OR4F3

Summary

OR4F3 (olfactory receptor family 4 subfamily F member 3, HGNC:8300) is a protein-coding gene on chromosome 5q35.3, encoding Olfactory receptor 4F3/4F16/4F29 (Q6IEY1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 26683 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 5 total
• MANE Select transcript: NM_001408386

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:8300
Approved symbol	OR4F3
Name	olfactory receptor family 4 subfamily F member 3
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000230178
Ensembl biotype	protein_coding
Entrez	26683

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000456475

RefSeq mRNA: 2 — MANE Select: NM_001408386 NM_001005224, NM_001408386

CCDS: CCDS43415

Canonical transcript exons

ENST00000456475 — 1 exons

Exon	Start	End
ENSE00002321347	181367268	181368262

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 39.22.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	39.22	silver quality
apex of heart	UBERON:0002098	37.70	silver quality
duodenum	UBERON:0002114	37.53	silver quality
corpus callosum	UBERON:0002336	37.22	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
liver	UBERON:0002107	36.99	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
rectum	UBERON:0001052	35.98	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	32.94	gold quality
calcaneal tendon	UBERON:0003701	32.75	gold quality
superior frontal gyrus	UBERON:0002661	32.72	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
tonsil	UBERON:0002372	32.12	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
urinary bladder	UBERON:0001255	31.47	gold quality
placenta	UBERON:0001987	31.46	silver quality
mucosa of stomach	UBERON:0001199	31.44	gold quality
islet of Langerhans	UBERON:0000006	31.39	silver quality
adrenal tissue	UBERON:0018303	31.30	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
cortex of kidney	UBERON:0001225	30.11	gold quality
tibial nerve	UBERON:0001323	29.98	silver quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.64	gold quality
muscle of leg	UBERON:0001383	29.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4f7	ENSMUSG00000093804
rattus_norvegicus		ENSRNOG00000072324
rattus_norvegicus	Or4f7	ENSRNOG00000073873
rattus_norvegicus	Or4f7c	ENSRNOG00000076105

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4F3/4F16/4F29 — Q6IEY1 (reviewed: Q6IEY1)

Alternative names: Olfactory receptor OR1-1

All UniProt accessions (2): Q6IEY1, A0A126GV92

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005224, NP_001395315* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6IEY1-F1	90.04	0.67

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, BIDUS_METASTASIS_UP, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

202 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4F3	ETDA	Q3ZM63	581
OR4F3	TMCO4	Q5TGY1	505
OR4F3	KRTAP1-4	P0C5Y4	479
OR4F3	ZNF232	Q9UNY5	398
OR4F3	ZNF804B	A4D1E1	377
OR4F3	CCDC12	Q8WUD4	374
OR4F3	APCDD1L	Q8NCL9	371
OR4F3	RASL10B	Q96S79	362
OR4F3	DIRAS1	O95057	351
OR4F3	PCDHGA1	Q9Y5H4	350
OR4F3	CWH43	Q9H720	348
OR4F3	ARK2C	Q6ZSG1	348
OR4F3	NYNRIN	Q9P2P1	336
OR4F3	RTL3	Q8N8U3	323
OR4F3	RPS6KC1	Q96S38	321

IntAct

4 interactions, top by confidence:

A	B	Type	Score
UBTFL1	OR4F3	psi-mi:“MI:0915”(physical association)	0.560
UBTFL1	OR4F3	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (4): UBTFL1 (Two-hybrid), OR4F16 (Two-hybrid), OR4F29 (Two-hybrid), OR4F16 (Negative Genetic)

ESM2 similar proteins: A6NHG9, A6NKK0, B2RN74, O76099, O95013, P0C7N8, P0DN80, P34982, P35898, P37067, P37068, P37069, P37071, Q60887, Q6IEY1, Q7TS48, Q8N349, Q8NG80, Q8NG84, Q8NG85, Q8NG92, Q8NG94, Q8NG95, Q8NGA0, Q8NGB8, Q8NGB9, Q8NGD3, Q8NGV7, Q8NGY9, Q8NH07, Q8NH16, Q8NHA4, Q8NHB8, Q8NHC6, Q8NHC7, Q8VEX5, Q8VEX6, Q8VEZ0, Q8VFB9, Q8VG09

