OR2T3

Summary

OR2T3 (olfactory receptor family 2 subfamily T member 3, HGNC:14727) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T3 (Q8NH03). Odorant receptor. It is a selective cancer dependency (DepMap: 60.0% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 343173 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 74 total
• Cancer dependency (DepMap): dependent in 60.0% of screened cell lines
• MANE Select transcript: NM_001005495

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14727
Approved symbol	OR2T3
Name	olfactory receptor family 2 subfamily T member 3
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000196539
Ensembl biotype	protein_coding
Entrez	343173

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000359594

RefSeq mRNA: 1 — MANE Select: NM_001005495 NM_001005495

CCDS: CCDS31117

Canonical transcript exons

ENST00000359594 — 1 exons

Exon	Start	End
ENSE00001691264	248473351	248474307

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 37.20.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
vermiform appendix	UBERON:0001154	31.29	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
lymph node	UBERON:0000029	29.83	gold quality
urinary bladder	UBERON:0001255	29.32	gold quality
prefrontal cortex	UBERON:0000451	29.23	gold quality
liver	UBERON:0002107	29.14	gold quality
monocyte	CL:0000576	28.21	gold quality
leukocyte	CL:0000738	28.15	gold quality
duodenum	UBERON:0002114	28.14	gold quality
cortex of kidney	UBERON:0001225	28.02	gold quality
placenta	UBERON:0001987	27.36	gold quality
adult mammalian kidney	UBERON:0000082	26.63	silver quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
saliva-secreting gland	UBERON:0001044	26.47	gold quality
minor salivary gland	UBERON:0001830	26.20	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
adrenal tissue	UBERON:0018303	25.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
muscle of leg	UBERON:0001383	25.01	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 60.0% of screened cell lines.

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T3 — Q8NH03 (reviewed: Q8NH03)

All UniProt accessions (2): A0A126GVW5, Q8NH03

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005495* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH03-F1	88.34	0.59

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 102–194

Glycosylation sites (2): 5, 10

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

88 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T3	CACNG1	Q06432	351
OR2T3	CYP2F1	P24903	325
OR2T3	EPPK1	P58107	305
OR2T3	HLA-DRB5	Q30154	300
OR2T3	HS6ST1	O60243	249
OR2T3	TAS2R60	P59551	247
OR2T3	ACTRT2	Q8TDY3	228
OR2T3	SPINK5	Q9NQ38	223
OR2T3	CDH4	P55283	204
OR2T3	CUBN	O60494	202
OR2T3	ESAM	Q96AP7	199
OR2T3	KLHL25	Q9H0H3	199
OR2T3	EHMT1	Q9H9B1	185
OR2T3	RTP1	P59025	176
OR2T3	BNIPL	Q7Z465	175

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	73
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

142 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248473782:G:GT	donor_gain	0.9800
1:248473800:GTC:G	donor_gain	0.9200
1:248473779:GAGG:G	donor_gain	0.8900
1:248473694:C:G	donor_gain	0.8500
1:248473731:A:G	donor_gain	0.8100
1:248473781:GG:G	donor_gain	0.7500
1:248473961:T:G	donor_gain	0.7400
1:248473785:GTGCC:G	donor_gain	0.7200
1:248473786:T:A	donor_gain	0.6900
1:248473809:C:G	donor_gain	0.6700
1:248473580:T:G	donor_gain	0.6600
1:248473802:C:A	donor_gain	0.6400
1:248474044:AGGAT:A	acceptor_gain	0.6400
1:248474045:GGATG:G	acceptor_gain	0.6400
1:248473778:AGAG:A	donor_gain	0.6300
1:248474045:GGA:G	acceptor_gain	0.6000
1:248474044:AG:A	acceptor_gain	0.5900
1:248474045:GG:G	acceptor_gain	0.5900
1:248474040:CCACA:C	acceptor_loss	0.5800
1:248474041:CACA:C	acceptor_loss	0.5800
1:248474043:CA:C	acceptor_loss	0.5800
1:248473595:C:G	donor_gain	0.5700
1:248473700:T:TA	donor_gain	0.5600
1:248474045:GGAT:G	acceptor_gain	0.5600
1:248473781:G:GA	donor_gain	0.5500
1:248473796:T:A	donor_gain	0.5500
1:248473949:A:AG	donor_gain	0.5500
1:248474044:A:AG	acceptor_gain	0.5500
1:248474045:G:GG	acceptor_gain	0.5500
1:248473541:T:G	donor_gain	0.5300

AlphaMissense

2096 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248473399:T:C	F17L	0.915
1:248473401:C:A	F17L	0.915
1:248473401:C:G	F17L	0.915
1:248473894:T:C	F182L	0.905
1:248473896:T:A	F182L	0.905
1:248473896:T:G	F182L	0.905
1:248474236:A:C	S296R	0.883
1:248474238:T:A	S296R	0.883
1:248474238:T:G	S296R	0.883
1:248473400:T:G	F17C	0.875
1:248473867:T:C	F173L	0.867
1:248473869:T:A	F173L	0.867
1:248473869:T:G	F173L	0.867
1:248473897:T:C	F183L	0.851
1:248473899:C:A	F183L	0.851
1:248473899:C:G	F183L	0.851
1:248473400:T:C	F17S	0.848
1:248473417:T:C	F23L	0.826
1:248473419:T:A	F23L	0.826
1:248473419:T:G	F23L	0.826
1:248473468:T:C	F40L	0.824
1:248473470:C:A	F40L	0.824
1:248473470:C:G	F40L	0.824
1:248474119:T:C	F257L	0.818
1:248474121:C:A	F257L	0.818
1:248474121:C:G	F257L	0.818
1:248473730:G:C	R127P	0.813
1:248473719:G:A	M123I	0.810
1:248473719:G:C	M123I	0.810
1:248473719:G:T	M123I	0.810

dbSNP variants (sampled 300 via entrez): RS1002757620 (1:248472864 A>G), RS1004602883 (1:248471357 A>G), RS1004995456 (1:248471552 A>G), RS1010202571 (1:248471563 G>A,T), RS1011340404 (1:248472782 T>C,G), RS1011862236 (1:248472318 G>A), RS1015710005 (1:248473534 A>C), RS1018630751 (1:248471625 A>C,T), RS1018685126 (1:248471358 T>C), RS1020189558 (1:248472333 C>T), RS1020516238 (1:248472789 G>A), RS1027057371 (1:248472997 G>A), RS1028758417 (1:248471677 A>G), RS1035642304 (1:248472939 T>A), RS1039987916 (1:248472131 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression	1
Phthalic Acids	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.