OR4F6

Summary

OR4F6 (olfactory receptor family 4 subfamily F member 6, HGNC:15372) is a protein-coding gene on chromosome 15q26.3, encoding Olfactory receptor 4F6 (Q8NGB9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390648 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 49 total
• MANE Select transcript: NM_001005326

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15372
Approved symbol	OR4F6
Name	olfactory receptor family 4 subfamily F member 6
Location	15q26.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000184140
Ensembl biotype	protein_coding
Entrez	390648

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000328882

RefSeq mRNA: 1 — MANE Select: NM_001005326 NM_001005326

CCDS: CCDS32341

Canonical transcript exons

ENST00000328882 — 2 exons

Exon	Start	End
ENSE00001300880	101805687	101806887
ENSE00003812500	101803509	101803545

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 43.50.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	43.50	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
granulocyte	CL:0000094	36.75	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.55	gold quality
liver	UBERON:0002107	28.84	gold quality
duodenum	UBERON:0002114	28.14	gold quality
primary visual cortex	UBERON:0002436	27.66	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.93	gold quality
blood	UBERON:0000178	26.91	gold quality
urinary bladder	UBERON:0001255	26.71	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
leukocyte	CL:0000738	25.36	gold quality
calcaneal tendon	UBERON:0003701	25.26	gold quality
muscle of leg	UBERON:0001383	25.12	gold quality
frontal cortex	UBERON:0001870	24.86	gold quality
adrenal tissue	UBERON:0018303	24.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4f6	ENSMUSG00000108827
rattus_norvegicus	Or4f6b	ENSRNOG00000076470
rattus_norvegicus	Or4f6	ENSRNOG00000083022

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4F6 — Q8NGB9 (reviewed: Q8NGB9)

Alternative names: Olfactory receptor 4F12, Olfactory receptor OR15-15

All UniProt accessions (2): A0A126GV96, Q8NGB9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005326* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGB9-F1	87.41	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, NIKOLSKY_BREAST_CANCER_15Q26_AMPLICON, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, chr15q26, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, SRSF9_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

194 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4F6	ZNF860	A6NHJ4	621
OR4F6	CCDC63	Q8NA47	544
OR4F6	ZNF229	Q9UJW7	506
OR4F6	TMEM179	Q6ZVK1	480
OR4F6	C14orf180	Q8N912	479
OR4F6	ACAD10	Q6JQN1	477
OR4F6	LPGAT1	Q92604	450
OR4F6	MOB3C	Q70IA8	449
OR4F6	HERPUD2	Q9BSE4	433
OR4F6	TM2D3	Q9BRN9	400
OR4F6	KIF26A	Q9ULI4	358
OR4F6	EBLN2	Q6P2I7	327
OR4F6	DCLRE1C	Q96SD1	301
OR4F6	SLC2A13	Q96QE2	299
OR4F6	TDRD9	Q8NDG6	299

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, A6NMU1, B3DH96, O88628, P0C646, P0C7T3, Q5J3E5, Q5J3G9, Q5J3M9, Q5QD29, Q6IF63, Q6W049, Q8NGB9, Q8NGD3, Q8NGF0, Q8NGF1, Q8NGH6, Q8NGH7, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK5, Q8NGK6, Q8NGV6, Q8NH53, Q8NH55, Q8NH56, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8NHC6, Q8TCB6, Q8VBV9

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

206 predictions. Top by Δscore:

Variant	Effect	Δscore
15:101805782:G:GT	donor_gain	0.9700
15:101805744:GTCTC:G	donor_gain	0.8400
15:101805745:TCTCT:T	donor_gain	0.8400
15:101805841:G:T	donor_gain	0.7800
15:101805718:C:T	donor_gain	0.7400
15:101805743:G:GA	donor_gain	0.7300
15:101805895:T:G	donor_gain	0.7100
15:101805782:G:T	donor_gain	0.7000
15:101805841:G:GT	donor_gain	0.7000
15:101805752:G:GG	donor_gain	0.6900
15:101805726:G:GT	donor_gain	0.6700
15:101805748:C:CG	donor_gain	0.6700
15:101805751:A:AG	donor_gain	0.6500
15:101805826:TGTC:T	donor_gain	0.6400
15:101805723:G:GT	donor_gain	0.6300
15:101805858:C:CG	donor_gain	0.6300
15:101805867:A:AG	donor_gain	0.6200
15:101806384:T:TA	acceptor_gain	0.6200
15:101805792:C:G	donor_gain	0.6100
15:101805868:C:G	donor_gain	0.6000
15:101806510:C:G	acceptor_gain	0.5700
15:101805746:CTCTG:C	donor_gain	0.5600
15:101805742:T:TA	donor_gain	0.5500
15:101805748:C:G	donor_gain	0.5400
15:101805828:TC:T	donor_gain	0.5300
15:101805783:A:T	donor_gain	0.5100
15:101806012:T:TA	donor_gain	0.5000
15:101806013:A:AA	donor_gain	0.5000
15:101805960:A:G	donor_gain	0.4900
15:101806512:T:G	acceptor_gain	0.4900

AlphaMissense

2059 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:101805753:T:C	F12L	0.819
15:101805755:T:A	F12L	0.819
15:101805755:T:G	F12L	0.819
15:101806221:T:C	F168L	0.772
15:101806223:C:A	F168L	0.772
15:101806223:C:G	F168L	0.772
15:101806470:T:C	F251L	0.753
15:101806472:T:A	F251L	0.753
15:101806472:T:G	F251L	0.753
15:101806248:T:C	F177L	0.686
15:101806250:C:A	F177L	0.686
15:101806250:C:G	F177L	0.686
15:101805999:T:C	F94L	0.670
15:101806001:T:A	F94L	0.670
15:101806001:T:G	F94L	0.670
15:101805831:A:C	S38R	0.626
15:101805833:C:A	S38R	0.626
15:101805833:C:G	S38R	0.626
15:101806203:T:C	F162L	0.620
15:101806205:T:A	F162L	0.620
15:101806205:T:G	F162L	0.620
15:101806251:T:C	F178L	0.617
15:101806253:T:A	F178L	0.617
15:101806253:T:G	F178L	0.617
15:101806077:T:C	F120L	0.599
15:101806079:T:A	F120L	0.599
15:101806079:T:G	F120L	0.599
15:101806350:T:C	F211L	0.596
15:101806352:T:A	F211L	0.596
15:101806352:T:G	F211L	0.596

dbSNP variants (sampled 300 via entrez): RS1000022427 (15:101803854 TGA>T), RS1000427828 (15:101804291 C>A,T), RS1001582071 (15:101803776 C>T), RS1001697450 (15:101805318 G>A), RS1001710791 (15:101803497 C>T), RS1001812200 (15:101805625 A>G,T), RS1002557191 (15:101802889 G>A), RS1002667972 (15:101802860 C>G), RS1003768136 (15:101807367 C>A,T), RS1003864216 (15:101801724 A>G), RS1004204298 (15:101807024 C>G,T), RS1004223095 (15:101803549 G>C), RS1004502144 (15:101801980 G>T), RS1004742043 (15:101803789 C>G,T), RS1004963966 (15:101804972 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
hydroxyhydroquinone	increases expression	1
CGP 52608	affects binding, increases reaction	1
Acetaminophen	increases expression	1
Benzo(a)pyrene	affects methylation	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.