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

5 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

274 predictions. Top by Δscore:

Variant	Effect	Δscore
5:181367652:A:G	donor_gain	0.9700
5:181367611:G:GA	donor_gain	0.8900
5:181367396:C:T	donor_gain	0.8400
5:181367310:G:GA	donor_gain	0.8300
5:181367666:G:GG	donor_gain	0.8200
5:181367610:T:TA	donor_gain	0.8100
5:181367308:GTG:G	donor_gain	0.7000
5:181367659:GCCC:G	donor_gain	0.6900
5:181367309:T:TA	donor_gain	0.6300
5:181367906:GT:G	donor_gain	0.5800
5:181367908:G:GG	donor_gain	0.5800
5:181367784:A:AG	acceptor_gain	0.5500
5:181367785:G:GG	acceptor_gain	0.5500
5:181367408:G:GT	donor_gain	0.5400
5:181367349:G:GT	donor_gain	0.5200
5:181367612:G:GG	donor_gain	0.5200
5:181368255:T:G	acceptor_gain	0.5200
5:181367313:ATCTG:A	donor_gain	0.5000
5:181367651:GA:G	donor_gain	0.5000
5:181367662:C:CG	donor_gain	0.5000
5:181367894:G:GG	donor_gain	0.5000
5:181367295:A:T	donor_gain	0.4800
5:181367307:A:AG	donor_gain	0.4700
5:181367311:GTATC:G	donor_gain	0.4700
5:181367312:TATCT:T	donor_gain	0.4700
5:181367665:T:G	donor_gain	0.4700
5:181367897:G:A	donor_gain	0.4700
5:181368139:GTT:G	acceptor_gain	0.4700
5:181367893:A:G	donor_gain	0.4600
5:181368254:AT:A	acceptor_gain	0.4600

AlphaMissense

2038 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:181367788:T:C	F168L	0.867
5:181367790:C:A	F168L	0.867
5:181367790:C:G	F168L	0.867
5:181367320:T:C	F12L	0.861
5:181367322:T:A	F12L	0.861
5:181367322:T:G	F12L	0.861
5:181367815:T:C	F177L	0.858
5:181367817:C:A	F177L	0.858
5:181367817:C:G	F177L	0.858
5:181367398:A:C	S38R	0.738
5:181367400:C:A	S38R	0.738
5:181367400:C:G	S38R	0.738
5:181368037:T:C	F251L	0.728
5:181368039:T:A	F251L	0.728
5:181368039:T:G	F251L	0.728
5:181367812:A:C	S176R	0.720
5:181367814:C:A	S176R	0.720
5:181367814:C:G	S176R	0.720
5:181367566:T:C	F94L	0.693
5:181367568:T:A	F94L	0.693
5:181367568:T:G	F94L	0.693
5:181368034:T:C	F250L	0.679
5:181368036:C:A	F250L	0.679
5:181368036:C:G	F250L	0.679
5:181367590:T:C	F102L	0.677
5:181367592:C:A	F102L	0.677
5:181367592:C:G	F102L	0.677
5:181367321:T:C	F12S	0.675
5:181367770:T:C	F162L	0.658
5:181367772:T:A	F162L	0.658

dbSNP variants (sampled 300 via entrez): RS1000560143 (5:181357992 T>C), RS1001039780 (5:181359829 T>C), RS1003073268 (5:181355974 G>A), RS1004296652 (5:181362525 A>G,T), RS1005039059 (5:181353539 G>A), RS1008145209 (5:181360876 GT>G), RS1008339009 (5:181361888 T>C), RS1011962647 (5:181357744 G>T), RS1012014987 (5:181356343 A>G), RS1016128078 (5:181362554 T>A), RS1019406633 (5:181358556 G>C), RS1019985537 (5:181360967 T>C), RS1023270743 (5:181356539 C>G,T), RS1023429114 (5:181357841 C>T), RS1025736091 (5:181353528 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.