OR2T5

Summary

OR2T5 (olfactory receptor family 2 subfamily T member 5, HGNC:15017) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T5 (Q6IEZ7). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 401993 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 25 total
• MANE Select transcript: NM_001004697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15017
Approved symbol	OR2T5
Name	olfactory receptor family 2 subfamily T member 5
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000203661
Ensembl biotype	protein_coding
Entrez	401993

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641363

RefSeq mRNA: 1 — MANE Select: NM_001004697 NM_001004697

CCDS: CCDS31118

Canonical transcript exons

ENST00000611272 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 37.20.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
sural nerve	UBERON:0015488	36.03	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.45	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
kidney	UBERON:0002113	32.40	silver quality
cortex of kidney	UBERON:0001225	32.37	silver quality
bone marrow	UBERON:0002371	31.74	gold quality
placenta	UBERON:0001987	31.06	silver quality
muscle tissue	UBERON:0002385	31.06	gold quality
metanephros cortex	UBERON:0010533	30.95	gold quality
prefrontal cortex	UBERON:0000451	30.32	gold quality
lymph node	UBERON:0000029	30.29	gold quality
primary visual cortex	UBERON:0002436	30.17	gold quality
monocyte	CL:0000576	30.07	gold quality
adult mammalian kidney	UBERON:0000082	29.99	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
leukocyte	CL:0000738	29.84	gold quality
vermiform appendix	UBERON:0001154	29.37	gold quality
liver	UBERON:0002107	28.75	gold quality
duodenum	UBERON:0002114	28.14	gold quality
superior frontal gyrus	UBERON:0002661	27.20	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
blood	UBERON:0000178	26.75	gold quality
frontal cortex	UBERON:0001870	26.30	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

14 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2t48	ENSMUSG00000050818
mus_musculus	Or2t47	ENSMUSG00000057654
mus_musculus	Or2t49	ENSMUSG00000058807
mus_musculus	Or2t43	ENSMUSG00000059279
mus_musculus	Or2t46	ENSMUSG00000060765
mus_musculus	Or2t29	ENSMUSG00000064252
rattus_norvegicus	Or2t48	ENSRNOG00000068864
rattus_norvegicus	Or2t47	ENSRNOG00000072569
rattus_norvegicus		ENSRNOG00000074273
rattus_norvegicus	Or2t47e	ENSRNOG00000076869
rattus_norvegicus	Or2t48d	ENSRNOG00000079170
rattus_norvegicus	Or2t47d	ENSRNOG00000079612
rattus_norvegicus		ENSRNOG00000081472
rattus_norvegicus	Olr1428	ENSRNOG00000083977

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T5 — Q6IEZ7 (reviewed: Q6IEZ7)

Alternative names: Olfactory receptor OR1-62

All UniProt accessions (1): Q6IEZ7

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004697* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IEZ7-F1	89.69	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 101–193

Glycosylation sites (2): 3, 9

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, PULVER_FOREY_PERTURB_ACCUMULATION_G1_S, PULVER_FOREY_PERTURB_ATTRITION_M_EG1

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

94 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T5	RIBC1	Q8N443	545
OR2T5	TERB2	Q8NHR7	480
OR2T5	CABP2	Q9NPB3	447
OR2T5	LTAP1	Q9BWL3	447
OR2T5	DDX19A	Q9NUU7	439
OR2T5	SGSM2	O43147	434
OR2T5	KRR1	Q13601	418
OR2T5	PCDHA13	Q9Y5I0	412
OR2T5	NAALADL2	Q58DX5	400
OR2T5	CYP2F1	P24903	392
OR2T5	STYK1	Q6J9G0	372
OR2T5	GLIS1	Q8NBF1	349
OR2T5	GLIPR1	P48060	348
OR2T5	GSTZ1	O43708	338
OR2T5	GLIPR1L2	Q4G1C9	336

IntAct

0 interactions, top by confidence:

BioGRID (1): OR2T5 (Affinity Capture-MS)

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

25 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

189 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248488859:A:AG	donor_gain	0.8600
1:248488856:GTCA:G	donor_gain	0.8100
1:248488857:TCAT:T	donor_gain	0.8100
1:248488776:T:G	donor_gain	0.8000
1:248488858:C:A	donor_gain	0.7700
1:248489196:T:G	donor_gain	0.7000
1:248488780:C:CG	donor_gain	0.6800
1:248489116:G:GT	donor_gain	0.6700
1:248489201:C:G	donor_gain	0.6700
1:248488624:A:T	donor_gain	0.6600
1:248488687:G:GA	donor_gain	0.6200
1:248488875:T:TA	donor_gain	0.6200
1:248489020:C:A	donor_gain	0.6100
1:248489184:A:G	donor_gain	0.5900
1:248489197:G:GG	donor_gain	0.5700
1:248488966:C:G	donor_gain	0.5400
1:248489270:ACC:A	acceptor_gain	0.5200
1:248489279:A:AG	acceptor_gain	0.5200
1:248489280:G:GG	acceptor_gain	0.5200
1:248489184:A:AG	donor_gain	0.5100
1:248489355:ATG:A	acceptor_gain	0.5100
1:248489013:ATAG:A	donor_gain	0.5000
1:248489272:C:CA	acceptor_gain	0.5000
1:248489147:GCT:G	donor_gain	0.4900
1:248489355:AT:A	acceptor_gain	0.4900
1:248489150:G:GG	donor_gain	0.4800
1:248488921:AGCAG:A	donor_loss	0.4700
1:248488922:GCAG:G	donor_loss	0.4700
1:248488923:CAGGT:C	donor_loss	0.4700
1:248488924:AG:A	donor_loss	0.4700

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1004364676 (1:248491459 T>C), RS1012944521 (1:248491323 A>G), RS1013424144 (1:248487635 G>T), RS1015820625 (1:248488343 A>G), RS1016189830 (1:248491466 G>T), RS1027063626 (1:248491348 A>G), RS1027078419 (1:248487638 T>C), RS1029964127 (1:248491551 G>GA), RS1041643876 (1:248489083 C>A), RS1057095033 (1:248491187 T>C), RS1156574202 (1:248487648 A>AT), RS1156642994 (1:248487481 C>T), RS1158466287 (1:248487981 T>C), RS1159756409 (1:248487903 G>GAA), RS1159953809 (1:248489796 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.