OR4A16

Summary

OR4A16 (olfactory receptor family 4 subfamily A member 16, HGNC:15153) is a protein-coding gene on chromosome 11q11, encoding Olfactory receptor 4A16 (Q8NH70). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81327 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 70 total
• MANE Select transcript: NM_001005274

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15153
Approved symbol	OR4A16
Name	olfactory receptor family 4 subfamily A member 16
Location	11q11
Locus type	gene with protein product
Status	Approved
Aliases	OR4A16Q
Ensembl gene	ENSG00000181961
Ensembl biotype	protein_coding
Entrez	81327

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000314721

RefSeq mRNA: 1 — MANE Select: NM_001005274 NM_001005274

CCDS: CCDS31499

Canonical transcript exons

ENST00000314721 — 1 exons

Exon	Start	End
ENSE00001272986	55343201	55344187

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 82.82.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.82	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
skeletal muscle tissue	UBERON:0001134	35.54	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
muscle tissue	UBERON:0002385	32.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	29.17	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.88	gold quality
monocyte	CL:0000576	26.81	gold quality
urinary bladder	UBERON:0001255	26.79	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.05	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
right lobe of liver	UBERON:0001114	25.29	gold quality
muscle of leg	UBERON:0001383	25.06	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

20 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4a81	ENSMUSG00000075074
mus_musculus	Or4a77	ENSMUSG00000075078
mus_musculus	Or4a74	ENSMUSG00000075081
mus_musculus	Or4a71	ENSMUSG00000075084
mus_musculus	Or4a70	ENSMUSG00000075085
mus_musculus	Or4a69	ENSMUSG00000075086
mus_musculus	Or4a79	ENSMUSG00000110819
mus_musculus	Or4a68	ENSMUSG00000111174
mus_musculus	Or4a75	ENSMUSG00000111239
mus_musculus	Or4a72	ENSMUSG00000111456
rattus_norvegicus	Or4a68	ENSRNOG00000073848
rattus_norvegicus	Or4a77	ENSRNOG00000074893
rattus_norvegicus	Or4a77d	ENSRNOG00000075538
rattus_norvegicus	Or4a70	ENSRNOG00000077316
rattus_norvegicus	Or4a77b	ENSRNOG00000078695
rattus_norvegicus	Or4a77e	ENSRNOG00000079238
rattus_norvegicus	Or4a72	ENSRNOG00000079636
rattus_norvegicus	Or4a77c	ENSRNOG00000083097
rattus_norvegicus	Or4a69	ENSRNOG00000089236
rattus_norvegicus	Or4a81	ENSRNOG00000089840

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4A16 — Q8NH70 (reviewed: Q8NH70)

Alternative names: Olfactory receptor OR11-117

All UniProt accessions (2): Q8NH70, A0A126GW87

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005274* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH70-F1	85.89	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, chr11q11, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4A16	TRIM48	Q8IWZ4	399
OR4A16	TRIM51	Q9BSJ1	379
OR4A16	AK9	Q5TCS8	348
OR4A16	TRIM58	Q8NG06	305
OR4A16	PLBD1	Q6P4A8	288
OR4A16	ZNF737	O75373	285
OR4A16	MMAB	Q96EY8	275
OR4A16	KRTAP9-1	A8MXZ3	266
OR4A16	ZRANB2	O95218	260
OR4A16	DEGS2	Q6QHC5	254
OR4A16	FXYD3	Q14802	246
OR4A16	IQGAP3	Q86VI3	242
OR4A16	OR51F2	Q8NH61	239
OR4A16	CFAP47	Q6ZTR5	221
OR4A16	KRTAP9-2	Q9BYQ4	220

IntAct

2 interactions, top by confidence:

A	B	Type	Score
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350

BioGRID (1): OR4A16 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60878, Q60881, Q6IEV9, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD1, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGM8, Q8NGN0, Q8NGN8, Q8NGP0, Q8NH05, Q8NH37, Q8NH42

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

70 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

218 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55343337:C:G	donor_gain	0.7200
11:55343370:T:G	donor_gain	0.6100
11:55343220:T:G	donor_gain	0.5600
11:55343835:T:A	acceptor_gain	0.5300
11:55343848:TG:T	donor_gain	0.5300
11:55343849:GG:G	donor_gain	0.5300
11:55344061:G:GC	acceptor_gain	0.5300
11:55343253:A:G	donor_gain	0.5200
11:55343258:G:GT	donor_gain	0.5200
11:55343839:A:AG	acceptor_gain	0.5200
11:55344161:A:AG	acceptor_gain	0.5200
11:55344162:G:GG	acceptor_gain	0.5200
11:55343258:GAT:G	donor_gain	0.5100
11:55343965:G:GG	donor_gain	0.5000
11:55343261:G:GG	donor_gain	0.4900
11:55343632:G:GA	donor_gain	0.4900
11:55343736:T:G	acceptor_gain	0.4900
11:55343260:T:G	donor_gain	0.4800
11:55343374:C:CG	donor_gain	0.4800
11:55343631:T:TA	donor_gain	0.4800
11:55343885:G:GT	donor_gain	0.4700
11:55343893:GCA:G	donor_gain	0.4600
11:55343457:A:AG	donor_gain	0.4500
11:55343375:T:G	donor_gain	0.4400
11:55343687:A:AG	acceptor_gain	0.4400
11:55343688:G:GG	acceptor_gain	0.4400
11:55343927:ATTGT:A	donor_gain	0.4400
11:55343961:T:TG	donor_gain	0.4400
11:55343327:ATTTG:A	donor_gain	0.4300
11:55343331:G:GA	donor_gain	0.4300

AlphaMissense

2157 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55343228:T:C	F10L	0.756
11:55343230:T:A	F10L	0.756
11:55343230:T:G	F10L	0.756
11:55343945:T:C	F249L	0.710
11:55343947:T:A	F249L	0.710
11:55343947:T:G	F249L	0.710
11:55343285:T:C	F29L	0.570
11:55343287:T:A	F29L	0.570
11:55343287:T:G	F29L	0.570

dbSNP variants (sampled 300 via entrez): RS1000322838 (11:55341272 C>T), RS1004671147 (11:55341793 G>C), RS1004737102 (11:55342834 T>C), RS1005335990 (11:55344310 T>A,C,G), RS1006914370 (11:55344447 C>A,T), RS1007082286 (11:55341322 A>C,T), RS1007134559 (11:55341533 A>G), RS1008596147 (11:55342535 G>A), RS1010705888 (11:55341508 G>A,T), RS1011091844 (11:55343505 A>C,G), RS1011296185 (11:55342488 T>C,G), RS1011826302 (11:55342166 T>C), RS1017103356 (11:55344323 A>C,G), RS1017246378 (11:55341323 C>T), RS1023952416 (11:55341949 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005984_55	Glomerular filtration rate	7.000000e-09
GCST005985_34	Creatinine levels	1.000000e-08
GCST009725_46	Intraocular pressure	2.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
bisphenol S	increases methylation	1
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.