OR4D11

Summary

OR4D11 (olfactory receptor family 4 subfamily D member 11, HGNC:15174) is a protein-coding gene on chromosome 11q12.1, encoding Olfactory receptor 4D11 (Q8NGI4). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 219986 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 55 total
• MANE Select transcript: NM_001004706

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15174
Approved symbol	OR4D11
Name	olfactory receptor family 4 subfamily D member 11
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176200
Ensembl biotype	protein_coding
Entrez	219986

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000313253

RefSeq mRNA: 1 — MANE Select: NM_001004706 NM_001004706

CCDS: CCDS31563

Canonical transcript exons

ENST00000313253 — 1 exons

Exon	Start	End
ENSE00001270798	59503576	59504511

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
urinary bladder	UBERON:0001255	29.09	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.33	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.30	gold quality
leukocyte	CL:0000738	26.07	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
monocyte	CL:0000576	25.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.81	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.14	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
frontal cortex	UBERON:0001870	23.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4d11	ENSMUSG00000067529
rattus_norvegicus	Or4d11	ENSRNOG00000090827

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 4D11 — Q8NGI4 (reviewed: Q8NGI4)

All UniProt accessions (2): A0A126GVQ9, Q8NGI4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004706* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGI4-F1	86.74	0.43

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11q12

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

200 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4D11	MTG2	Q9H4K7	397
OR4D11	PSG6	Q00889	323
OR4D11	PSG3	Q16557	316
OR4D11	SDR9C7	Q8NEX9	307
OR4D11	CEACAM4	O75871	305
OR4D11	SLC25A14	O95258	302
OR4D11	CEACAM7	Q14002	299
OR4D11	CEACAM3	P40198	295
OR4D11	PSG4	Q00888	292
OR4D11	PSG9	Q00887	290
OR4D11	PSG8	Q9UQ74	288
OR4D11	A0A096LNM5	A0A096LNM5	284
OR4D11	PI4KA	P42356	282
OR4D11	PSG1	P11462	272
OR4D11	PSG2	P11465	270

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

55 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

310 predictions. Top by Δscore:

Variant	Effect	Δscore
11:59504420:T:A	acceptor_gain	0.8800
11:59504417:T:TA	acceptor_gain	0.8000
11:59504343:T:G	acceptor_gain	0.7200
11:59504232:A:AG	acceptor_gain	0.7000
11:59504233:G:GG	acceptor_gain	0.7000
11:59504429:T:A	acceptor_gain	0.7000
11:59504437:ACTCT:A	acceptor_gain	0.6800
11:59504264:G:GT	donor_gain	0.6500
11:59504364:T:A	acceptor_gain	0.6500
11:59504377:GA:G	acceptor_gain	0.6500
11:59504353:C:CA	acceptor_gain	0.6400
11:59504278:A:T	donor_gain	0.6300
11:59504377:GAAAA:G	acceptor_gain	0.6300
11:59504435:A:AG	acceptor_gain	0.6300
11:59504374:ACAG:A	acceptor_loss	0.6200
11:59504376:A:AC	acceptor_loss	0.6200
11:59504376:A:AG	acceptor_gain	0.6200
11:59504377:G:GG	acceptor_gain	0.6200
11:59504437:A:AG	acceptor_gain	0.6200
11:59504230:A:AG	acceptor_gain	0.6100
11:59504216:T:A	acceptor_gain	0.6000
11:59504254:TCTC:T	donor_gain	0.6000
11:59504274:G:GT	donor_gain	0.6000
11:59504318:C:G	donor_gain	0.6000
11:59504377:GAA:G	acceptor_gain	0.6000
11:59504436:C:G	acceptor_gain	0.6000
11:59504441:T:A	acceptor_gain	0.6000
11:59504317:A:AG	donor_gain	0.5900
11:59504248:C:G	donor_gain	0.5800
11:59504362:ACT:A	acceptor_gain	0.5700

AlphaMissense

2022 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:59504077:T:C	F168L	0.828
11:59504079:C:A	F168L	0.828
11:59504079:C:G	F168L	0.828
11:59503609:T:C	F12L	0.798
11:59503611:T:A	F12L	0.798
11:59503611:T:G	F12L	0.798
11:59504104:T:C	F177L	0.775
11:59504106:C:A	F177L	0.775
11:59504106:C:G	F177L	0.775
11:59504359:T:C	F262L	0.762
11:59504361:C:A	F262L	0.762
11:59504361:C:G	F262L	0.762
11:59504326:T:C	F251L	0.683
11:59504328:T:A	F251L	0.683
11:59504328:T:G	F251L	0.683
11:59504206:T:C	F211L	0.667
11:59504208:T:A	F211L	0.667
11:59504208:T:G	F211L	0.667
11:59503792:T:C	F73L	0.663
11:59503794:C:A	F73L	0.663
11:59503794:C:G	F73L	0.663
11:59503885:T:C	F104L	0.620
11:59503887:C:A	F104L	0.620
11:59503887:C:G	F104L	0.620
11:59503820:T:C	L82S	0.619
11:59503657:T:C	F28L	0.594
11:59503659:T:A	F28L	0.594
11:59503659:T:G	F28L	0.594
11:59503820:T:G	L82W	0.589
11:59503879:T:C	F102L	0.588

dbSNP variants (sampled 300 via entrez): RS1000845795 (11:59504946 A>C), RS1001638713 (11:59504435 A>G), RS1002639837 (11:59502811 G>A), RS1003341211 (11:59502611 A>G), RS1003849849 (11:59503386 T>A,C), RS1005839438 (11:59502534 G>A), RS1007474218 (11:59501916 A>T), RS1008879552 (11:59504648 A>G), RS1010335320 (11:59504900 A>G), RS1010742095 (11:59503289 T>G), RS1010847853 (11:59504646 A>G), RS1013040165 (11:59502290 A>T), RS1013316966 (11:59502568 G>A), RS1015020219 (11:59504665 A>C,G), RS1015368603 (11:59503388 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Particulate Matter	increases abundance, increases expression, decreases expression	2
Resveratrol	affects cotreatment, decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	decreases expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.