OR2T29

Summary

OR2T29 (olfactory receptor family 2 subfamily T member 29, HGNC:31253) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T29 (Q8NH02). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 343563 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 10 total
• MANE Select transcript: NM_001004694

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31253
Approved symbol	OR2T29
Name	olfactory receptor family 2 subfamily T member 29
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000182783
Ensembl biotype	protein_coding
Entrez	343563

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000328570, ENST00000641069

RefSeq mRNA: 1 — MANE Select: NM_001004694 NM_001004694

CCDS: CCDS55695

Canonical transcript exons

ENST00000641069 — 2 exons

Exon	Start	End
ENSE00003812881	248562726	248562772
ENSE00003813973	248556912	248559501

Expression profiles

Bgee: expression breadth broad, 16 present calls, max score 81.53.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.53	gold quality
granulocyte	CL:0000094	39.02	gold quality
sural nerve	UBERON:0015488	38.47	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
vermiform appendix	UBERON:0001154	36.90	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
adult mammalian kidney	UBERON:0000082	36.45	gold quality
lymph node	UBERON:0000029	36.36	silver quality
bone marrow cell	CL:0002092	36.16	gold quality
tonsil	UBERON:0002372	36.04	silver quality
kidney	UBERON:0002113	35.58	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
primary visual cortex	UBERON:0002436	33.70	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
cortex of kidney	UBERON:0001225	31.01	gold quality
right uterine tube	UBERON:0001302	30.59	gold quality
metanephros cortex	UBERON:0010533	30.56	gold quality
prefrontal cortex	UBERON:0000451	30.55	gold quality
superior frontal gyrus	UBERON:0002661	30.47	gold quality
leukocyte	CL:0000738	30.00	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.53	gold quality
saliva-secreting gland	UBERON:0001044	29.04	gold quality
minor salivary gland	UBERON:0001830	29.03	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2t48	ENSMUSG00000050818
mus_musculus	Or2t47	ENSMUSG00000057654
mus_musculus	Or2t49	ENSMUSG00000058807
mus_musculus	Or2t43	ENSMUSG00000059279
mus_musculus	Or2t46	ENSMUSG00000060765
mus_musculus	Or2t29	ENSMUSG00000064252
rattus_norvegicus	Or2t48	ENSRNOG00000068864
rattus_norvegicus	Or2t47	ENSRNOG00000072569
rattus_norvegicus		ENSRNOG00000074273
rattus_norvegicus	Or2t47e	ENSRNOG00000076869
rattus_norvegicus	Or2t48d	ENSRNOG00000079170
rattus_norvegicus	Or2t47d	ENSRNOG00000079612
rattus_norvegicus		ENSRNOG00000081472
rattus_norvegicus	Olr1428	ENSRNOG00000083977

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2T29 — Q8NH02 (reviewed: Q8NH02)

All UniProt accessions (1): Q8NH02

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004694* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH02-F1	89.66	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 101–193

Glycosylation sites (2): 3, 9

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, PULVER_FOREY_PERTURB_ATTRITION_G1_S

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

176 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T29	A0A087WY73	A0A087WY73	601
OR2T29	CCER1	Q8TC90	505
OR2T29	TBC1D26	Q86UD7	480
OR2T29	F2Z2I4	F2Z2I4	474
OR2T29	DEFB130A	P0DP74	472
OR2T29	GFY	I3L273	399
OR2T29	DEFB118	Q96PH6	397
OR2T29	SMR3B	P02814	393
OR2T29	ANKRD36C	Q5JPF3	377
OR2T29	FRMD1	Q8N878	371
OR2T29	CCDC181	Q5TID7	370
OR2T29	MRPS26	Q9BYN8	366
OR2T29	TAS2R43	P59537	357
OR2T29	A0A140T9Z0	A0A140T9Z0	354
OR2T29	GPR146	Q96CH1	348

IntAct

0 interactions, top by confidence:

BioGRID (1): OR2T29 (Affinity Capture-MS)

