OR2T4

Summary

OR2T4 (olfactory receptor family 2 subfamily T member 4, HGNC:15016) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T4 (Q8NH00). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 127074 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 50 total
• MANE Select transcript: NM_001004696

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15016
Approved symbol	OR2T4
Name	olfactory receptor family 2 subfamily T member 4
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	OR2T4Q
Ensembl gene	ENSG00000196944
Ensembl biotype	protein_coding
Entrez	127074

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000366473

RefSeq mRNA: 1 — MANE Select: NM_001004696 NM_001004696

CCDS: CCDS31113

Canonical transcript exons

ENST00000366473 — 1 exons

Exon	Start	End
ENSE00002410076	248361665	248362627

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 40.56.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	40.56	silver quality
lower esophagus mucosa	UBERON:0035834	39.36	gold quality
ganglionic eminence	UBERON:0004023	37.50	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
prefrontal cortex	UBERON:0000451	36.99	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
skeletal muscle tissue	UBERON:0001134	34.93	gold quality
muscle tissue	UBERON:0002385	32.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
frontal cortex	UBERON:0001870	31.98	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	31.18	silver quality
sural nerve	UBERON:0015488	30.93	gold quality
right uterine tube	UBERON:0001302	30.78	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
cerebral cortex	UBERON:0000956	29.77	gold quality
primary visual cortex	UBERON:0002436	29.37	silver quality
liver	UBERON:0002107	28.92	gold quality
monocyte	CL:0000576	28.18	gold quality
duodenum	UBERON:0002114	28.14	gold quality
leukocyte	CL:0000738	28.13	gold quality
urinary bladder	UBERON:0001255	27.94	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.22	gold quality
tonsil	UBERON:0002372	27.05	gold quality
substantia nigra	UBERON:0002038	27.00	silver quality
blood	UBERON:0000178	26.86	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2t48	ENSMUSG00000050818
mus_musculus	Or2t47	ENSMUSG00000057654
mus_musculus	Or2t49	ENSMUSG00000058807
mus_musculus	Or2t43	ENSMUSG00000059279
mus_musculus	Or2t46	ENSMUSG00000060765
mus_musculus	Or2t29	ENSMUSG00000064252
rattus_norvegicus	Or2t48	ENSRNOG00000068864
rattus_norvegicus	Or2t47	ENSRNOG00000072569
rattus_norvegicus		ENSRNOG00000074273
rattus_norvegicus	Or2t47e	ENSRNOG00000076869
rattus_norvegicus	Or2t48d	ENSRNOG00000079170
rattus_norvegicus	Or2t47d	ENSRNOG00000079612
rattus_norvegicus		ENSRNOG00000081472
rattus_norvegicus	Olr1428	ENSRNOG00000083977

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T4 — Q8NH00 (reviewed: Q8NH00)

Alternative names: Olfactory receptor OR1-60

All UniProt accessions (1): A0A2C9F2M9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004696* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 3, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH00-F1	83.85	0.61

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 129–221

Glycosylation sites (3): 31, 37, 218

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, SRSF9_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

188 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T4	C1orf94	Q6P1W5	580
OR2T4	ZNF850	A8MQ14	475
OR2T4	FAM47C	Q5HY64	450
OR2T4	NHSL2	Q5HYW2	419
OR2T4	FAM186A	A6NE01	418
OR2T4	TMEM106C	Q9BVX2	398
OR2T4	KLHL23	Q8NBE8	377
OR2T4	ANKRD36C	Q5JPF3	370
OR2T4	KNDC1	Q76NI1	360
OR2T4	EML6	Q6ZMW3	349
OR2T4	TAS2R43	P59537	348
OR2T4	RFLNA	Q6ZTI6	337
OR2T4	MROH2B	Q7Z745	323
OR2T4	CNKSR3	Q6P9H4	320
OR2T4	SLC10A7	Q0GE19	311

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A3KFT3, O76100, O95222, P23269, P23272, P23274, P30955, P34986, P37071, P70526, Q15622, Q6IEZ7, Q6IF00, Q6IF42, Q8N146, Q8NG81, Q8NG83, Q8NGC7, Q8NGC8, Q8NGE0, Q8NGE7, Q8NGG7, Q8NGI9, Q8NGL3, Q8NGP8, Q8NGQ2, Q8NGQ6, Q8NGS0, Q8NGS2, Q8NGS3, Q8NGS4, Q8NGX2, Q8NGZ0, Q8NGZ9, Q8NH00, Q8NH01, Q8NH02, Q8NH04, Q8NH74, Q8NH80

