OR2M7

Summary

OR2M7 (olfactory receptor family 2 subfamily M member 7, HGNC:19594) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2M7 (Q8NG81). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 391196 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 68 total
• MANE Select transcript: NM_001004691

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19594
Approved symbol	OR2M7
Name	olfactory receptor family 2 subfamily M member 7
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177186
Ensembl biotype	protein_coding
OMIM	618509
Entrez	391196

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000317965

RefSeq mRNA: 1 — MANE Select: NM_001004691 NM_001004691

CCDS: CCDS31111

Canonical transcript exons

ENST00000317965 — 1 exons

Exon	Start	End
ENSE00002210392	248323630	248324568

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 97.54.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.54	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.93	gold quality
muscle tissue	UBERON:0002385	32.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
primary visual cortex	UBERON:0002436	29.46	silver quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
liver	UBERON:0002107	28.86	gold quality
monocyte	CL:0000576	28.40	silver quality
leukocyte	CL:0000738	28.33	silver quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.87	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.40	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
uterine cervix	UBERON:0000002	25.35	gold quality
muscle of leg	UBERON:0001383	25.06	gold quality
frontal cortex	UBERON:0001870	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2M7 — Q8NG81 (reviewed: Q8NG81)

Alternative names: Olfactory receptor OR1-58

All UniProt accessions (2): A0A126GVZ1, Q8NG81

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004691* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NG81-F1	85.28	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, HBZ_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

340 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2M7	SULT1C3	Q6IMI6	448
OR2M7	ZNF546	Q86UE3	438
OR2M7	MTA1	Q13330	427
OR2M7	LRRK2	Q5S007	378
OR2M7	RTP1	P59025	375
OR2M7	GSTZ1	O43708	374
OR2M7	ADD1	P35611	343
OR2M7	MAP4	P27816	319
OR2M7	TAS2R60	P59551	307
OR2M7	ADAM33	Q9BZ11	274
OR2M7	CSPP1	Q1MSJ5	272
OR2M7	SIRPB1	O00241	246
OR2M7	KRT83	P78385	232
OR2M7	BNC2	Q6ZN30	222
OR2M7	GRK3	P35626	221

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR2M7	MARCHF6	psi-mi:“MI:0914”(association)	0.350

BioGRID (21): ZC2HC1B (Affinity Capture-MS), DCAKD (Affinity Capture-MS), FADS1 (Affinity Capture-MS), OSBPL8 (Affinity Capture-MS), RHBDD1 (Affinity Capture-MS), EMC4 (Affinity Capture-MS), UBQLN4 (Affinity Capture-MS), GUCY1B3 (Affinity Capture-MS), EIF2AK3 (Affinity Capture-MS), PKMYT1 (Affinity Capture-MS), SQLE (Affinity Capture-MS), TAP1 (Affinity Capture-MS), ANKLE2 (Affinity Capture-MS), MARCH6 (Affinity Capture-MS), ERMP1 (Affinity Capture-MS)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

280 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248324302:G:A	donor_gain	0.8100
1:248323932:T:TC	acceptor_gain	0.7700
1:248323870:T:TA	donor_gain	0.7500
1:248323862:TTGCG:T	donor_gain	0.7400
1:248323763:A:C	acceptor_gain	0.7300
1:248323871:C:A	donor_gain	0.7200
1:248323759:C:CC	acceptor_gain	0.7000
1:248323682:T:TA	donor_gain	0.6900
1:248324302:G:GC	donor_gain	0.6900
1:248324303:C:CC	donor_gain	0.6900
1:248323955:A:AC	donor_gain	0.6700
1:248323755:TGTCC:T	acceptor_loss	0.6500
1:248323756:GTCCT:G	acceptor_loss	0.6500
1:248323757:TCCT:T	acceptor_loss	0.6500
1:248323759:CT:C	acceptor_loss	0.6500
1:248323760:T:A	acceptor_loss	0.6500
1:248323935:C:CT	acceptor_gain	0.6500
1:248323827:C:CT	donor_gain	0.6400
1:248323859:G:C	donor_gain	0.6400
1:248323922:G:GC	acceptor_gain	0.6300
1:248323936:A:T	acceptor_gain	0.6300
1:248323645:G:A	donor_gain	0.6200
1:248323828:C:CT	donor_gain	0.6200
1:248323866:G:GT	donor_gain	0.6200
1:248323915:A:C	acceptor_gain	0.6200
1:248323762:CA:C	acceptor_gain	0.6100
1:248323683:C:A	donor_gain	0.6000
1:248323822:T:A	donor_gain	0.6000
1:248323957:TA:T	donor_gain	0.6000
1:248323757:TC:T	acceptor_gain	0.5900

AlphaMissense

2064 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248324038:G:C	F177L	0.837
1:248324038:G:T	F177L	0.837
1:248324040:A:G	F177L	0.837
1:248324533:G:C	F12L	0.808
1:248324533:G:T	F12L	0.808
1:248324535:A:G	F12L	0.808
1:248323696:G:C	S291R	0.784
1:248323696:G:T	S291R	0.784
1:248323698:T:G	S291R	0.784
1:248324515:G:C	F18L	0.771
1:248324515:G:T	F18L	0.771
1:248324517:A:G	F18L	0.771
1:248324124:A:G	W149R	0.739
1:248324124:A:T	W149R	0.739
1:248324464:A:C	F35L	0.721
1:248324464:A:T	F35L	0.721
1:248324466:A:G	F35L	0.721
1:248324215:C:A	M118I	0.705
1:248324215:C:G	M118I	0.705
1:248324215:C:T	M118I	0.705
1:248324071:G:C	F166L	0.690
1:248324071:G:T	F166L	0.690
1:248324073:A:G	F166L	0.690
1:248323984:A:C	F195L	0.686
1:248323984:A:T	F195L	0.686
1:248323986:A:G	F195L	0.686
1:248324346:A:G	C75R	0.676
1:248324206:G:C	D121E	0.671
1:248324206:G:T	D121E	0.671
1:248324485:G:C	F28L	0.669

dbSNP variants (sampled 300 via entrez): RS1000691045 (1:248324969 C>T), RS1002365005 (1:248326550 C>A,T), RS1009501322 (1:248323358 T>G), RS1010349797 (1:248325325 G>T), RS1011569868 (1:248326437 A>T), RS1013493209 (1:248323256 T>C), RS1014176899 (1:248325876 C>T), RS1014886487 (1:248325401 A>G), RS1014938942 (1:248325735 T>C), RS10157089 (1:248324855 A>C,G,T), RS1018192228 (1:248325367 C>T), RS1018570549 (1:248324026 G>A,T), RS1018802344 (1:248323297 G>A), RS1020595366 (1:248326369 A>G), RS1021532208 (1:248326106 G>A)

Disease associations

OMIM: gene MIM:618509 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST000706_15	Common traits (Other)	7.000000e-24

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.