OR2T10

Summary

OR2T10 (olfactory receptor family 2 subfamily T member 10, HGNC:19573) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T10 (Q8NGZ9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127069 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_001004693

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19573
Approved symbol	OR2T10
Name	olfactory receptor family 2 subfamily T member 10
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000184022
Ensembl biotype	protein_coding
Entrez	127069

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000330500, ENST00000642090

RefSeq mRNA: 1 — MANE Select: NM_001004693 NM_001004693

CCDS: CCDS31121

Canonical transcript exons

ENST00000642090 — 2 exons

Exon	Start	End
ENSE00003812462	248590487	248593796
ENSE00003813021	248597492	248597700

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 56.43.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	56.43	gold quality
kidney	UBERON:0002113	53.04	gold quality
metanephros cortex	UBERON:0010533	51.37	gold quality
cortex of kidney	UBERON:0001225	47.98	gold quality
bone marrow cell	CL:0002092	42.22	gold quality
colonic epithelium	UBERON:0000397	41.81	gold quality
sural nerve	UBERON:0015488	41.33	gold quality
lymph node	UBERON:0000029	39.02	silver quality
superior frontal gyrus	UBERON:0002661	37.98	gold quality
placenta	UBERON:0001987	37.87	gold quality
monocyte	CL:0000576	37.25	gold quality
leukocyte	CL:0000738	36.89	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow	UBERON:0002371	35.92	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.41	gold quality
granulocyte	CL:0000094	35.39	gold quality
skeletal muscle tissue	UBERON:0001134	34.97	gold quality
apex of heart	UBERON:0002098	34.72	gold quality
muscle tissue	UBERON:0002385	34.36	gold quality
fallopian tube	UBERON:0003889	32.14	silver quality
right uterine tube	UBERON:0001302	31.84	gold quality
endometrium	UBERON:0001295	30.65	gold quality
liver	UBERON:0002107	30.58	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
vermiform appendix	UBERON:0001154	29.79	silver quality
spleen	UBERON:0002106	28.57	gold quality
left uterine tube	UBERON:0001303	28.43	gold quality
duodenum	UBERON:0002114	28.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.11

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T10 — Q8NGZ9 (reviewed: Q8NGZ9)

Alternative names: Olfactory receptor OR1-64

All UniProt accessions (2): Q8NGZ9, A0A126GV79

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004693* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGZ9-F1	88.41	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, CAMPS_COLON_CANCER_COPY_NUMBER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T10	ORMDL2	Q53FV1	571
OR2T10	NBPF19	A0A087WUL8	571
OR2T10	CYLC2	Q14093	505
OR2T10	CIMAP1D	Q3SX64	482
OR2T10	HHIPL2	Q6UWX4	447
OR2T10	SCNN1D	P51172	434
OR2T10	USP17L19	D6RCP7	432
OR2T10	USP17L15	C9J2P7	419
OR2T10	ARHGEF38	Q9NXL2	417
OR2T10	SHC2	P98077	395
OR2T10	RALGAPB	Q86X10	394
OR2T10	CCDC91	Q7Z6B0	370
OR2T10	MRPS16	Q9Y3D3	325
OR2T10	PABPC5	Q96DU9	317
OR2T10	MUC1	P13931	308

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR2T10	LETM1	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): RAP1A (Affinity Capture-MS), HRAS (Affinity Capture-MS), LETM1 (Affinity Capture-MS)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

336 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248592897:C:CC	acceptor_gain	0.7300
1:248592896:ACT:A	acceptor_gain	0.6700
1:248593670:A:AC	donor_gain	0.6700
1:248593671:C:CC	donor_gain	0.6700
1:248593123:C:CC	acceptor_gain	0.6300
1:248593130:G:T	donor_gain	0.6200
1:248593089:T:TC	acceptor_gain	0.6100
1:248593230:T:TG	acceptor_gain	0.6100
1:248593350:AC:A	donor_gain	0.6100
1:248593351:CC:C	donor_gain	0.6100
1:248593027:CCA:C	acceptor_gain	0.6000
1:248593028:CAC:C	acceptor_gain	0.6000
1:248593736:G:C	donor_gain	0.6000
1:248592897:CTGTA:C	acceptor_gain	0.5900
1:248593121:CA:C	acceptor_gain	0.5900
1:248593128:A:AC	donor_gain	0.5900
1:248593132:CCG:C	donor_gain	0.5900
1:248592893:GAAA:G	acceptor_gain	0.5800
1:248593740:C:CT	donor_gain	0.5800
1:248592896:AC:A	acceptor_loss	0.5700
1:248592897:C:G	acceptor_loss	0.5700
1:248592898:T:G	acceptor_loss	0.5700
1:248593089:T:C	acceptor_gain	0.5600
1:248593445:T:TA	donor_gain	0.5600
1:248592898:T:A	acceptor_gain	0.5500
1:248593593:A:C	donor_gain	0.5500
1:248592892:TGAAA:T	acceptor_gain	0.5400
1:248593089:T:TG	acceptor_gain	0.5400
1:248593741:C:CT	donor_gain	0.5400
1:248593077:A:C	donor_gain	0.5300

AlphaMissense

2055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248593022:G:C	S249R	0.907
1:248593022:G:T	S249R	0.907
1:248593024:T:G	S249R	0.907
1:248592896:A:C	S291R	0.887
1:248592896:A:T	S291R	0.887
1:248592898:T:G	S291R	0.887
1:248593016:G:C	F251L	0.881
1:248593016:G:T	F251L	0.881
1:248593018:A:G	F251L	0.881
1:248593415:C:A	M118I	0.853
1:248593415:C:G	M118I	0.853
1:248593415:C:T	M118I	0.853
1:248593265:G:C	F168L	0.847
1:248593265:G:T	F168L	0.847
1:248593267:A:G	F168L	0.847
1:248593238:G:C	F177L	0.846
1:248593238:G:T	F177L	0.846
1:248593240:A:G	F177L	0.846
1:248593404:C:G	R122P	0.844
1:248593733:A:C	F12L	0.844
1:248593733:A:T	F12L	0.844
1:248593735:A:G	F12L	0.844
1:248593324:A:G	W149R	0.834
1:248593324:A:T	W149R	0.834
1:248593235:G:C	F178L	0.832
1:248593235:G:T	F178L	0.832
1:248593237:A:G	F178L	0.832
1:248593413:G:T	A119D	0.830
1:248593327:A:G	C148R	0.826
1:248593407:T:G	D121A	0.826

dbSNP variants (sampled 300 via entrez): RS1000384653 (1:248594463 T>C,G), RS1000737600 (1:248591901 T>C), RS1001179846 (1:248591374 C>A,T), RS1002951264 (1:248598039 T>G), RS1003247366 (1:248595564 A>T), RS1003279874 (1:248595084 G>A,C), RS1004680974 (1:248596365 T>C), RS1005254555 (1:248590211 C>G,T), RS1006480017 (1:248590505 CAT>C), RS1006599615 (1:248591309 A>C), RS1006714229 (1:248590715 AT>A), RS1010500127 (1:248594925 TAA>T,TAAA,TAAAA), RS1010885695 (1:248595478 A>G), RS1011480950 (1:248598651 ATAAT>A), RS1011919544 (1:248597973 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
4-nonylphenol	affects cotreatment, increases expression	1
4-tert-octylphenol	affects cotreatment, increases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.