OR2T34

Summary

OR2T34 (olfactory receptor family 2 subfamily T member 34, HGNC:31256) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T34 (Q8NGX1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127068 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 67 total
• MANE Select transcript: NM_001001821

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31256
Approved symbol	OR2T34
Name	olfactory receptor family 2 subfamily T member 34
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000183310
Ensembl biotype	protein_coding
Entrez	127068

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000328782

RefSeq mRNA: 1 — MANE Select: NM_001001821 NM_001001821

CCDS: CCDS31120

Canonical transcript exons

ENST00000328782 — 1 exons

Exon	Start	End
ENSE00001619909	248573801	248574757

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 38.40.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.40	gold quality
granulocyte	CL:0000094	37.73	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.97	gold quality
bone marrow	UBERON:0002371	32.88	gold quality
muscle tissue	UBERON:0002385	32.23	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
lymph node	UBERON:0000029	30.31	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.35	gold quality
blood	UBERON:0000178	28.97	gold quality
duodenum	UBERON:0002114	28.14	gold quality
placenta	UBERON:0001987	27.48	gold quality
monocyte	CL:0000576	27.44	gold quality
adult mammalian kidney	UBERON:0000082	26.58	silver quality
urinary bladder	UBERON:0001255	26.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
cortex of kidney	UBERON:0001225	25.84	gold quality
calcaneal tendon	UBERON:0003701	25.00	gold quality
muscle of leg	UBERON:0001383	24.92	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.27	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2T34 — Q8NGX1 (reviewed: Q8NGX1)

Alternative names: Olfactory receptor OR1-63

All UniProt accessions (1): Q8NGX1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001821* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGX1-F1	87.85	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 102–194

Glycosylation sites (2): 5, 10

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, CAMPS_COLON_CANCER_COPY_NUMBER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_DOWN_BY_2ND_EGF_PULSE, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

152 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T34	ACTRT2	Q8TDY3	542
OR2T34	B9ZVM9	B9ZVM9	510
OR2T34	NUTM2F	A1L443	507
OR2T34	KLHL25	Q9H0H3	480
OR2T34	SIMC1	Q8NDZ2	418
OR2T34	WDFY4	Q6ZS81	398
OR2T34	ANO2	Q9NQ90	366
OR2T34	GNG7	O60262	360
OR2T34	LCE1C	Q5T751	350
OR2T34	PDE2A	O00408	338
OR2T34	LRRN2	O75325	313
OR2T34	BNIPL	Q7Z465	310
OR2T34	SPHKAP	Q2M3C7	307
OR2T34	CACNG1	Q06432	300
OR2T34	CAMK2D	Q13557	290

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2R8YED5, A6NM03, O14581, O60412, O76099, O95006, O95047, O95371, P34982, P34984, P47884, P58170, Q15619, Q15622, Q5TZ20, Q60883, Q60887, Q60891, Q6IFH4, Q7Z3T1, Q8N628, Q8NG84, Q8NG95, Q8NG98, Q8NG99, Q8NGA0, Q8NGA1, Q8NGA2, Q8NGQ5, Q8NGR9, Q8NGS1, Q8NGS2, Q8NGS3, Q8NGV0, Q8NGW1, Q8NGX1, Q8NH06, Q8NH80, Q8NHA4, Q95157

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

135 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248574325:C:CA	donor_gain	0.9800
1:248574305:TGA:T	donor_gain	0.9200
1:248574325:CCCT:C	donor_gain	0.8800
1:248574414:G:C	donor_gain	0.8400
1:248574377:T:C	donor_gain	0.8200
1:248574147:G:C	donor_gain	0.7600
1:248574528:A:C	donor_gain	0.7500
1:248574318:TGGCA:T	donor_gain	0.7300
1:248574324:AC:A	donor_gain	0.7300
1:248574322:A:T	donor_gain	0.6900
1:248574299:G:C	donor_gain	0.6700
1:248574306:G:T	donor_gain	0.6500
1:248574323:C:T	donor_gain	0.6500
1:248574140:CAG:C	donor_gain	0.6400
1:248574058:TCATC:T	acceptor_gain	0.6300
1:248574059:CATCC:C	acceptor_gain	0.6300
1:248574142:G:C	donor_gain	0.6300
1:248574326:CCTC:C	donor_gain	0.6300
1:248574158:A:AC	donor_gain	0.6100
1:248574513:G:C	donor_gain	0.6000
1:248574060:ATC:A	acceptor_gain	0.5900
1:248574062:CCTG:C	acceptor_loss	0.5900
1:248574063:C:G	acceptor_loss	0.5900
1:248574064:T:A	acceptor_loss	0.5900
1:248574523:G:C	donor_gain	0.5900
1:248574061:TC:T	acceptor_gain	0.5800
1:248574062:CC:C	acceptor_gain	0.5800
1:248574567:A:C	donor_gain	0.5600
1:248574059:CATC:C	acceptor_gain	0.5500
1:248574322:ACAC:A	donor_gain	0.5500

AlphaMissense

2095 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248574707:G:C	F17L	0.897
1:248574707:G:T	F17L	0.897
1:248574709:A:G	F17L	0.897
1:248573870:A:C	S296R	0.871
1:248573870:A:T	S296R	0.871
1:248573872:T:G	S296R	0.871
1:248574212:A:C	F182L	0.847
1:248574212:A:T	F182L	0.847
1:248574214:A:G	F182L	0.847
1:248574239:A:C	F173L	0.831
1:248574239:A:T	F173L	0.831
1:248574241:A:G	F173L	0.831
1:248574689:A:C	F23L	0.792
1:248574689:A:T	F23L	0.792
1:248574691:A:G	F23L	0.792
1:248574638:G:C	F40L	0.781
1:248574638:G:T	F40L	0.781
1:248574640:A:G	F40L	0.781
1:248574209:G:C	F183L	0.754
1:248574209:G:T	F183L	0.754
1:248574211:A:G	F183L	0.754
1:248574437:G:C	F107L	0.748
1:248574437:G:T	F107L	0.748
1:248574439:A:G	F107L	0.748
1:248574378:C:G	R127P	0.740
1:248574708:A:C	F17C	0.734
1:248573987:G:C	F257L	0.710
1:248573987:G:T	F257L	0.710
1:248573989:A:G	F257L	0.710
1:248574298:A:G	W154R	0.710

dbSNP variants (sampled 300 via entrez): RS1006991715 (1:248576481 T>A), RS1012308781 (1:248574599 G>A), RS1018469871 (1:248574821 A>G), RS1024305103 (1:248573472 CAAT>C), RS1029294765 (1:248574694 G>T), RS1030767594 (1:248576678 T>C), RS1036496101 (1:248575871 CAGTTTT>C), RS1044055618 (1:248574220 G>A), RS1045133860 (1:248575421 G>T), RS1045569675 (1:248574608 G>T), RS1056425110 (1:248574563 G>A,T), RS111639661 (1:248575309 G>A), RS111688645 (1:248576085 C>A,T), RS113818137 (1:248575510 T>A), RS113921150 (1:248576170 CAA>C,CA,CAAA,CAAAA,CAAAAA,CAAAAAAAAAAAAAAAAAAAA,CAAAAAAAAAAAAAAAAAAAAAAAAA)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Cadmium	decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.