OR3A2

Summary

OR3A2 (olfactory receptor family 3 subfamily A member 2, HGNC:8283) is a protein-coding gene on chromosome 17p13.3, encoding Olfactory receptor 3A2 (P47893). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 4995 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 53 total
• MANE Select transcript: NM_002551

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8283
Approved symbol	OR3A2
Name	olfactory receptor family 3 subfamily A member 2
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	OLFRA04, OR228, OR17-228
Ensembl gene	ENSG00000221882
Ensembl biotype	protein_coding
Entrez	4995

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 protein_coding

ENST00000573491, ENST00000573901, ENST00000576166, ENST00000641164, ENST00000642052, ENST00000869173, ENST00000869174, ENST00000961576, ENST00000961577, ENST00000961578

RefSeq mRNA: 1 — MANE Select: NM_002551 NM_002551

CCDS: CCDS42233

Canonical transcript exons

ENST00000573901 — 5 exons

Exon	Start	End
ENSE00002659222	3336029	3336126
ENSE00002669129	3284358	3284551
ENSE00003811896	3386125	3386308
ENSE00003997520	3276177	3278923
ENSE00003997521	3279076	3279153

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 83.08.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1994 / max 25.4651, expressed in 92 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163844	0.1994	92

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.08	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.58	gold quality
right testis	UBERON:0004534	67.76	gold quality
left testis	UBERON:0004533	67.26	gold quality
testis	UBERON:0000473	66.16	gold quality
pancreatic ductal cell	CL:0002079	64.51	silver quality
islet of Langerhans	UBERON:0000006	57.72	gold quality
nasal cavity epithelium	UBERON:0005384	56.65	gold quality
cortical plate	UBERON:0005343	56.58	gold quality
decidua	UBERON:0002450	56.55	gold quality
parotid gland	UBERON:0001831	56.24	gold quality
ventricular zone	UBERON:0003053	54.29	gold quality
nucleus accumbens	UBERON:0001882	54.26	gold quality
sural nerve	UBERON:0015488	53.99	silver quality
caudate nucleus	UBERON:0001873	53.03	gold quality
granulocyte	CL:0000094	52.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	52.54	gold quality
hair follicle	UBERON:0002073	52.43	gold quality
prefrontal cortex	UBERON:0000451	52.19	gold quality
putamen	UBERON:0001874	52.10	gold quality
epithelial cell of pancreas	CL:0000083	51.98	gold quality
Brodmann (1909) area 46	UBERON:0006483	51.71	gold quality
hypothalamus	UBERON:0001898	51.61	gold quality
spinal cord	UBERON:0002240	51.43	gold quality
quadriceps femoris	UBERON:0001377	50.60	gold quality
substantia nigra	UBERON:0002038	50.28	gold quality
vastus lateralis	UBERON:0001379	50.22	gold quality
deltoid	UBERON:0001476	50.04	silver quality
lymph node	UBERON:0000029	49.74	gold quality
Brodmann (1909) area 9	UBERON:0013540	49.38	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.41

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 3A2 — P47893 (reviewed: P47893)

Alternative names: Olfactory receptor 17-228, Olfactory receptor OR17-14

All UniProt accessions (3): A0A286YF44, A0A286YF70, A0A286YFF0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_002542* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence conflict 4, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P47893-F1	85.25	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 106–198

Glycosylation sites (1): 14

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 33 (showing top): RNGTGGGC_UNKNOWN, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, TGACCTY_ERR1_Q2, GGCNKCCATNK_UNKNOWN, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, IRF1_01, DCA_UP.V1_UP

GO Biological Process (5): signal transduction (GO:0007165), sensory perception of chemical stimulus (GO:0007606), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
sensory perception	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

304 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR3A2	KRTAP9-7	A8MTY7	601
OR3A2	CDRT15L2	A8MXV6	590
OR3A2	TBC1D28	Q2M2D7	513
OR3A2	KRTAP9-8	Q9BYQ0	507
OR3A2	SLC35G3	Q8N808	505
OR3A2	SLC35G6	P0C7Q6	505
OR3A2	CCDC144A	A2RUR9	480
OR3A2	DYTN	A2CJ06	480
OR3A2	SPDYE4	A6NLX3	477
OR3A2	KRTAP9-1	A8MXZ3	477
OR3A2	CHCT1	Q86WR6	474
OR3A2	TBC1D26	Q86UD7	472
OR3A2	TPK1	Q9H3S4	463
OR3A2	SPAG6	O75602	461
OR3A2	PRKAG3	Q9UGI9	458

