OR2V2

Summary

OR2V2 (olfactory receptor family 2 subfamily V member 2, HGNC:15341) is a protein-coding gene on chromosome 5q35.3, encoding Olfactory receptor 2V2 (Q96R30). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 285659 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_206880

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15341
Approved symbol	OR2V2
Name	olfactory receptor family 2 subfamily V member 2
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Aliases	OST713
Ensembl gene	ENSG00000182613
Ensembl biotype	protein_coding
Entrez	285659

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641492, ENST00000641791

RefSeq mRNA: 1 — MANE Select: NM_206880 NM_206880

CCDS: CCDS4461

Canonical transcript exons

ENST00000641492 — 2 exons

Exon	Start	End
ENSE00003812164	181154919	181159285
ENSE00003812569	181147586	181147995

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 55.07.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	55.07	gold quality
sural nerve	UBERON:0015488	52.17	gold quality
ventricular zone	UBERON:0003053	43.24	gold quality
hindlimb stylopod muscle	UBERON:0004252	41.86	gold quality
skeletal muscle tissue	UBERON:0001134	41.74	gold quality
bone marrow	UBERON:0002371	40.71	gold quality
calcaneal tendon	UBERON:0003701	40.66	gold quality
muscle tissue	UBERON:0002385	40.44	gold quality
cortical plate	UBERON:0005343	39.92	gold quality
stromal cell of endometrium	CL:0002255	39.10	gold quality
monocyte	CL:0000576	39.01	gold quality
blood	UBERON:0000178	38.87	gold quality
leukocyte	CL:0000738	38.45	gold quality
fallopian tube	UBERON:0003889	38.17	gold quality
primary visual cortex	UBERON:0002436	38.16	gold quality
lower esophagus mucosa	UBERON:0035834	37.49	gold quality
vermiform appendix	UBERON:0001154	37.46	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ganglionic eminence	UBERON:0004023	37.10	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
liver	UBERON:0002107	36.09	gold quality
apex of heart	UBERON:0002098	35.82	gold quality
muscle of leg	UBERON:0001383	35.11	gold quality
cortex of kidney	UBERON:0001225	34.96	gold quality
corpus callosum	UBERON:0002336	34.81	gold quality
mucosa of transverse colon	UBERON:0004991	34.74	gold quality
prefrontal cortex	UBERON:0000451	34.33	gold quality
adrenal tissue	UBERON:0018303	34.31	gold quality
right coronary artery	UBERON:0001625	34.25	gold quality
granulocyte	CL:0000094	34.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or2v2	ENSMUSG00000047511
rattus_norvegicus	Or2v2c	ENSRNOG00000085994
rattus_norvegicus	Or2v2	ENSRNOG00000089191
rattus_norvegicus	Or2v2b	ENSRNOG00000090718

Paralogs (92): OR2B6 (ENSG00000124657), OR13C9 (ENSG00000136839), OR13C4 (ENSG00000148136), OR2M5 (ENSG00000162727), OR10A5 (ENSG00000166363), OR2D2 (ENSG00000166368), OR2B2 (ENSG00000168131), OR2C1 (ENSG00000168158), OR13J1 (ENSG00000168828), OR10G3 (ENSG00000169208), OR10A3 (ENSG00000170683), OR10A4 (ENSG00000170782), OR10A2 (ENSG00000170790), OR13H1 (ENSG00000171054), OR2K2 (ENSG00000171133), OR2M4 (ENSG00000171180), OR10H2 (ENSG00000171942), OR10H5 (ENSG00000172519), OR10AD1 (ENSG00000172640), OR2Y1 (ENSG00000174339), OR10AG1 (ENSG00000174970), OR2T1 (ENSG00000175143), OR10P1 (ENSG00000175398), OR2T35 (ENSG00000177151), OR2M7 (ENSG00000177186), OR2T12 (ENSG00000177201), OR2T33 (ENSG00000177212), OR2AJ1 (ENSG00000177275), OR2T8 (ENSG00000177462), OR2G3 (ENSG00000177476), OR2G2 (ENSG00000177489), OR2B11 (ENSG00000177535), OR2D3 (ENSG00000178358), OR13D1 (ENSG00000179055), OR10A7 (ENSG00000179919), OR2Z1 (ENSG00000181733), OR10G7 (ENSG00000182634), OR2T29 (ENSG00000182783), OR2T34 (ENSG00000183310), OR2T10 (ENSG00000184022)

Protein

Protein identifiers

Olfactory receptor 2V2 — Q96R30 (reviewed: Q96R30)

Alternative names: Olfactory receptor 2V3, Olfactory receptor OR5-3

All UniProt accessions (1): Q96R30

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_996763* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96R30-F1	81.97	0.36

