OR2T8

Summary

OR2T8 (olfactory receptor family 2 subfamily T member 8, HGNC:15020) is a protein-coding gene on chromosome 1q44, encoding Olfactory receptor 2T8 (A6NH00). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 343172 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 57 total
• MANE Select transcript: NM_001005522

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15020
Approved symbol	OR2T8
Name	olfactory receptor family 2 subfamily T member 8
Location	1q44
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000177462
Ensembl biotype	protein_coding
Entrez	343172

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641945

RefSeq mRNA: 1 — MANE Select: NM_001005522 NM_001005522

CCDS: CCDS31100

Canonical transcript exons

ENST00000641945 — 2 exons

Exon	Start	End
ENSE00003811962	247920998	247923152
ENSE00003814110	247920252	247920518

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 81.39.

Top tissues by expression

106 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.39	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.70	silver quality
right lobe of thyroid gland	UBERON:0001119	57.35	gold quality
left lobe of thyroid gland	UBERON:0001120	56.74	gold quality
thyroid gland	UBERON:0002046	56.43	gold quality
superior frontal gyrus	UBERON:0002661	50.56	gold quality
cortical plate	UBERON:0005343	48.65	gold quality
primary visual cortex	UBERON:0002436	48.04	silver quality
bone marrow	UBERON:0002371	46.68	gold quality
tibial nerve	UBERON:0001323	46.57	gold quality
right uterine tube	UBERON:0001302	45.31	silver quality
bone marrow cell	CL:0002092	44.38	gold quality
prefrontal cortex	UBERON:0000451	42.95	gold quality
hypothalamus	UBERON:0001898	42.92	gold quality
nucleus accumbens	UBERON:0001882	42.49	gold quality
placenta	UBERON:0001987	42.18	gold quality
sural nerve	UBERON:0015488	42.18	gold quality
frontal cortex	UBERON:0001870	41.63	gold quality
Brodmann (1909) area 9	UBERON:0013540	41.10	silver quality
blood	UBERON:0000178	40.61	gold quality
stromal cell of endometrium	CL:0002255	40.14	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	39.99	gold quality
anterior cingulate cortex	UBERON:0009835	39.87	gold quality
cerebral cortex	UBERON:0000956	39.58	gold quality
right frontal lobe	UBERON:0002810	39.25	gold quality
substantia nigra	UBERON:0002038	39.19	gold quality
endocervix	UBERON:0000458	37.79	gold quality
caudate nucleus	UBERON:0001873	37.45	gold quality
monocyte	CL:0000576	37.32	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.13

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2t44	ENSMUSG00000059504
rattus_norvegicus	Or2t44b	ENSRNOG00000033492
rattus_norvegicus	Or2t44	ENSRNOG00000084778
rattus_norvegicus	Olr1454	ENSRNOG00000089012

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR2V2 (ENSG00000182613), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2T8 — A6NH00 (reviewed: A6NH00)

All UniProt accessions (1): A6NH00

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005522* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (27 total): topological domain 8, sequence variant 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NH00-F1	88.59	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–177

Glycosylation sites (2): 3, 17

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr1q44, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, VAN_DEN_BIGGELAAR_PBMC_PREVNAR_9MO_INFANT_STIMULATED_VS_UNSTIMULATED_8MO_UP, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

124 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2T8	TRIM58	Q8NG06	659
OR2T8	CCDC28A-AS1	A0A096LPI5	447
OR2T8	HIGD2B	Q4VC39	417
OR2T8	PRAMEF2	O60811	407
OR2T8	ZNF250	P15622	370
OR2T8	GPATCH4	Q5T3I0	367
OR2T8	FAM98B	Q52LJ0	327
OR2T8	Q8N1N5	Q8N1N5	326
OR2T8	EHMT1	Q9H9B1	324
OR2T8	TMEM219	Q86XT9	305
OR2T8	CPAMD8	Q8IZJ3	305
OR2T8	GPR160	Q9UJ42	278
OR2T8	UBQLN3	Q9H347	271
OR2T8	FAM218A	Q96MZ4	270
OR2T8	C9orf85	Q96MD7	266

