OR2T6

Summary

OR2T6 (olfactory receptor family 2 subfamily T member 6, HGNC:15018) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T6 (Q8NHC8). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 254879 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_001005471

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15018
Approved symbol	OR2T6
Name	olfactory receptor family 2 subfamily T member 6
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	OST703
Ensembl gene	ENSG00000198104
Ensembl biotype	protein_coding
Entrez	254879

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641644

RefSeq mRNA: 1 — MANE Select: NM_001005471 NM_001005471

CCDS: CCDS31114

Canonical transcript exons

ENST00000612137 — 0 exons

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 52.79.

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.79	silver quality
sural nerve	UBERON:0015488	46.14	gold quality
colonic epithelium	UBERON:0000397	42.88	gold quality
superior frontal gyrus	UBERON:0002661	41.67	gold quality
ventricular zone	UBERON:0003053	39.84	gold quality
primary visual cortex	UBERON:0002436	39.00	gold quality
ganglionic eminence	UBERON:0004023	38.79	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
anterior cingulate cortex	UBERON:0009835	36.37	silver quality
bone marrow cell	CL:0002092	36.16	gold quality
bone marrow	UBERON:0002371	34.97	gold quality
monocyte	CL:0000576	34.43	gold quality
leukocyte	CL:0000738	33.81	gold quality
adult mammalian kidney	UBERON:0000082	33.40	silver quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
kidney	UBERON:0002113	33.03	silver quality
putamen	UBERON:0001874	32.70	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
cortex of kidney	UBERON:0001225	31.48	gold quality
nucleus accumbens	UBERON:0001882	31.46	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right lung	UBERON:0002167	30.33	gold quality
calcaneal tendon	UBERON:0003701	30.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
endometrium	UBERON:0001295	29.48	gold quality
heart left ventricle	UBERON:0002084	29.44	gold quality
liver	UBERON:0002107	28.75	gold quality
lymph node	UBERON:0000029	28.68	gold quality
duodenum	UBERON:0002114	28.14	gold quality
blood	UBERON:0000178	27.93	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-7249	no	2.62
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2t6	ENSMUSG00000052417
rattus_norvegicus	Or2t6	ENSRNOG00000084296

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310)

Protein

Protein identifiers

Olfactory receptor 2T6 — Q8NHC8 (reviewed: Q8NHC8)

Alternative names: OST703, Olfactory receptor 2T9

All UniProt accessions (1): Q8NHC8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005471* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NHC8-F1	88.18	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

120 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T6	TAS2R42	Q7RTR8	400
OR2T6	TRIM48	Q8IWZ4	397
OR2T6	YPEL4	Q96NS1	378
OR2T6	THSD7B	Q9C0I4	325
OR2T6	NLRP11	P59045	313
OR2T6	INSL5	Q9Y5Q6	287
OR2T6	LAIR2	Q6ISS4	275
OR2T6	TMEM229A	B2RXF0	265
OR2T6	ATP6V0C	P27449	223
OR2T6	CXXC5	Q7LFL8	220
OR2T6	GOLT1B	Q9Y3E0	214
OR2T6	OR51B4	Q9Y5P0	212
OR2T6	MUC12	Q9UKN1	204
OR2T6	ELOVL2	Q9NXB9	184
OR2T6	PFKFB2	O60825	183

IntAct

2 interactions, top by confidence:

A	B	Type	Score
ALB	CDC45	psi-mi:“MI:0914”(association)	0.350

BioGRID (1): OR2T6 (Affinity Capture-MS)

ESM2 similar proteins: A3KFT3, P0C628, P34982, P34985, P37068, P37071, Q15612, Q60879, Q8N146, Q8N162, Q8N349, Q8NG80, Q8NG81, Q8NG83, Q8NG85, Q8NG92, Q8NG95, Q8NGA1, Q8NGC7, Q8NGC8, Q8NGC9, Q8NGE0, Q8NGG4, Q8NGI8, Q8NGQ6, Q8NGS4, Q8NGY6, Q8NGY9, Q8NGZ0, Q8NGZ9, Q8NH16, Q8NH74, Q8NHA4, Q8NHB7, Q8NHC8, Q8VEX5, Q8VFR8, Q8VFV4, Q8VFX2, Q8VGI4

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	47
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

373 predictions. Top by Δscore:

Variant	Effect	Δscore
1:248388098:A:G	donor_gain	0.7800
1:248388098:A:AG	donor_gain	0.7600
1:248388223:A:AG	acceptor_gain	0.7200
1:248388243:C:CA	acceptor_gain	0.7200
1:248388203:AT:A	donor_gain	0.6900
1:248387974:C:G	donor_gain	0.6700
1:248388146:G:GC	acceptor_gain	0.6700
1:248388223:AAT:A	acceptor_gain	0.6700
1:248388480:GTCT:G	acceptor_gain	0.6600
1:248388145:T:TA	acceptor_gain	0.6500
1:248388228:T:A	acceptor_gain	0.6300
1:248388034:G:GT	donor_gain	0.6200
1:248388246:T:TA	acceptor_gain	0.6200
1:248388023:C:T	donor_gain	0.6000
1:248388145:TG:T	acceptor_gain	0.6000
1:248388231:T:A	acceptor_gain	0.6000
1:248388225:T:TA	acceptor_gain	0.5900
1:248388263:ACCAG:A	acceptor_gain	0.5900
1:248388310:G:GT	donor_gain	0.5800
1:248388479:A:AG	acceptor_gain	0.5800
1:248388480:G:GG	acceptor_gain	0.5800
1:248388143:TGTG:T	acceptor_gain	0.5700
1:248388420:A:G	donor_gain	0.5600
1:248388057:T:A	donor_gain	0.5500
1:248388143:T:TA	acceptor_gain	0.5500
1:248388479:AGTCT:A	acceptor_gain	0.5500
1:248388480:GTCTG:G	acceptor_gain	0.5500
1:248387904:C:G	donor_gain	0.5400
1:248388152:C:G	acceptor_gain	0.5400
1:248388280:A:AG	acceptor_gain	0.5400

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000259636 (1:248376632 T>C,G), RS1000271890 (1:248374032 T>C), RS1000305815 (1:248388677 A>G), RS1000610114 (1:248376810 A>G), RS1000895808 (1:248385390 A>G), RS1000992076 (1:248381270 G>A), RS1001196772 (1:248391048 C>T), RS1001577032 (1:248389990 A>G), RS1001708229 (1:248384863 C>T), RS1001886038 (1:248378276 T>C), RS1002592504 (1:248380593 A>G), RS1002629520 (1:248379182 A>C,G), RS1002774094 (1:248374867 C>T), RS1002953096 (1:248381822 A>G), RS1003088503 (1:248388167 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.