OR4F17

Summary

OR4F17 (olfactory receptor family 4 subfamily F member 17, HGNC:15381) is a protein-coding gene on chromosome 19p13.3, encoding Olfactory receptor 4F17 (Q8NGA8). Odorant receptor. It is a selective cancer dependency (DepMap: 80.0% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81099 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• Cancer dependency (DepMap): dependent in 80.0% of screened cell lines
• MANE Select transcript: NM_001005240

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15381
Approved symbol	OR4F17
Name	olfactory receptor family 4 subfamily F member 17
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176695
Ensembl biotype	protein_coding
Entrez	81099

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000318050, ENST00000585993, ENST00000618231, ENST00000641591

RefSeq mRNA: 2 — MANE Select: NM_001005240 NM_001005240, NM_001429985

CCDS: CCDS32854

Canonical transcript exons

ENST00000585993 — 3 exons

Exon	Start	End
ENSE00002825729	107473	107555
ENSE00002973945	110625	113156
ENSE00003819007	107104	107157

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 98.36.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	98.36	gold quality
bone marrow cell	CL:0002092	94.22	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.17	gold quality
sural nerve	UBERON:0015488	72.91	gold quality
tonsil	UBERON:0002372	72.36	gold quality
stromal cell of endometrium	CL:0002255	64.53	gold quality
skeletal muscle tissue	UBERON:0001134	64.34	gold quality
bone marrow	UBERON:0002371	63.68	gold quality
cortical plate	UBERON:0005343	63.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.96	gold quality
muscle tissue	UBERON:0002385	55.66	gold quality
urinary bladder	UBERON:0001255	51.26	gold quality
ganglionic eminence	UBERON:0004023	48.94	gold quality
uterine cervix	UBERON:0000002	48.25	gold quality
ventricular zone	UBERON:0003053	45.94	gold quality
liver	UBERON:0002107	45.44	gold quality
adrenal tissue	UBERON:0018303	42.71	gold quality
skin of abdomen	UBERON:0001416	41.77	gold quality
kidney	UBERON:0002113	40.30	gold quality
zone of skin	UBERON:0000014	39.81	gold quality
prefrontal cortex	UBERON:0000451	38.82	gold quality
primary visual cortex	UBERON:0002436	38.78	gold quality
mucosa of stomach	UBERON:0001199	38.28	silver quality
leukocyte	CL:0000738	38.25	silver quality
skin of leg	UBERON:0001511	37.67	gold quality
monocyte	CL:0000576	37.37	silver quality
ectocervix	UBERON:0012249	37.35	gold quality
blood	UBERON:0000178	36.48	gold quality
gall bladder	UBERON:0002110	36.04	gold quality
granulocyte	CL:0000094	35.23	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-7249	yes	73.44
E-ANND-3	yes	3.12
E-ENAD-27	no	113.42
E-MTAB-6379	no	58.16

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 80.0% of screened cell lines.

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4f4b	ENSMUSG00000061195
mus_musculus	Or4f4-ps1	ENSMUSG00000108891
mus_musculus	Or4f17	ENSMUSG00000108908
rattus_norvegicus	Or4f4b	ENSRNOG00000079002
rattus_norvegicus		ENSRNOG00000080423
rattus_norvegicus		ENSRNOG00000086124

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4F17 — Q8NGA8 (reviewed: Q8NGA8)

Alternative names: Olfactory receptor 4F11, Olfactory receptor 4F18, Olfactory receptor 4F19

All UniProt accessions (3): Q8NGA8, A0A126GWN0, A0A2U3U062

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005240, NP_001416914 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGA8-F1	89.21	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 90–182

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, chr19p13, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

104 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4F17	MBD3L4	A6NDZ8	610
OR4F17	GOLGA8CP	A6NN73	593
OR4F17	MBD3L3	A6NE82	507
OR4F17	MBD3L5	A6NJ08	475
OR4F17	CLEC18B	Q6UXF7	473
OR4F17	ZNF557	Q8N988	471
OR4F17	MIER2	Q8N344	447
OR4F17	PLEKHN1	Q494U1	447
OR4F17	FAM72B	Q86X60	435
OR4F17	NBPF15	Q8N660	417
OR4F17	SAMD11	Q96NU1	373
OR4F17	UGT2B17	O75795	370
OR4F17	MBD3L2	Q8NHZ7	348
OR4F17	UGT2B28	Q9BY64	321
OR4F17	GUCY1A2	P33402	313

