OR4C13

Summary

OR4C13 (olfactory receptor family 4 subfamily C member 13, HGNC:15169) is a protein-coding gene on chromosome 11p11.12, encoding Olfactory receptor 4C13 (Q8NGP0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 283092 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 72 total
• MANE Select transcript: NM_001001955

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15169
Approved symbol	OR4C13
Name	olfactory receptor family 4 subfamily C member 13
Location	11p11.12
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000258817
Ensembl biotype	protein_coding
Entrez	283092

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000555099

RefSeq mRNA: 1 — MANE Select: NM_001001955 NM_001001955

CCDS: CCDS31495

Canonical transcript exons

ENST00000555099 — 1 exons

Exon	Start	End
ENSE00002468127	49952391	49953419

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 91.70.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.70	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
monocyte	CL:0000576	31.95	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
leukocyte	CL:0000738	31.56	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.25	silver quality
liver	UBERON:0002107	28.31	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.88	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.25	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
cortex of kidney	UBERON:0001225	25.82	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.04	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.14

Regulation

Is transcription factor: no

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4c10b	ENSMUSG00000049057
mus_musculus	Or4c10	ENSMUSG00000049149
mus_musculus	Or4c106	ENSMUSG00000061798
mus_musculus	Or4c105	ENSMUSG00000064084
rattus_norvegicus	Or4c10b	ENSRNOG00000071986
rattus_norvegicus	Olr655	ENSRNOG00000072336
rattus_norvegicus	Or4c10	ENSRNOG00000081416
rattus_norvegicus	Or4c105	ENSRNOG00000084716
rattus_norvegicus	Or4c105b	ENSRNOG00000089765

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4C13 — Q8NGP0 (reviewed: Q8NGP0)

Alternative names: Olfactory receptor OR11-260

All UniProt accessions (1): Q8NGP0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001955* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGP0-F1	88.34	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (2): 6, 87

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

106 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4C13	TAS2R16	Q9NYV7	445
OR4C13	OR9K2	Q8NGE7	377
OR4C13	TAAR5	O14804	376
OR4C13	TLDC2	A0PJX2	358
OR4C13	TRPM5	Q9NZQ8	337
OR4C13	TRHR	P34981	307
OR4C13	OR8G5	Q8NG78	304
OR4C13	OR5M3	Q8NGP4	303
OR4C13	ADRA2C	P18825	291
OR4C13	CNGB1	Q14028	273
OR4C13	OR51S1	Q8NGJ8	250
OR4C13	CNGA3	Q16281	249
OR4C13	TAS1R1	Q7RTX1	240
OR4C13	FREM3	P0C091	234
OR4C13	OR56A5	P0C7T3	232

IntAct

0 interactions, top by confidence:

BioGRID (1): OR4C13 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60878, Q60881, Q6IEV9, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD1, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGM8, Q8NGN0, Q8NGN8, Q8NGP0, Q8NH05, Q8NH37, Q8NH42

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	69
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

140 predictions. Top by Δscore:

Variant	Effect	Δscore
11:49953060:T:TA	acceptor_gain	0.8200
11:49952521:C:G	acceptor_gain	0.7600
11:49952520:A:AG	acceptor_gain	0.6800
11:49952523:T:G	acceptor_gain	0.6100
11:49953180:T:G	acceptor_gain	0.5800
11:49952703:G:GT	donor_gain	0.5300
11:49952512:T:TA	acceptor_gain	0.5200
11:49952604:T:TA	acceptor_gain	0.5200
11:49953283:G:GC	acceptor_gain	0.5200
11:49953116:C:T	donor_gain	0.4800
11:49952522:A:AG	acceptor_gain	0.4600
11:49952517:T:G	acceptor_gain	0.4400
11:49952527:C:CA	acceptor_gain	0.4400
11:49952743:TGTTG:T	donor_gain	0.4400
11:49953271:A:AG	acceptor_gain	0.4400
11:49953279:CCTTG:C	acceptor_gain	0.4400
11:49952391:CAG:C	donor_loss	0.4200
11:49952392:AGGTA:A	donor_loss	0.4200
11:49952393:GG:G	donor_loss	0.4200
11:49952744:GTTGA:G	donor_gain	0.4200
11:49952852:G:GT	donor_gain	0.4200
11:49952655:A:G	acceptor_gain	0.4000
11:49952834:G:GG	donor_gain	0.4000
11:49953152:G:GG	donor_gain	0.3900
11:49952623:T:A	acceptor_gain	0.3800
11:49952753:A:AG	donor_gain	0.3800
11:49952833:T:TG	donor_gain	0.3800
11:49953151:A:AG	donor_gain	0.3800
11:49953278:A:AG	acceptor_gain	0.3800
11:49952395:T:G	donor_loss	0.3700

AlphaMissense

2037 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:49952450:T:C	F10L	0.811
11:49952452:T:A	F10L	0.811
11:49952452:T:G	F10L	0.811
11:49952918:T:C	F166L	0.772
11:49952920:C:A	F166L	0.772
11:49952920:C:G	F166L	0.772
11:49952945:T:C	F175L	0.706
11:49952947:T:A	F175L	0.706
11:49952947:T:G	F175L	0.706
11:49952720:T:C	F100L	0.691
11:49952722:T:A	F100L	0.691
11:49952722:T:G	F100L	0.691
11:49952507:T:C	F29L	0.620
11:49952509:T:A	F29L	0.620
11:49952509:T:G	F29L	0.620

dbSNP variants (sampled 300 via entrez): RS11040677 (11:49953616 C>T), RS11040678 (11:49953685 G>A), RS111385765 (11:49952155 G>A,C,T), RS111612557 (11:49952992 C>A,T), RS112669721 (11:49951032 C>A,G,T), RS11289877 (11:49953457 TG>T), RS113645272 (11:49952765 G>A), RS113725256 (11:49953309 T>C), RS114496660 (11:49951173 C>A,T), RS115341111 (11:49951799 T>C), RS1156273135 (11:49952555 G>A), RS1156363206 (11:49951868 T>C), RS1156659432 (11:49950399 TA>T), RS1158264392 (11:49952972 A>C,G), RS1158286422 (11:49950813 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST005580_66	Intraocular pressure	6.000000e-12
GCST010241_195	Apolipoprotein A1 levels	5.000000e-26
GCST010242_112	HDL cholesterol levels	2.000000e-08
GCST010242_529	HDL cholesterol levels	1.000000e-48
GCST010244_408	Triglyceride levels	4.000000e-10
GCST012020_207	Serum metabolite levels	5.000000e-37

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Atrazine	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.