OR4C15

Summary

OR4C15 (olfactory receptor family 4 subfamily C member 15, HGNC:15171) is a protein-coding gene on chromosome 11q11, encoding Olfactory receptor 4C15 (Q8NGM1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81309 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 103 total
• MANE Select transcript: NM_001001920

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15171
Approved symbol	OR4C15
Name	olfactory receptor family 4 subfamily C member 15
Location	11q11
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000181939
Ensembl biotype	protein_coding
Entrez	81309

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000314644, ENST00000642128

RefSeq mRNA: 1 — MANE Select: NM_001001920 NM_001001920

CCDS: CCDS31501

Canonical transcript exons

ENST00000642128 — 1 exons

Exon	Start	End
ENSE00003814065	55554469	55555419

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 55.66.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	55.66	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	28.31	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.86	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	27.00	gold quality
monocyte	CL:0000576	26.94	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.35	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
calcaneal tendon	UBERON:0003701	25.05	gold quality
muscle of leg	UBERON:0001383	25.00	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
cortex of kidney	UBERON:0001225	24.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

42 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4c107	ENSMUSG00000048226
mus_musculus	Or4c124	ENSMUSG00000075092
mus_musculus	Or4c15b	ENSMUSG00000075095
mus_musculus	Or4c121	ENSMUSG00000075097
mus_musculus	Or4c119	ENSMUSG00000075099
mus_musculus	Or4c118	ENSMUSG00000075100
mus_musculus	Or4c117	ENSMUSG00000075101
mus_musculus	Or4c116	ENSMUSG00000075102
mus_musculus	Or4c114	ENSMUSG00000075104
mus_musculus	Or4c113	ENSMUSG00000075105
mus_musculus	Or4c111	ENSMUSG00000075107
mus_musculus	Or4c109	ENSMUSG00000075110
mus_musculus	Or4c108	ENSMUSG00000075111
mus_musculus	Or4c15	ENSMUSG00000075112
mus_musculus	Or4c122	ENSMUSG00000099486
mus_musculus	Or4c110	ENSMUSG00000100016
mus_musculus	Or4c112	ENSMUSG00000101391
mus_musculus	Or4c115	ENSMUSG00000101480
mus_musculus	Or4c120	ENSMUSG00000101918
rattus_norvegicus		ENSRNOG00000071625
rattus_norvegicus		ENSRNOG00000073136
rattus_norvegicus		ENSRNOG00000073403
rattus_norvegicus	Or4c109b	ENSRNOG00000073832
rattus_norvegicus	Or4c112	ENSRNOG00000074869
rattus_norvegicus	Olr673	ENSRNOG00000075811
rattus_norvegicus	Or4c116	ENSRNOG00000077622
rattus_norvegicus	Or4c114	ENSRNOG00000079233
rattus_norvegicus	Or4c124b	ENSRNOG00000079562
rattus_norvegicus	Or4c117	ENSRNOG00000080961
rattus_norvegicus	Or4c112b	ENSRNOG00000083214
rattus_norvegicus	Or4c120	ENSRNOG00000083405
rattus_norvegicus	Or4c122	ENSRNOG00000084131
rattus_norvegicus	Or4c115	ENSRNOG00000086079
rattus_norvegicus	Or4c109	ENSRNOG00000086173
rattus_norvegicus	Or4c117b	ENSRNOG00000086632
rattus_norvegicus	Or4c108b	ENSRNOG00000087334
rattus_norvegicus	Or4c110	ENSRNOG00000088028
rattus_norvegicus	Or4c15	ENSRNOG00000088600
rattus_norvegicus	Or4c107	ENSRNOG00000088619
rattus_norvegicus	Or4c111	ENSRNOG00000089728
rattus_norvegicus	Or4c15b	ENSRNOG00000089791
rattus_norvegicus	Or4c121	ENSRNOG00000090210

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4C15 — Q8NGM1 (reviewed: Q8NGM1)

Alternative names: Olfactory receptor OR11-127, Olfactory receptor OR11-134

All UniProt accessions (2): Q8NGM1, A0A2C9F2M4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001001920* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGM1-F1	90.04	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 96–188

Glycosylation sites (1): 3

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, RAY_TUMORIGENESIS_BY_ERBB2_CDC25A_UP, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, chr11q11, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