IntAct

2 interactions, top by confidence:

A	B	Type	Score
ALB	SH3BP5	psi-mi:“MI:0914”(association)	0.350

BioGRID (2): OR3A2 (Affinity Capture-MS), OR3A2 (Affinity Capture-MS)

ESM2 similar proteins: A6NH00, O60403, O95371, O95918, P23266, P23267, P23275, P34984, P47881, P47888, P47893, Q15619, Q5JQS5, Q5TZ20, Q60885, Q60891, Q60894, Q6IEZ7, Q7Z3T1, Q8N628, Q8NG76, Q8NG77, Q8NG97, Q8NGA6, Q8NGC4, Q8NGE3, Q8NGE9, Q8NGQ2, Q8NGQ4, Q8NGR4, Q8NGS0, Q8NGT9, Q8NGX9, Q8NGY1, Q8NGZ6, Q8NH02, Q8NH03, Q8NH04, Q8NHB1, Q8VGD6

Diamond homologs: A4D2G3, A6NL26, O14581, O43749, O60431, O76100, O95221, P0C626, P0C7N5, P23265, P23266, P23274, P30953, P30955, P34985, P37070, P47881, P47883, P47888, P47890, P47893, P58173, P70526, Q15617, Q15619, Q15620, Q15622, Q60881, Q60882, Q60886, Q60890, Q60891, Q60895, Q6IEU7, Q8N127, Q8NG98, Q8NGA1, Q8NGF4, Q8NGG6, Q8NGG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

668 predictions. Top by Δscore:

Variant	Effect	Δscore
17:3291761:AT:A	donor_gain	0.7800
17:3291811:CTG:C	donor_gain	0.7800
17:3278693:T:TA	donor_gain	0.7600
17:3291913:C:CT	acceptor_gain	0.7600
17:3292330:A:C	donor_gain	0.7600
17:3291810:CCT:C	donor_gain	0.7500
17:3291914:G:C	acceptor_gain	0.7500
17:3291807:ATACC:A	acceptor_loss	0.7300
17:3291808:TACCT:T	acceptor_loss	0.7300
17:3291809:ACCT:A	acceptor_loss	0.7300
17:3291810:CC:C	acceptor_loss	0.7300
17:3291811:CT:C	acceptor_loss	0.7300
17:3291812:T:G	acceptor_loss	0.7300
17:3292259:A:C	acceptor_gain	0.7300
17:3291812:TGA:T	donor_gain	0.7000
17:3278222:A:C	donor_gain	0.6800
17:3278285:G:A	donor_gain	0.6700
17:3278360:C:A	acceptor_gain	0.6700
17:3278152:C:CT	acceptor_gain	0.6600
17:3291817:C:CT	acceptor_gain	0.6600
17:3291817:CA:C	acceptor_loss	0.6600
17:3291832:C:CT	donor_gain	0.6600
17:3291871:T:TA	donor_gain	0.6600
17:3278303:C:T	acceptor_gain	0.6500
17:3278148:C:G	acceptor_gain	0.6300
17:3291825:A:C	acceptor_loss	0.6300
17:3292256:C:CT	acceptor_gain	0.6300
17:3278304:A:AC	donor_gain	0.6200
17:3278305:C:CC	donor_gain	0.6200
17:3278248:CGTGG:C	acceptor_gain	0.6100

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000037152 (17:3372840 A>G), RS1000052715 (17:3364223 T>C), RS1000056476 (17:3338182 G>A), RS1000098775 (17:3378123 G>A), RS1000104495 (17:3277800 T>C,G), RS1000105503 (17:3336317 A>T), RS1000109280 (17:3320370 C>A), RS1000131412 (17:3378322 T>C), RS1000159618 (17:3285893 T>C), RS1000190723 (17:3350007 A>C), RS1000192962 (17:3383038 C>T), RS1000228057 (17:3386339 C>T), RS1000264568 (17:3281919 G>C), RS1000315541 (17:3276796 C>A,T), RS1000330479 (17:3365770 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002142_13	Cocaine dependence	4.000000e-07
GCST002142_7	Cocaine dependence	2.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.