OR2T7

Summary

OR2T7 (olfactory receptor family 2 subfamily T member 7 (gene/pseudogene), HGNC:15019) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T7 (P0C7T2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81458 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15019
Approved symbol	OR2T7
Name	olfactory receptor family 2 subfamily T member 7 (gene/pseudogene)
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	OST723
Ensembl gene	ENSG00000227152
Ensembl biotype	protein_coding
Entrez	81458

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding_LoF

ENST00000641057, ENST00000641557

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000641057 — 2 exons

Exon	Start	End
ENSE00003811623	248441178	248444316
ENSE00003812044	248439145	248439468

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
sural nerve	UBERON:0015488	35.88	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.86	gold quality
monocyte	CL:0000576	33.52	gold quality
leukocyte	CL:0000738	32.99	gold quality
muscle tissue	UBERON:0002385	32.15	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.35	gold quality
liver	UBERON:0002107	28.73	gold quality
tonsil	UBERON:0002372	28.46	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
primary visual cortex	UBERON:0002436	27.33	gold quality
islet of Langerhans	UBERON:0000006	26.89	gold quality
blood	UBERON:0000178	26.88	gold quality
urinary bladder	UBERON:0001255	26.59	gold quality
calcaneal tendon	UBERON:0003701	26.50	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
corpus callosum	UBERON:0002336	25.81	gold quality
kidney	UBERON:0002113	25.31	gold quality
muscle of leg	UBERON:0001383	25.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or8g22	ENSMUSG00000095194
mus_musculus	Or8g29	ENSMUSG00000111190

Protein

Protein identifiers

Olfactory receptor 2T7 — P0C7T2 (reviewed: P0C7T2)

Alternative names: OST723, olfactory receptor OR1-44

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, sequence conflict 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P0C7T2-F1	84.29	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 88–170

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 15 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (1): detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (1): plasma membrane (GO:0005886)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NL26, O43749, O76001, O76002, O76100, O95006, P0C7T2, P0DMU2, P23272, P23274, P30955, P58173, P59922, P70526, Q13607, Q60890, Q6IEU7, Q6IEZ7, Q6IF00, Q6IF36, Q6UXT6, Q8NGE5, Q8NGI7, Q8NGL2, Q8NGN7, Q8NGP8, Q8NGQ2, Q8NGS0, Q8NGS2, Q8NGX2, Q8NGX3, Q8NGZ4, Q8NGZ5, Q8NH01, Q8NH02, Q8NH04, Q8NH80, Q8NHA6, Q8VEY3, Q8VG44

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001327776 (1:248436715 A>G,T), RS1001736370 (1:248435752 TA>T), RS1003673349 (1:248439817 A>G), RS1003832370 (1:248440123 C>T), RS1004068312 (1:248440090 A>G,T), RS1005121157 (1:248441379 C>A,T), RS1006120834 (1:248443421 C>CT), RS1006176648 (1:248442657 C>G), RS1007677419 (1:248444306 G>T), RS1008132632 (1:248438289 C>T), RS1008142778 (1:248437011 T>A,C), RS1009591156 (1:248439794 T>C), RS1009685462 (1:248439390 G>A), RS1009971359 (1:248435473 C>A,T), RS1010022293 (1:248434453 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.