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

50 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

244 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248362421:A:AG	donor_gain	0.6900
1:248362417:G:GA	donor_gain	0.6800
1:248362313:A:AG	donor_gain	0.6300
1:248362183:T:TA	acceptor_gain	0.6100
1:248362416:T:TA	donor_gain	0.6100
1:248362214:GA:G	donor_gain	0.5900
1:248362215:AA:A	donor_gain	0.5900
1:248362431:ATG:A	acceptor_gain	0.5900
1:248362309:G:GA	donor_gain	0.5800
1:248362213:TG:T	donor_gain	0.5700
1:248362354:C:CA	acceptor_gain	0.5700
1:248362419:TC:T	donor_gain	0.5700
1:248362431:AT:A	acceptor_gain	0.5700
1:248362214:G:GT	donor_gain	0.5600
1:248362492:GATG:G	donor_gain	0.5500
1:248362483:G:GT	donor_gain	0.5400
1:248362491:TGATG:T	donor_loss	0.5400
1:248362493:ATG:A	donor_loss	0.5400
1:248362494:TGGT:T	donor_loss	0.5400
1:248362495:GGT:G	donor_loss	0.5400
1:248362496:G:GA	donor_loss	0.5400
1:248362497:T:G	donor_loss	0.5400
1:248362487:G:GT	donor_gain	0.5200
1:248362272:T:G	donor_gain	0.5100
1:248361763:G:GA	donor_gain	0.5000
1:248362378:G:GT	donor_gain	0.5000
1:248362385:GCC:G	donor_gain	0.5000
1:248362420:C:A	donor_gain	0.5000
1:248361704:T:TA	donor_gain	0.4900
1:248362432:T:TA	acceptor_gain	0.4900

AlphaMissense

2112 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:248362547:A:C	S323R	0.927
1:248362549:T:A	S323R	0.927
1:248362549:T:G	S323R	0.927
1:248362041:G:C	R154P	0.924
1:248361710:T:C	F44L	0.877
1:248361712:C:A	F44L	0.877
1:248361712:C:G	F44L	0.877
1:248362427:T:C	F283L	0.877
1:248362429:C:A	F283L	0.877
1:248362429:C:G	F283L	0.877
1:248361873:T:C	L98S	0.863
1:248362534:C:A	N318K	0.860
1:248362534:C:G	N318K	0.860
1:248362118:T:C	C180R	0.859
1:248362121:T:A	W181R	0.857
1:248362121:T:C	W181R	0.857
1:248362030:G:A	M150I	0.848
1:248362030:G:C	M150I	0.848
1:248362030:G:T	M150I	0.848
1:248362205:T:C	F209L	0.839
1:248362207:C:A	F209L	0.839
1:248362207:C:G	F209L	0.839
1:248361802:T:A	N74K	0.833
1:248361802:T:G	N74K	0.833
1:248362338:T:C	I253T	0.833
1:248362555:G:C	R325S	0.832
1:248362555:G:T	R325S	0.832
1:248362039:C:A	D153E	0.827
1:248362039:C:G	D153E	0.827
1:248362410:T:C	L277P	0.827

dbSNP variants (sampled 300 via entrez): RS1000480574 (1:248359978 C>G), RS1001434985 (1:248362002 G>A,T), RS1005818378 (1:248361291 A>C,G), RS1006157036 (1:248359815 C>A), RS1007002629 (1:248360068 G>A,C), RS1007661549 (1:248359867 C>A), RS1008476744 (1:248362412 A>C,G), RS1008721144 (1:248361364 G>T), RS1009065879 (1:248361531 C>G,T), RS1009791159 (1:248361243 G>A), RS1010257412 (1:248361509 C>A,T), RS1012374916 (1:248359693 A>G), RS1013043085 (1:248363020 T>C), RS1014891949 (1:248362757 C>A,T), RS1015587715 (1:248362481 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (1): breast ductal adenocarcinoma (MONDO:0005590)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Endosulfan	increases expression, decreases reaction, decreases expression	2
hydroxyhydroquinone	increases expression	1
sulforaphane	decreases expression	1
Hydrogen Peroxide	decreases expression	1
Tetrachlorodibenzodioxin	decreases reaction, increases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	PHASE2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	PHASE1/PHASE2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855	PHASE1/PHASE2	COMPLETED	Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908	EARLY_PHASE1	COMPLETED	Broccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041	EARLY_PHASE1	COMPLETED	Intraoperative Imaging of Breast Cancer With Indocyanine Green
NCT01208974	Not specified	ACTIVE_NOT_RECRUITING	Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198	Not specified	TERMINATED	Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397	Not specified	UNKNOWN	MRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532	Not specified	COMPLETED	Living Well After Breast Surgery