OR4C11

Summary

OR4C11 (olfactory receptor family 4 subfamily C member 11, HGNC:15167) is a protein-coding gene on chromosome 11q11, encoding Olfactory receptor 4C11 (Q6IEV9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219429 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 74 total
• MANE Select transcript: NM_001004700

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15167
Approved symbol	OR4C11
Name	olfactory receptor family 4 subfamily C member 11
Location	11q11
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000172188
Ensembl biotype	protein_coding
Entrez	219429

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641580

RefSeq mRNA: 1 — MANE Select: NM_001004700 NM_001004700

CCDS: CCDS31503

Canonical transcript exons

ENST00000641580 — 4 exons

Exon	Start	End
ENSE00003811522	55607287	55607645
ENSE00003812012	55606522	55606679
ENSE00003812399	55602360	55604417
ENSE00003812773	55605126	55605287

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.01	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.20	gold quality
urinary bladder	UBERON:0001255	28.47	gold quality
liver	UBERON:0002107	28.28	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.15	gold quality
monocyte	CL:0000576	27.10	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.90	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.22	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.96	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.22	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
frontal cortex	UBERON:0001870	24.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.12

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4c11c	ENSMUSG00000057447
mus_musculus	Or4c11b	ENSMUSG00000059023
mus_musculus	Or4c11	ENSMUSG00000062757
rattus_norvegicus	Or4c11	ENSRNOG00000063322

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 4C11 — Q6IEV9 (reviewed: Q6IEV9)

Alternative names: Olfactory receptor OR11-136

All UniProt accessions (2): A0A126GVN6, Q6IEV9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004700* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IEV9-F1	90.06	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, CAMPS_COLON_CANCER_COPY_NUMBER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, chr11q11, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

216 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4C11	ZFP14	Q9HCL3	399
OR4C11	FAM234B	A2RU67	393
OR4C11	TRIM48	Q8IWZ4	377
OR4C11	TRIM51	Q9BSJ1	368
OR4C11	HSDL1	Q3SXM5	359
OR4C11	ZNF41	P51814	349
OR4C11	TMTC3	Q6ZXV5	348
OR4C11	SPPL2C	Q8IUH8	305
OR4C11	LILRB5	O75023	279
OR4C11	CAPN7	Q9Y6W3	275
OR4C11	UGT2B17	O75795	269
OR4C11	ZNF737	O75373	264
OR4C11	HPDL	Q96IR7	248
OR4C11	ANKS1B	Q7Z6G8	247
OR4C11	APOBEC3B	Q9UH17	230

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60878, Q60881, Q6IEV9, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD1, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGM8, Q8NGN0, Q8NGN8, Q8NGP0, Q8NH05, Q8NH37, Q8NH42

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

74 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	4
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

323 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55604299:CA:C	donor_gain	0.8400
11:55604212:T:TA	donor_gain	0.7900
11:55604291:A:AC	donor_gain	0.7800
11:55604356:A:AC	donor_gain	0.7100
11:55604357:C:CC	donor_gain	0.7100
11:55604310:G:GA	donor_gain	0.6700
11:55604355:CA:C	donor_gain	0.6400
11:55604298:A:AC	donor_gain	0.6200
11:55604299:C:CC	donor_gain	0.6200
11:55604295:CAAA:C	donor_gain	0.5900
11:55604294:A:AC	donor_gain	0.5800
11:55604295:C:CC	donor_gain	0.5800
11:55603608:A:C	acceptor_gain	0.5600
11:55603610:A:C	acceptor_gain	0.5600
11:55603834:C:CC	acceptor_gain	0.5500
11:55604167:AGAAT:A	acceptor_gain	0.5500
11:55604204:A:C	donor_gain	0.5300
11:55603479:A:C	donor_gain	0.5200
11:55603706:A:T	acceptor_gain	0.5200
11:55604321:T:TA	donor_gain	0.5200
11:55603606:A:C	acceptor_gain	0.5100
11:55603620:A:C	acceptor_gain	0.5100
11:55603604:G:C	acceptor_gain	0.5000
11:55603389:A:AC	donor_gain	0.4900
11:55603390:C:CC	donor_gain	0.4900
11:55603502:T:TA	donor_gain	0.4800
11:55603704:TCA:T	acceptor_gain	0.4800
11:55604199:A:AC	donor_gain	0.4800
11:55604297:A:T	donor_gain	0.4800
11:55603411:C:CC	acceptor_gain	0.4700

AlphaMissense

2049 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55603876:G:C	F166L	0.876
11:55603876:G:T	F166L	0.876
11:55603878:A:G	F166L	0.876
11:55603750:A:C	S208R	0.874
11:55603750:A:T	S208R	0.874
11:55603752:T:G	S208R	0.874
11:55604344:G:C	F10L	0.858
11:55604344:G:T	F10L	0.858
11:55604346:A:G	F10L	0.858
11:55604074:A:C	F100L	0.801
11:55604074:A:T	F100L	0.801
11:55604076:A:G	F100L	0.801
11:55603627:A:C	F249L	0.784
11:55603627:A:T	F249L	0.784
11:55603629:A:G	F249L	0.784
11:55604166:A:G	C70R	0.782
11:55603935:A:G	W147R	0.778
11:55603935:A:T	W147R	0.778
11:55604059:A:C	F105L	0.746
11:55604059:A:T	F105L	0.746
11:55604061:A:G	F105L	0.746
11:55603753:A:C	S207R	0.744
11:55603753:A:T	S207R	0.744
11:55603755:T:G	S207R	0.744
11:55603612:G:C	F254L	0.729
11:55603612:G:T	F254L	0.729
11:55603614:A:G	F254L	0.729
11:55604147:G:T	A76D	0.721
11:55604026:C:A	M116I	0.720
11:55604026:C:G	M116I	0.720

dbSNP variants (sampled 300 via entrez): RS1000940599 (11:55602422 C>T), RS1001289362 (11:55602780 A>G), RS1001894142 (11:55605212 A>C), RS1002346667 (11:55604622 G>C), RS1005124546 (11:55606977 A>C), RS1005861055 (11:55608813 T>G), RS1006745101 (11:55603508 T>C), RS1006798859 (11:55603001 G>T), RS1011690000 (11:55607795 A>G), RS1012169024 (11:55602293 AAAT>A), RS1013174263 (11:55604570 C>A,T), RS1014597533 (11:55609007 CCCT>C), RS1014630021 (11:55608307 A>G), RS1014664210 (11:55607863 C>A,T), RS1017832279 (11:55605752 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST007094_101	Diastolic blood pressure	4.000000e-06
GCST007095_40	Systolic blood pressure	4.000000e-07
GCST007095_41	Systolic blood pressure	1.000000e-06
GCST007099_2	Systolic blood pressure	5.000000e-08

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure
EFO:0006335	systolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.