OR4A5

Summary

OR4A5 (olfactory receptor family 4 subfamily A member 5, HGNC:15162) is a protein-coding gene on chromosome 11q11, encoding Olfactory receptor 4A5 (Q8NH83). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81318 — RefSeq curated summary.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 97 total
• MANE Select transcript: NM_001005272

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15162
Approved symbol	OR4A5
Name	olfactory receptor family 4 subfamily A member 5
Location	11q11
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000221840
Ensembl biotype	protein_coding
Entrez	81318

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000319760

RefSeq mRNA: 1 — MANE Select: NM_001005272 NM_001005272

CCDS: CCDS73289

Canonical transcript exons

ENST00000319760 — 1 exons

Exon	Start	End
ENSE00001260165	54706832	54707902

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 41.81.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	41.81	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
monocyte	CL:0000576	28.66	gold quality
leukocyte	CL:0000738	28.56	gold quality
liver	UBERON:0002107	28.32	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.79	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.19	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.87	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.41	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
frontal cortex	UBERON:0001870	23.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4a80	ENSMUSG00000075075
mus_musculus	Or4a39	ENSMUSG00000111517
mus_musculus	Or4a78	ENSMUSG00000111567
mus_musculus	Or4a73	ENSMUSG00000111715
rattus_norvegicus	Or4a71	ENSRNOG00000075945
rattus_norvegicus	Olr703	ENSRNOG00000077206
rattus_norvegicus	Or4a73	ENSRNOG00000081630
rattus_norvegicus	Olr716	ENSRNOG00000082792
rattus_norvegicus	Or4a78	ENSRNOG00000090357

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4A5 — Q8NH83 (reviewed: Q8NH83)

Alternative names: Olfactory receptor OR11-111

All UniProt accessions (2): A0A126GWJ2, Q8NH83

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005272* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 3, sequence conflict 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH83-F1	88.44	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–186

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, chr11q11, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4A5	GGTLC2	Q14390	448
OR4A5	SPSB3	Q6PJ21	419
OR4A5	TRIM48	Q8IWZ4	417
OR4A5	ZFP14	Q9HCL3	392
OR4A5	PGLS	O95336	348
OR4A5	BAIAP3	O94812	348
OR4A5	FGGY	Q96C11	326
OR4A5	MTMR7	Q9Y216	321
OR4A5	SPECC1L	Q69YQ0	318
OR4A5	POTED	Q86YR6	311
OR4A5	RPIA	P49247	305
OR4A5	ECI2	O75521	305
OR4A5	PPP1R13B	Q96KQ4	301
OR4A5	GEMIN6	Q8WXD5	300
OR4A5	ACYP2	P14621	287

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

97 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	91
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

185 predictions. Top by Δscore:

Variant	Effect	Δscore
11:54707052:A:C	donor_gain	0.6600
11:54707602:G:GA	donor_gain	0.6300
11:54706935:T:TA	donor_gain	0.5800
11:54707019:T:C	donor_gain	0.5700
11:54707117:A:C	donor_gain	0.5600
11:54706990:TGT:T	donor_gain	0.5400
11:54706991:CTG:C	donor_gain	0.5400
11:54707329:T:TA	donor_gain	0.5400
11:54707604:C:CC	donor_gain	0.5400
11:54707605:A:AC	donor_gain	0.5400
11:54706941:C:CC	donor_gain	0.5300
11:54706942:A:AC	donor_gain	0.5300
11:54706994:CCA:C	donor_gain	0.5300
11:54707208:T:TG	acceptor_gain	0.5300
11:54707409:CAA:C	acceptor_gain	0.5300
11:54707411:CACAA:C	acceptor_gain	0.5300
11:54707406:C:CC	acceptor_gain	0.5200
11:54706993:CAC:C	donor_gain	0.5100
11:54707201:C:CT	acceptor_gain	0.5100
11:54707574:CCCCT:C	donor_gain	0.5000
11:54707808:CCTA:C	acceptor_loss	0.4900
11:54707018:C:CT	donor_gain	0.4800
11:54707806:T:C	acceptor_loss	0.4800
11:54706939:AGGAT:A	donor_gain	0.4700
11:54707315:C:CT	donor_gain	0.4600
11:54707634:CAGG:C	donor_gain	0.4600
11:54707256:C:CC	donor_gain	0.4500
11:54707257:A:AC	donor_gain	0.4500
11:54706943:CACCA:C	donor_loss	0.4400
11:54706944:ACAC:A	donor_loss	0.4400

AlphaMissense

2078 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:54706912:T:C	F10L	0.823
11:54706914:T:A	F10L	0.823
11:54706914:T:G	F10L	0.823
11:54707377:T:C	F165L	0.801
11:54707379:C:A	F165L	0.801
11:54707379:C:G	F165L	0.801
11:54707404:T:C	F174L	0.768
11:54707406:C:A	F174L	0.768
11:54707406:C:G	F174L	0.768
11:54706969:T:C	F29L	0.638
11:54706971:T:A	F29L	0.638
11:54706971:T:G	F29L	0.638
11:54707182:T:C	F100L	0.637
11:54707184:T:A	F100L	0.637
11:54707184:T:G	F100L	0.637
11:54707158:T:C	F92L	0.629
11:54707160:C:A	F92L	0.629
11:54707160:C:G	F92L	0.629
11:54707626:T:C	F248L	0.578
11:54707628:T:A	F248L	0.578
11:54707628:T:G	F248L	0.578

dbSNP variants (sampled 300 via entrez): RS1001309389 (11:54706584 G>A,T), RS1002987923 (11:54705747 C>T), RS1003103442 (11:54705875 G>T), RS1003661504 (11:54708136 G>A,C), RS1003755882 (11:54705126 T>G), RS1004398538 (11:54705761 GA>G), RS1005070870 (11:54705913 T>A), RS1005537366 (11:54708270 C>A,T), RS1005816024 (11:54705316 C>G), RS1006285561 (11:54707642 T>C), RS1007894879 (11:54706149 T>A), RS1008299202 (11:54706378 G>A), RS1009860996 (11:54706577 C>G,T), RS1010182939 (11:54706386 C>T), RS1011809390 (11:54705630 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST000817_52	Height	3.000000e-08
GCST002783_54	Body mass index	3.000000e-07
GCST005580_48	Intraocular pressure	1.000000e-12
GCST005984_54	Glomerular filtration rate	3.000000e-08
GCST005985_33	Creatinine levels	2.000000e-08
GCST006947_8	Feeling fed-up	5.000000e-10
GCST007928_84	Medication use (diuretics)	2.000000e-08
GCST008058_8	Estimated glomerular filtration rate	7.000000e-10
GCST008060_15	Estimated glomerular filtration rate	7.000000e-07
GCST008075_200	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	7.000000e-06
GCST008075_63	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	7.000000e-11
GCST008084_173	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	1.000000e-07
GCST008084_20	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	6.000000e-13
GCST008085_94	HDL cholesterol levels in current drinkers	3.000000e-08
GCST008830_3	Neurofibrillary tangles	8.000000e-06
GCST010242_255	HDL cholesterol levels	1.000000e-09
GCST011108_5	Colorectal cancer x fine particulate matter exposure levels interaction	1.000000e-10

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004695	intraocular pressure measurement
EFO:0009588	feeling “fed-up” measurement
EFO:0009928	Diuretic use measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004329	alcohol drinking
EFO:0006797	neurofibrillary tangles measurement
EFO:0008255	particulate matter air pollution measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
bisphenol S	increases methylation	1
Benzo(a)pyrene	increases mutagenesis	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.