OR2T11

Summary

OR2T11 (olfactory receptor family 2 subfamily T member 11, HGNC:19574) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T11 (Q8NH01). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 127077 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_001001964

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19574
Approved symbol	OR2T11
Name	olfactory receptor family 2 subfamily T member 11
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	OR2T11Q
Ensembl gene	ENSG00000279301
Ensembl biotype	protein_coding
Entrez	127077

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641193

RefSeq mRNA: 1 — MANE Select: NM_001001964 NM_001001964

Canonical transcript exons

ENST00000641193 — 2 exons

Exon	Start	End
ENSE00003813431	248623557	248627272
ENSE00003814227	248635038	248635091

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 40.22.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	40.22	gold quality
bone marrow	UBERON:0002371	39.20	gold quality
kidney	UBERON:0002113	37.76	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
monocyte	CL:0000576	36.20	gold quality
adult mammalian kidney	UBERON:0000082	35.61	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.40	gold quality
sural nerve	UBERON:0015488	34.97	gold quality
skeletal muscle tissue	UBERON:0001134	34.70	gold quality
apex of heart	UBERON:0002098	34.65	gold quality
metanephros cortex	UBERON:0010533	33.46	silver quality
tonsil	UBERON:0002372	33.01	gold quality
lymph node	UBERON:0000029	32.30	gold quality
muscle tissue	UBERON:0002385	32.03	gold quality
blood	UBERON:0000178	32.01	gold quality
mucosa of stomach	UBERON:0001199	31.69	gold quality
placenta	UBERON:0001987	31.09	gold quality
prefrontal cortex	UBERON:0000451	30.01	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.73	gold quality
vermiform appendix	UBERON:0001154	29.20	gold quality
muscle of leg	UBERON:0001383	29.02	gold quality
urinary bladder	UBERON:0001255	28.77	gold quality
right uterine tube	UBERON:0001302	28.44	gold quality
gastrocnemius	UBERON:0001388	28.24	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T11 — Q8NH01 (reviewed: Q8NH01)

Alternative names: Olfactory receptor OR1-65

All UniProt accessions (1): Q8NH01

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001964* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH01-F1	88.73	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 94–186

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, CAMPS_COLON_CANCER_COPY_NUMBER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZNF7_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

172 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T11	FAM9C	Q8IZT9	507
OR2T11	ORMDL2	Q53FV1	480
OR2T11	KRTAP17-1	Q9BYP8	400
OR2T11	ZNF232	Q9UNY5	370
OR2T11	USP17L19	D6RCP7	370
OR2T11	USP17L15	C9J2P7	370
OR2T11	ZNF804B	A4D1E1	367
OR2T11	ZFP14	Q9HCL3	357
OR2T11	APCDD1L	Q8NCL9	356
OR2T11	E9PCK9	E9PCK9	325
OR2T11	ARK2C	Q6ZSG1	312
OR2T11	NYNRIN	Q9P2P1	306
OR2T11	RTL3	Q8N8U3	300
OR2T11	RPS6KC1	Q96S38	293
OR2T11	BEST3	Q8N1M1	290

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR2T11	H2BC9	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): HIST1H2BH (Proximity Label-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	60
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

175 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248627076:CTGT:C	donor_gain	0.7100
1:248627077:TGTT:T	donor_gain	0.7100
1:248626396:C:CT	donor_gain	0.6500
1:248626397:T:TT	donor_gain	0.6500
1:248627075:A:AC	donor_gain	0.6000
1:248627076:C:CC	donor_gain	0.6000
1:248626720:T:TA	donor_gain	0.5500
1:248626555:A:AC	donor_gain	0.5300
1:248626556:C:CC	donor_gain	0.5300
1:248626724:G:A	donor_gain	0.5300
1:248626601:A:AC	donor_gain	0.5200
1:248626602:C:CC	donor_gain	0.5200
1:248626772:G:C	donor_gain	0.5200
1:248626542:A:C	donor_gain	0.5100
1:248626551:T:TA	donor_gain	0.5100
1:248626320:A:AC	donor_gain	0.5000
1:248626321:C:CC	donor_gain	0.5000
1:248626557:A:C	donor_gain	0.5000
1:248626807:CAGA:C	donor_gain	0.5000
1:248626808:AGAA:A	donor_gain	0.5000
1:248627071:C:CA	donor_gain	0.5000
1:248626251:T:TA	donor_gain	0.4900
1:248627069:AGC:A	donor_gain	0.4900
1:248626597:T:TA	donor_gain	0.4800
1:248626622:T:TA	donor_gain	0.4800
1:248626438:G:GT	donor_gain	0.4700
1:248626780:AGG:A	donor_gain	0.4700
1:248626224:AATAC:A	donor_loss	0.4600
1:248626225:ATAC:A	donor_loss	0.4600
1:248626226:TACC:T	donor_loss	0.4600

AlphaMissense

2069 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248627102:G:C	F9L	0.831
1:248627102:G:T	F9L	0.831
1:248627104:A:G	F9L	0.831
1:248627033:G:C	F32L	0.774
1:248627033:G:T	F32L	0.774
1:248627035:A:G	F32L	0.774
1:248626607:A:C	F174L	0.764
1:248626607:A:T	F174L	0.764
1:248626609:A:G	F174L	0.764
1:248626391:G:C	S246R	0.763
1:248626391:G:T	S246R	0.763
1:248626393:T:G	S246R	0.763
1:248626604:G:C	F175L	0.756
1:248626604:G:T	F175L	0.756
1:248626606:A:G	F175L	0.756
1:248626893:A:C	L79R	0.745
1:248626893:A:G	L79P	0.727
1:248626385:G:C	F248L	0.707
1:248626385:G:T	F248L	0.707
1:248626387:A:G	F248L	0.707
1:248627054:A:C	F25L	0.696
1:248627054:A:T	F25L	0.696
1:248627056:A:G	F25L	0.696
1:248626832:G:C	F99L	0.690
1:248626832:G:T	F99L	0.690
1:248626834:A:G	F99L	0.690
1:248626802:G:C	F109L	0.684
1:248626802:G:T	F109L	0.684
1:248626804:A:G	F109L	0.684
1:248626307:G:C	F274L	0.665

dbSNP variants (sampled 300 via entrez): RS1001106546 (1:248631766 T>A), RS1001728119 (1:248633239 T>C), RS1003113350 (1:248627030 C>G), RS1004888092 (1:248625772 C>CA), RS1005670209 (1:248630176 GTGC>G), RS1006419833 (1:248627350 C>T), RS1007180907 (1:248630933 G>A), RS1007400113 (1:248628836 C>G,T), RS1007978156 (1:248623364 G>A), RS1008070127 (1:248635206 A>G), RS1008601005 (1:248634451 C>T), RS1009402802 (1:248623959 T>TG), RS1009837951 (1:248632468 G>A,C), RS1009935267 (1:248623456 C>T), RS1011866971 (1:248626023 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	2
CGP 52608	affects binding, increases reaction	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	affects methylation	1
Copper	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Cyclosporine	increases methylation	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.