OR2T2

Summary

OR2T2 (olfactory receptor family 2 subfamily T member 2, HGNC:14725) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T2 (Q6IF00). Odorant receptor. It is a selective cancer dependency (DepMap: 15.1% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 401992 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 71 total
• Cancer dependency (DepMap): dependent in 15.1% of screened cell lines
• MANE Select transcript: NM_001004136

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14725
Approved symbol	OR2T2
Name	olfactory receptor family 2 subfamily T member 2
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196240
Ensembl biotype	protein_coding
Entrez	401992

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641925, ENST00000642130

RefSeq mRNA: 1 — MANE Select: NM_001004136 NM_001004136

CCDS: CCDS31116

Canonical transcript exons

ENST00000610282 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 42.84.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0149 / max 9.4706, expressed in 5 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9652	0.0149	5

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	42.84	gold quality
colonic epithelium	UBERON:0000397	42.60	gold quality
ventricular zone	UBERON:0003053	40.59	silver quality
kidney	UBERON:0002113	40.56	gold quality
granulocyte	CL:0000094	40.30	gold quality
bone marrow cell	CL:0002092	40.20	gold quality
cortex of kidney	UBERON:0001225	38.44	gold quality
tonsil	UBERON:0002372	36.93	gold quality
metanephros cortex	UBERON:0010533	36.84	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
monocyte	CL:0000576	35.90	gold quality
leukocyte	CL:0000738	35.84	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.89	gold quality
lymph node	UBERON:0000029	34.78	gold quality
bone marrow	UBERON:0002371	33.81	gold quality
muscle tissue	UBERON:0002385	33.25	gold quality
vermiform appendix	UBERON:0001154	32.53	silver quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
placenta	UBERON:0001987	31.28	silver quality
blood	UBERON:0000178	31.03	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.49	gold quality
urinary bladder	UBERON:0001255	28.81	gold quality
duodenum	UBERON:0002114	28.14	gold quality
islet of Langerhans	UBERON:0000006	26.89	gold quality
uterine cervix	UBERON:0000002	26.87	gold quality
ectocervix	UBERON:0012249	26.67	gold quality
pancreas	UBERON:0001264	26.15	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 15.1% of screened cell lines.

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2t35	ENSMUSG00000091809
rattus_norvegicus	Or2t35	ENSRNOG00000084001

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T2 — Q6IF00 (reviewed: Q6IF00)

Alternative names: Olfactory receptor OR1-43

All UniProt accessions (1): Q6IF00

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004136* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IF00-F1	88.31	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 9

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

144 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T2	ZNF816	Q0VGE8	543
OR2T2	UBTFL1	P0CB47	445
OR2T2	HNRNPCL1	O60812	435
OR2T2	GTF3C6	Q969F1	400
OR2T2	LCN10	Q6JVE6	396
OR2T2	ZNF443	Q9Y2A4	371
OR2T2	VXN	Q8TAG6	371
OR2T2	ZNF595	Q8IYB9	365
OR2T2	KRTAP5-10	Q6L8G5	353
OR2T2	TAS2R46	P59540	348
OR2T2	TMEM204	Q9BSN7	324
OR2T2	ZNF717	Q9BY31	321
OR2T2	NBPF1	Q3BBV0	321
OR2T2	TMEM9	Q9P0T7	311
OR2T2	DDA1	Q9BW61	307

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR2T2	NME2P1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): NME2P1 (Affinity Capture-MS)

ESM2 similar proteins: A6NL26, O43749, O76001, O76002, O76100, O95006, P0C7T2, P0DMU2, P23272, P23274, P30955, P58173, P59922, P70526, Q13607, Q60890, Q6IEU7, Q6IEZ7, Q6IF00, Q6IF36, Q6UXT6, Q8NGE5, Q8NGI7, Q8NGL2, Q8NGN7, Q8NGP8, Q8NGQ2, Q8NGS0, Q8NGS2, Q8NGX2, Q8NGX3, Q8NGZ4, Q8NGZ5, Q8NH01, Q8NH02, Q8NH04, Q8NH80, Q8NHA6, Q8VEY3, Q8VG44

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

71 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	59
Likely benign	10
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

246 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248453166:C:G	donor_gain	0.9800
1:248453235:G:GA	donor_gain	0.9700
1:248453234:T:TA	donor_gain	0.9500
1:248453216:GG:G	donor_gain	0.9200
1:248453217:GGTT:G	donor_gain	0.9200
1:248453065:G:GT	donor_gain	0.8900
1:248453215:AG:A	donor_gain	0.8200
1:248453456:C:G	acceptor_gain	0.8200
1:248453220:T:A	donor_gain	0.8000
1:248453126:G:GT	donor_gain	0.7900
1:248453222:GCT:G	donor_gain	0.7700
1:248453155:GCC:G	donor_gain	0.7500
1:248453396:T:G	donor_gain	0.7500
1:248453216:G:GA	donor_gain	0.7200
1:248453455:AC:A	acceptor_gain	0.7200
1:248453092:GC:G	donor_gain	0.6900
1:248453173:GC:G	donor_gain	0.6900
1:248453454:C:G	acceptor_gain	0.6600
1:248453460:C:G	acceptor_gain	0.6400
1:248453096:T:G	donor_gain	0.6300
1:248453131:G:GT	donor_gain	0.6100
1:248453236:G:GG	donor_gain	0.6100
1:248453308:A:AG	acceptor_gain	0.6100
1:248453309:G:GG	acceptor_gain	0.6100
1:248453394:G:GT	donor_gain	0.6100
1:248453050:G:GT	donor_gain	0.5900
1:248453165:GC:G	donor_gain	0.5700
1:248453131:G:T	donor_gain	0.5600
1:248453166:C:CG	donor_gain	0.5600
1:248453254:G:GA	donor_gain	0.5600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000030325 (1:248450665 A>G), RS1001429865 (1:248455389 T>C), RS1001824218 (1:248446218 C>T), RS1005788593 (1:248447284 C>T), RS1007579141 (1:248444992 GA>G), RS1007677419 (1:248444306 G>T), RS1008435402 (1:248446950 A>G), RS1008578513 (1:248450509 G>A), RS1008673390 (1:248449488 G>A), RS1010178192 (1:248451676 C>G,T), RS1014440227 (1:248446178 T>C), RS1014801050 (1:248447126 G>C,T), RS1014942785 (1:248445346 C>T), RS1015865016 (1:248447352 G>T), RS1017381984 (1:248449544 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.