OR4C3

Summary

OR4C3 (olfactory receptor family 4 subfamily C member 3, HGNC:14697) is a protein-coding gene on chromosome 11p11.2, encoding Olfactory receptor 4C3 (Q8NH37). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 256144 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 2 total
• MANE Select transcript: NM_001004702

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14697
Approved symbol	OR4C3
Name	olfactory receptor family 4 subfamily C member 3
Location	11p11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176547
Ensembl biotype	protein_coding
Entrez	256144

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000319856

RefSeq mRNA: 1 — MANE Select: NM_001004702 NM_001004702

CCDS: CCDS31489

Canonical transcript exons

ENST00000319856 — 1 exons

Exon	Start	End
ENSE00001260295	48324920	48325955

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 37.20.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	36.74	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
monocyte	CL:0000576	31.03	silver quality
leukocyte	CL:0000738	30.72	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.58	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
cortex of kidney	UBERON:0001225	26.42	silver quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.06	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
pancreas	UBERON:0001264	24.01	gold quality
frontal cortex	UBERON:0001870	23.91	gold quality
gastrocnemius	UBERON:0001388	23.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HNF4A

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4c3	ENSMUSG00000075069
rattus_norvegicus	Or4c3	ENSRNOG00000081832

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4C3 — Q8NH37 (reviewed: Q8NH37)

Alternative names: Olfactory receptor OR11-98

All UniProt accessions (2): A0A126GW65, Q8NH37

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004702* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH37-F1	89.61	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–187

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 25 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, KAECH_NAIVE_VS_DAY15_EFF_CD8_TCELL_UP, ZNF274_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

342 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4C3	ZNF717	Q9BY31	577
OR4C3	SPATA17	Q96L03	447
OR4C3	UBTFL1	P0CB47	400
OR4C3	ZNF781	Q8N8C0	380
OR4C3	SAXO1	Q8IYX7	379
OR4C3	CFAP65	Q6ZU64	374
OR4C3	FRG2C	A6NGY1	371
OR4C3	POM121L12	Q8N7R1	370
OR4C3	GPR107	Q5VW38	364
OR4C3	ARHGEF33	A8MVX0	364
OR4C3	GAL3ST3	Q96A11	359
OR4C3	PLEKHG4B	Q96PX9	356
OR4C3	LRFN5	Q96NI6	355
OR4C3	RCAN1	P53805	353
OR4C3	LYAR	Q9NX58	344

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60878, Q60881, Q6IEV9, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGD0, Q8NGD1, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGL6, Q8NGL7, Q8NGL9, Q8NGM1, Q8NGM8, Q8NGN0, Q8NGN8, Q8NGP0, Q8NH05, Q8NH37, Q8NH42

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

2 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

151 predictions. Top by Δscore:

Variant	Effect	Δscore
11:48325245:T:G	acceptor_gain	0.8600
11:48325244:AT:A	acceptor_gain	0.8500
11:48325245:T:TA	acceptor_gain	0.8300
11:48325244:ATG:A	acceptor_gain	0.7700
11:48325244:A:AG	acceptor_gain	0.7500
11:48325246:G:A	acceptor_gain	0.7100
11:48325079:GAG:G	donor_gain	0.6500
11:48325569:T:A	acceptor_gain	0.6400
11:48325077:CAGAG:C	donor_loss	0.6300
11:48325078:AGAG:A	donor_loss	0.6300
11:48325079:GAGGT:G	donor_loss	0.6300
11:48325080:AGGT:A	donor_loss	0.6300
11:48325081:GGT:G	donor_loss	0.6300
11:48325082:GT:G	donor_loss	0.6300
11:48325083:T:A	donor_loss	0.6300
11:48325656:T:A	acceptor_gain	0.5600
11:48325608:T:A	acceptor_gain	0.5100
11:48325082:G:GG	donor_gain	0.4800
11:48325690:G:GC	acceptor_gain	0.4700
11:48325653:T:G	acceptor_gain	0.4600
11:48325079:G:GT	donor_gain	0.4200
11:48325876:T:G	acceptor_gain	0.4200
11:48325568:CTGGA:C	acceptor_gain	0.4000
11:48325254:A:G	acceptor_gain	0.3900
11:48325689:TGAGG:T	acceptor_gain	0.3900
11:48325253:A:AG	acceptor_gain	0.3800
11:48325084:A:C	donor_loss	0.3600
11:48325652:ATGCT:A	acceptor_gain	0.3600
11:48325652:AT:A	acceptor_gain	0.3500
11:48325817:GACAA:G	acceptor_gain	0.3400

AlphaMissense

1972 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:48325544:T:C	F175L	0.900
11:48325546:T:A	F175L	0.900
11:48325546:T:G	F175L	0.900
11:48325517:T:C	F166L	0.880
11:48325519:C:A	F166L	0.880
11:48325519:C:G	F166L	0.880
11:48325049:T:C	F10L	0.863
11:48325051:T:A	F10L	0.863
11:48325051:T:G	F10L	0.863
11:48325319:T:C	F100L	0.784
11:48325321:T:A	F100L	0.784
11:48325321:T:G	F100L	0.784
11:48325106:T:C	F29L	0.740
11:48325108:T:A	F29L	0.740
11:48325108:T:G	F29L	0.740
11:48325766:T:C	F249L	0.697
11:48325768:T:A	F249L	0.697
11:48325768:T:G	F249L	0.697
11:48325763:T:C	F248L	0.680
11:48325765:C:A	F248L	0.680
11:48325765:C:G	F248L	0.680
11:48325622:A:C	S201R	0.654
11:48325624:T:A	S201R	0.654
11:48325624:T:G	S201R	0.654
11:48325460:T:A	W147R	0.643
11:48325460:T:C	W147R	0.643
11:48325781:T:C	F254L	0.642
11:48325783:T:A	F254L	0.642
11:48325783:T:G	F254L	0.642
11:48325646:T:C	F209L	0.638

dbSNP variants (sampled 300 via entrez): RS1000777353 (11:48323287 T>C), RS1003292417 (11:48324823 C>T), RS1003585872 (11:48324574 G>A), RS1004143127 (11:48326225 A>G), RS1005137673 (11:48325132 T>C,G), RS1005189833 (11:48324877 G>A), RS1006138825 (11:48324016 C>A,T), RS1006189632 (11:48323789 G>C), RS1008398761 (11:48326274 G>A), RS1013868009 (11:48323321 G>C), RS1015776663 (11:48326073 T>A,C,G), RS1016564362 (11:48325144 G>C,T), RS1016784992 (11:48324888 G>A,C,T), RS1016835917 (11:48324622 A>C), RS1017567801 (11:48324025 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010774_29	Essential hypertension (time to event)	3.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004918	age at diagnosis

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Plant Extracts	decreases expression, affects cotreatment	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.