IntAct

0 interactions, top by confidence:

BioGRID (2): OR4F17 (Negative Genetic), OR4F17 (Negative Genetic)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	7
Benign	6

Top pathogenic / likely-pathogenic (0)

SpliceAI

83 predictions. Top by Δscore:

Variant	Effect	Δscore
19:110620:TCAA:T	acceptor_loss	0.9900
19:110621:CAAG:C	acceptor_loss	0.9900
19:110622:AAGGT:A	acceptor_loss	0.9900
19:110623:A:G	acceptor_gain	0.9900
19:110623:AGGTA:A	acceptor_loss	0.9900
19:110622:A:AG	acceptor_gain	0.9800
19:110622:AAG:A	acceptor_gain	0.9800
19:110624:G:GG	acceptor_gain	0.9600
19:110624:GGTAA:G	acceptor_gain	0.9600
19:110621:CAAGG:C	acceptor_gain	0.9300
19:110624:GGTA:G	acceptor_gain	0.9300
19:110620:TCAAG:T	acceptor_gain	0.9200
19:110624:GGT:G	acceptor_gain	0.9200
19:110622:AAGG:A	acceptor_gain	0.9000
19:110623:AG:A	acceptor_gain	0.8700
19:110623:AGGT:A	acceptor_gain	0.8700
19:110624:GG:G	acceptor_gain	0.8700
19:110627:A:AG	acceptor_gain	0.8700
19:110624:G:T	acceptor_gain	0.7700
19:110619:TTCAA:T	acceptor_gain	0.7400
19:107551:TAAAG:T	donor_loss	0.7200
19:107552:AAAGG:A	donor_loss	0.7200
19:107553:AAG:A	donor_loss	0.7200
19:107554:AGG:A	donor_loss	0.7200
19:107555:G:GC	donor_loss	0.7200
19:107556:G:GA	donor_loss	0.7200
19:107557:T:A	donor_loss	0.7200
19:107531:TTTG:T	donor_gain	0.6800
19:107732:GACA:G	donor_gain	0.6300
19:107558:A:C	donor_loss	0.6200

AlphaMissense

2016 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:110691:T:C	F5L	0.962
19:110693:C:A	F5L	0.962
19:110693:C:G	F5L	0.962
19:111183:A:C	S169R	0.952
19:111185:T:A	S169R	0.952
19:111185:T:G	S169R	0.952
19:110692:T:C	F5S	0.947
19:111159:T:C	F161L	0.944
19:111161:C:A	F161L	0.944
19:111161:C:G	F161L	0.944
19:111129:A:C	S151R	0.930
19:111131:C:A	S151R	0.930
19:111131:C:G	S151R	0.930
19:111186:T:C	F170L	0.929
19:111188:T:A	F170L	0.929
19:111188:T:G	F170L	0.929
19:111408:T:C	F244L	0.924
19:111410:T:A	F244L	0.924
19:111410:T:G	F244L	0.924
19:110692:T:G	F5C	0.917
19:111264:A:C	S196R	0.909
19:111266:T:A	S196R	0.909
19:111266:T:G	S196R	0.909
19:110985:A:C	S103R	0.904
19:110987:T:A	S103R	0.904
19:110987:T:G	S103R	0.904
19:111405:T:C	F243L	0.899
19:111407:C:A	F243L	0.899
19:111407:C:G	F243L	0.899
19:111160:T:G	F161C	0.898

dbSNP variants (sampled 300 via entrez): RS1000965221 (19:108647 A>G), RS1001058580 (19:109405 T>C), RS1004862250 (19:113522 A>C), RS1005836534 (19:106420 T>A,C), RS1008387607 (19:108547 T>A,C), RS1008835036 (19:107573 A>C,G), RS1008898598 (19:109278 C>A), RS1012216973 (19:109682 A>C,G), RS1012766177 (19:111762 G>A), RS1014789917 (19:113543 G>A), RS1014820937 (19:110002 T>C,G), RS1015892582 (19:106510 G>C), RS1021035365 (19:107626 G>A), RS1021140973 (19:108564 C>G,T), RS1024945336 (19:111792 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
2-palmitoylglycerol	increases expression	1
Niclosamide	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.