222 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4C15	TRIM48	Q8IWZ4	395
OR4C15	TRIM51	Q9BSJ1	371
OR4C15	WDR17	Q8IZU2	359
OR4C15	FRMD1	Q8N878	352
OR4C15	KIF25	Q9UIL4	351
OR4C15	PRB4	P02813	323
OR4C15	CSMD3	Q7Z407	290
OR4C15	RALGAPA1	Q6GYQ0	289
OR4C15	ZNF737	O75373	272
OR4C15	PKHD1L1	Q86WI1	271
OR4C15	CD163L1	Q9NR16	270
OR4C15	SLC2A13	Q96QE2	247
OR4C15	CDH12	P55289	223
OR4C15	COL22A1	Q8NFW1	222
OR4C15	LIMD1	Q9UGP4	220
OR4C15	NAV3	Q8IVL0	220

IntAct

0 interactions, top by confidence:

BioGRID (1): OR4C15 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

103 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	97
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

231 predictions. Top by Δscore:

Variant	Effect	Δscore
11:55554535:G:GT	donor_gain	0.9900
11:55554536:A:T	donor_gain	0.9900
11:55554879:G:GT	donor_gain	0.9800
11:55554483:C:G	donor_gain	0.9100
11:55554482:GCTTT:G	donor_gain	0.9000
11:55554794:TGG:T	donor_gain	0.8400
11:55554541:G:GG	donor_gain	0.8200
11:55554831:T:G	donor_gain	0.8100
11:55554350:G:GT	donor_gain	0.8000
11:55554540:A:AG	donor_gain	0.7900
11:55554393:G:GT	donor_gain	0.7500
11:55554491:C:G	donor_gain	0.7400
11:55554530:TTC:T	donor_gain	0.6700
11:55554528:T:G	donor_gain	0.6600
11:55554335:A:AG	donor_gain	0.6500
11:55554530:T:G	donor_gain	0.6500
11:55554599:T:TA	donor_gain	0.6300
11:55554600:A:AA	donor_gain	0.6300
11:55554489:AACTG:A	donor_gain	0.6100
11:55554490:ACTGA:A	donor_gain	0.6100
11:55554543:ATT:A	donor_gain	0.6100
11:55554544:TTT:T	donor_gain	0.6100
11:55554325:G:GT	donor_gain	0.6000
11:55554905:T:TA	donor_gain	0.6000
11:55554906:A:AA	donor_gain	0.6000
11:55554959:A:AG	acceptor_gain	0.6000
11:55554960:G:GG	acceptor_gain	0.6000
11:55555073:G:GG	donor_gain	0.5800
11:55554487:G:GG	donor_gain	0.5700
11:55554796:G:GT	donor_gain	0.5700

AlphaMissense

2106 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:55554496:T:C	F10L	0.925
11:55554498:T:A	F10L	0.925
11:55554498:T:G	F10L	0.925
11:55554994:T:C	F176L	0.840
11:55554996:T:A	F176L	0.840
11:55554996:T:G	F176L	0.840
11:55554967:T:C	F167L	0.838
11:55554969:T:A	F167L	0.838
11:55554969:T:G	F167L	0.838
11:55554910:T:A	W148R	0.803
11:55554910:T:C	W148R	0.803
11:55554819:G:A	M117I	0.796
11:55554819:G:C	M117I	0.796
11:55554819:G:T	M117I	0.796
11:55554830:G:C	R121P	0.788
11:55555072:A:C	S202R	0.786
11:55555074:T:A	S202R	0.786
11:55555074:T:G	S202R	0.786
11:55554497:T:G	F10C	0.773
11:55554828:T:A	D120E	0.770
11:55554828:T:G	D120E	0.770
11:55554497:T:C	F10S	0.766
11:55554769:T:C	F101L	0.756
11:55554771:T:A	F101L	0.756
11:55554771:T:G	F101L	0.756
11:55554588:C:A	N40K	0.731
11:55554588:C:G	N40K	0.731
11:55555000:T:A	C178S	0.717
11:55555001:G:C	C178S	0.717
11:55554827:A:C	D120A	0.714

dbSNP variants (sampled 300 via entrez): RS1001146427 (11:55553463 T>A,C), RS1005020929 (11:55552669 C>A,T), RS1005378363 (11:55552974 T>C), RS1005842490 (11:55553148 G>T), RS1007773859 (11:55554075 A>C), RS1008820344 (11:55555563 A>G,T), RS1012628541 (11:55552535 GTC>G), RS1013661688 (11:55554122 A>C,G), RS1016690555 (11:55552985 A>C,G), RS1017684499 (11:55554615 C>A,G,T), RS1019741496 (11:55555569 A>C,T), RS1021728160 (11:55552558 A>T), RS1024020864 (11:55553232 G>A,T), RS1024608773 (11:55554123 T>A), RS1025327531 (11:55554085 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002783_55	Body mass index	3.000000e-06
GCST005580_74	Intraocular pressure	1.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004695	intraocular pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1
Sodium Selenite	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.