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	9
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

331 predictions. Top by Δscore:

Variant	Effect	Δscore
1:247921664:AT:A	acceptor_gain	0.7800
1:247921665:T:TA	acceptor_gain	0.7700
1:247921608:G:GG	donor_gain	0.7000
1:247921665:T:G	acceptor_gain	0.6900
1:247921274:G:GT	donor_gain	0.6800
1:247921560:GCTG:G	donor_gain	0.6800
1:247921564:G:GG	donor_gain	0.6700
1:247921277:G:GG	donor_gain	0.6600
1:247921336:G:GA	donor_gain	0.6500
1:247921664:A:AG	acceptor_gain	0.6400
1:247921677:C:CA	acceptor_gain	0.6400
1:247921562:TGGT:T	donor_loss	0.6300
1:247921563:GGTG:G	donor_loss	0.6300
1:247921564:GTG:G	donor_loss	0.6300
1:247921565:T:A	donor_loss	0.6300
1:247921566:GCGT:G	donor_loss	0.6300
1:247921335:T:TA	donor_gain	0.6200
1:247921567:CGTT:C	donor_loss	0.6200
1:247921883:GT:G	acceptor_gain	0.6200
1:247921568:G:C	donor_loss	0.6100
1:247921603:GCCAT:G	donor_gain	0.6000
1:247921102:GTTC:G	donor_gain	0.5900
1:247921103:TTCT:T	donor_gain	0.5900
1:247921616:GCT:G	donor_gain	0.5900
1:247921652:T:G	acceptor_gain	0.5900
1:247921704:A:AG	acceptor_gain	0.5900
1:247921705:G:GG	acceptor_gain	0.5900
1:247921274:GAA:G	donor_gain	0.5800
1:247921664:ATG:A	acceptor_gain	0.5700
1:247921274:G:T	donor_gain	0.5600

AlphaMissense

2036 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:247921762:T:C	F249L	0.863
1:247921764:T:A	F249L	0.863
1:247921764:T:G	F249L	0.863
1:247921540:T:C	F175L	0.861
1:247921542:C:A	F175L	0.861
1:247921542:C:G	F175L	0.861
1:247921045:T:C	F10L	0.842
1:247921047:C:A	F10L	0.842
1:247921047:C:G	F10L	0.842
1:247921594:T:C	F193L	0.836
1:247921596:C:A	F193L	0.836
1:247921596:C:G	F193L	0.836
1:247921365:G:A	M116I	0.827
1:247921365:G:C	M116I	0.827
1:247921365:G:T	M116I	0.827
1:247921882:A:C	S289R	0.824
1:247921884:T:A	S289R	0.824
1:247921884:T:G	S289R	0.824
1:247921543:T:C	F176L	0.809
1:247921545:C:A	F176L	0.809
1:247921545:C:G	F176L	0.809
1:247921063:T:C	F16L	0.800
1:247921065:T:A	F16L	0.800
1:247921065:T:G	F16L	0.800
1:247921840:T:C	F275L	0.781
1:247921842:C:A	F275L	0.781
1:247921842:C:G	F275L	0.781
1:247921376:G:C	R120P	0.779
1:247921108:A:C	S31R	0.773
1:247921110:T:A	S31R	0.773

dbSNP variants (sampled 300 via entrez): RS1000980640 (1:247922584 A>C), RS1001160008 (1:247922165 C>T), RS1001315150 (1:247918657 C>A,T), RS1002879811 (1:247918394 G>A,T), RS1003877523 (1:247918451 T>G), RS1004096679 (1:247918712 C>A), RS1004148961 (1:247918955 T>C,G), RS1005469311 (1:247918574 C>T), RS1005765030 (1:247920054 G>T), RS1005878001 (1:247921647 C>T), RS1005959970 (1:247919822 A>C), RS1006330938 (1:247919572 G>T), RS1006511215 (1:247921857 C>T), RS1006690562 (1:247919888 C>T), RS1006999402 (1:247922231 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006633_2	Initial alcohol sensitivity	6.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation	1
Benzo(a)pyrene	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.