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

10 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	8
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

202 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248559220:A:AC	donor_gain	0.8600
1:248559219:CATG:C	donor_gain	0.8200
1:248559217:CCCA:C	donor_gain	0.7900
1:248559222:G:T	donor_gain	0.7800
1:248559221:TG:T	donor_gain	0.7700
1:248558941:T:TA	donor_gain	0.7600
1:248559304:A:C	donor_gain	0.7600
1:248558884:A:C	donor_gain	0.7200
1:248558879:G:C	donor_gain	0.6900
1:248558963:C:CA	donor_gain	0.6600
1:248559299:A:AC	donor_gain	0.6400
1:248559204:G:GT	donor_gain	0.6200
1:248559060:G:T	donor_gain	0.6100
1:248558896:T:C	donor_gain	0.6000
1:248558882:A:AC	donor_gain	0.5700
1:248558883:C:CC	donor_gain	0.5700
1:248559114:G:C	donor_gain	0.5400
1:248559218:CCAT:C	donor_gain	0.5300
1:248559392:C:CT	donor_gain	0.5300
1:248558722:CCA:C	acceptor_gain	0.5200
1:248559448:T:TA	donor_gain	0.5200
1:248559451:A:AT	donor_gain	0.5200
1:248558800:C:CC	acceptor_gain	0.5100
1:248558807:CGG:C	acceptor_gain	0.5100
1:248558895:A:AC	donor_gain	0.5100
1:248559063:CCTA:C	donor_gain	0.5000
1:248558723:CA:C	acceptor_gain	0.4900
1:248558930:CAG:C	donor_gain	0.4900
1:248559456:T:TA	donor_gain	0.4800
1:248558808:G:T	acceptor_gain	0.4700

AlphaMissense

2080 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248558727:G:C	F255L	0.914
1:248558727:G:T	F255L	0.914
1:248558729:A:G	F255L	0.914
1:248558949:G:C	F181L	0.870
1:248558949:G:T	F181L	0.870
1:248558951:A:G	F181L	0.870
1:248559444:G:C	F16L	0.855
1:248559444:G:T	F16L	0.855
1:248559446:A:G	F16L	0.855
1:248558946:G:C	F182L	0.847
1:248558946:G:T	F182L	0.847
1:248558948:A:G	F182L	0.847
1:248559126:C:A	M122I	0.823
1:248559126:C:G	M122I	0.823
1:248559126:C:T	M122I	0.823
1:248558607:A:C	S295R	0.820
1:248558607:A:T	S295R	0.820
1:248558609:T:G	S295R	0.820
1:248558976:G:C	F172L	0.819
1:248558976:G:T	F172L	0.819
1:248558978:A:G	F172L	0.819
1:248559375:G:C	F39L	0.810
1:248559375:G:T	F39L	0.810
1:248559377:A:G	F39L	0.810
1:248559174:G:C	F106L	0.801
1:248559174:G:T	F106L	0.801
1:248559176:A:G	F106L	0.801
1:248558622:G:C	N290K	0.789
1:248558622:G:T	N290K	0.789
1:248559144:A:C	F116L	0.768

dbSNP variants (sampled 300 via entrez): RS1000077732 (1:248564654 C>A), RS1000186768 (1:248564236 T>A), RS1000525863 (1:248557705 C>T), RS1001837388 (1:248562972 C>T), RS1001868488 (1:248562523 C>A,T), RS1003286115 (1:248483329 G>C), RS1007729904 (1:248560086 G>A,C), RS1007744582 (1:248557530 C>G), RS1008732094 (1:248564638 G>A), RS1008766488 (1:248563802 T>C), RS1008796258 (1:248563179 C>T), RS1010268065 (1:248564674 T>A,C), RS1010510076 (1:248483311 G>A), RS1013700773 (1:248560616 T>C), RS1015953544 (1:248563019 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
hydroxyhydroquinone	increases expression	1
CGP 52608	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.