.77	gold quality
monocyte	CL:0000576	26.69	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.33	gold quality
ectocervix	UBERON:0012249	26.01	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
frontal cortex	UBERON:0001870	25.28	gold quality
muscle of leg	UBERON:0001383	25.22	gold quality
pancreas	UBERON:0001264	24.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2M5 — A3KFT3 (reviewed: A3KFT3)

All UniProt accessions (1): A3KFT3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004690* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A3KFT3-F1	85.27	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

102 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2M5	KRTAP19-8	Q3LI54	474
OR2M5	PDZD8	Q8NEN9	392
OR2M5	KRTAP5-7	Q6L8G8	364
OR2M5	DOCK5	Q9H7D0	348
OR2M5	DPPA2	Q7Z7J5	306
OR2M5	LAMA3	Q16787	305
OR2M5	TAS2R42	Q7RTR8	305
OR2M5	KRTAP5-11	Q6L8G4	302
OR2M5	CCSER2	Q9H7U1	297
OR2M5	LLPH	Q9BRT6	296
OR2M5	KRTAP5-5	Q701N2	294
OR2M5	CYB561A3	Q8NBI2	276
OR2M5	LAMA4	Q16363	257
OR2M5	TAS2R16	Q9NYV7	247
OR2M5	GREB1L	Q9C091	228

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

294 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248145783:A:AG	acceptor_gain	0.8100
1:248145435:T:TA	donor_gain	0.7800
1:248145784:A:G	acceptor_gain	0.7400
1:248145414:C:T	donor_gain	0.6800
1:248145436:T:TA	donor_gain	0.6800
1:248146054:A:T	donor_gain	0.6800
1:248145888:G:GA	donor_gain	0.6600
1:248145846:T:TA	donor_gain	0.6500
1:248145757:AT:A	donor_gain	0.6400
1:248145763:A:AG	donor_gain	0.6400
1:248145790:ATC:A	acceptor_gain	0.6200
1:248146071:C:T	donor_gain	0.6200
1:248145413:G:GG	donor_gain	0.6000
1:248145780:T:TA	acceptor_gain	0.5900
1:248145829:AT:A	acceptor_gain	0.5900
1:248145887:T:TA	donor_gain	0.5900
1:248146033:G:GT	donor_gain	0.5900
1:248145792:C:CA	acceptor_gain	0.5800
1:248145894:A:T	donor_gain	0.5800
1:248145801:T:G	acceptor_gain	0.5700
1:248145412:A:AG	donor_gain	0.5500
1:248145847:C:CA	donor_gain	0.5500
1:248145890:TGGGA:T	donor_gain	0.5500
1:248145493:GCTGT:G	donor_gain	0.5400
1:248145870:T:TA	donor_gain	0.5400
1:248145760:GTAAT:G	acceptor_gain	0.5300
1:248145845:G:T	donor_gain	0.5300
1:248146053:G:GT	donor_gain	0.5300
1:248146065:A:T	donor_gain	0.5300
1:248145687:C:G	donor_gain	0.5200

AlphaMissense

2060 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248145181:T:C	F12L	0.832
1:248145183:C:A	F12L	0.832
1:248145183:C:G	F12L	0.832
1:248145676:T:C	F177L	0.793
1:248145678:C:A	F177L	0.793
1:248145678:C:G	F177L	0.793
1:248145250:T:C	F35L	0.790
1:248145252:T:A	F35L	0.790
1:248145252:T:G	F35L	0.790
1:248145679:T:C	F178L	0.745
1:248145681:C:A	F178L	0.745
1:248145681:C:G	F178L	0.745
1:248145199:T:C	F18L	0.731
1:248145201:C:A	F18L	0.731
1:248145201:C:G	F18L	0.731
1:248146018:A:C	S291R	0.726
1:248146020:C:A	S291R	0.726
1:248146020:C:G	S291R	0.726
1:248145976:T:C	F277L	0.679
1:248145978:C:A	F277L	0.679
1:248145978:C:G	F277L	0.679
1:248145730:T:C	F195L	0.677
1:248145732:T:A	F195L	0.677
1:248145732:T:G	F195L	0.677
1:248145643:T:C	F166L	0.673
1:248145645:C:A	F166L	0.673
1:248145645:C:G	F166L	0.673
1:248145451:T:C	F102L	0.663
1:248145453:C:A	F102L	0.663
1:248145453:C:G	F102L	0.663

dbSNP variants (sampled 300 via entrez): RS1001063673 (1:248144295 G>A,C), RS1002809149 (1:248146573 A>G), RS1003192272 (1:248146308 T>C), RS1005782307 (1:248143362 T>C), RS1006115820 (1:248144498 CA>C,CAA), RS1007027070 (1:248144022 T>A,G), RS1007249705 (1:248144530 G>A), RS1007408609 (1:248143820 C>T), RS1007629642 (1:248144351 G>A,C), RS1007771730 (1:248145146 T>A), RS1008300831 (1:248146185 C>A,T), RS1009837137 (1:248145206 A>G), RS1010199187 (1:248146290 A>C), RS1011751539 (1:248146409 G>A), RS1012851344 (1:248143865 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.