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, SCHERER_PBMC_APSV_WETVAX_AGE_18_32YO_2_TO_4DY_UP, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): detection of chemical stimulus involved in sensory perception of smell (GO:0050911), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

78 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR2V2	SDK1	Q7Z5N4	580
OR2V2	FAM117A	Q9C073	424
OR2V2	SKA2	Q8WVK7	418
OR2V2	EIF3B	P55884	323
OR2V2	MON1B	Q7L1V2	322
OR2V2	ZNF496	Q96IT1	315
OR2V2	TSSK6	Q9BXA6	249
OR2V2	LRFN2	Q9ULH4	248
OR2V2	CHST12	Q9NRB3	246
OR2V2	CACNA1C	Q13936	205
OR2V2	SOSTDC1	Q6X4U4	198
OR2V2	OVOL2	Q9BRP0	194
OR2V2	ANXA1	P04083	194
OR2V2	DERL1	Q9BUN8	185
OR2V2	MAGEL2	Q9UJ55	180

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A4D2G3, O60403, O76001, O76002, O76100, O95006, O95047, P23269, P23272, P23274, P30953, P30955, P34984, P58173, P59922, P70526, Q13607, Q15619, Q15622, Q5TZ20, Q60890, Q6IF42, Q7Z3T1, Q8N628, Q8NGA6, Q8NGQ2, Q8NGT7, Q8NGT9, Q8NGX0, Q8NGY5, Q8NGZ4, Q8NGZ5, Q8NGZ6, Q8NHA6, Q8VGD6, Q8VGI1, Q95156, Q96R30, Q96R45, Q96R47

Diamond homologs: A3KFT3, A4D2G3, A6NH00, A6NL26, A6NM03, O43869, O76000, O76001, O76002, O95006, O95221, O95371, O95918, P0C7N1, P0C7T2, P23274, P23275, P34984, P59922, Q13606, Q13607, Q5TZ20, Q60880, Q60890, Q6IEZ7, Q6IF00, Q8N127, Q8N349, Q8N628, Q8NG75, Q8NG76, Q8NG77, Q8NG80, Q8NG81, Q8NG83, Q8NG84, Q8NG85, Q8NG97, Q8NGC0, Q8NGE5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	8
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

279 predictions. Top by Δscore:

Variant	Effect	Δscore
5:181155212:G:GT	donor_gain	0.9800
5:181155212:G:T	donor_gain	0.8500
5:181155461:G:GT	donor_gain	0.7800
5:181155007:G:GG	donor_gain	0.7700
5:181155462:A:T	donor_gain	0.7600
5:181155006:A:AG	donor_gain	0.7300
5:181155069:A:T	donor_gain	0.7300
5:181155213:A:T	donor_gain	0.7200
5:181155209:C:T	donor_gain	0.7100
5:181155605:C:G	acceptor_gain	0.7100
5:181155485:GATGC:G	donor_gain	0.6900
5:181155121:T:G	donor_gain	0.6500
5:181155428:G:GA	donor_gain	0.6400
5:181155533:GAAG:G	donor_gain	0.6400
5:181155606:A:AG	acceptor_gain	0.6400
5:181155160:T:G	donor_gain	0.6300
5:181155817:GCTT:G	acceptor_gain	0.6200
5:181154993:C:T	donor_gain	0.6100
5:181155430:T:TA	donor_gain	0.6100
5:181155431:A:AA	donor_gain	0.6100
5:181155068:G:T	donor_gain	0.5900
5:181155816:A:AG	acceptor_gain	0.5900
5:181155817:G:GG	acceptor_gain	0.5900
5:181154957:GAACC:G	donor_gain	0.5700
5:181154958:AACCA:A	donor_gain	0.5700
5:181155427:T:TA	donor_gain	0.5700
5:181155432:G:GG	donor_gain	0.5600
5:181155532:AGAAG:A	donor_loss	0.5600
5:181155534:AAG:A	donor_loss	0.5600
5:181155535:AG:A	donor_loss	0.5600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000052187 (5:181149012 G>A), RS1000078764 (5:181146780 C>T), RS1000177698 (5:181151803 G>A,T), RS1000384839 (5:181157200 G>C), RS1000576614 (5:181155843 G>A,C,T), RS1000756643 (5:181145634 C>T), RS1001248131 (5:181158804 T>C), RS1001322812 (5:181151010 G>A), RS1001354536 (5:181155767 C>A,G), RS1001385394 (5:181158517 C>T), RS1001491414 (5:181156034 C>T), RS1002181667 (5:181149449 A>C,G), RS1002317367 (5:181149733 G>T), RS1002324725 (5:181148039 A>C), RS1002349003 (5:181154446 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007681_4	Thyroid stimulating hormone levels	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
butyraldehyde	increases expression	1
pentanal	increases expression	1
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Endosulfan	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.