OR4K13

Summary

OR4K13 (olfactory receptor family 4 subfamily K member 13, HGNC:15351) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4K13 (Q8NH42). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390433 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_001004714

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15351
Approved symbol	OR4K13
Name	olfactory receptor family 4 subfamily K member 13
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176253
Ensembl biotype	protein_coding
Entrez	390433

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641664, ENST00000641904

RefSeq mRNA: 2 — MANE Select: NM_001004714 NM_001004714, NM_001386029

CCDS: CCDS32028

Canonical transcript exons

ENST00000641904 — 2 exons

Exon	Start	End
ENSE00003812365	20029399	20034981
ENSE00003813304	20035938	20036038

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 43.24.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	43.24	gold quality
colonic epithelium	UBERON:0000397	41.17	gold quality
sural nerve	UBERON:0015488	39.89	gold quality
bone marrow cell	CL:0002092	39.88	gold quality
lower esophagus mucosa	UBERON:0035834	38.01	gold quality
ganglionic eminence	UBERON:0004023	37.13	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow	UBERON:0002371	35.76	gold quality
monocyte	CL:0000576	35.49	gold quality
leukocyte	CL:0000738	35.26	gold quality
granulocyte	CL:0000094	34.44	gold quality
mucosa of transverse colon	UBERON:0004991	34.16	gold quality
liver	UBERON:0002107	33.81	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
primary visual cortex	UBERON:0002436	32.65	gold quality
muscle tissue	UBERON:0002385	32.21	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
adrenal tissue	UBERON:0018303	31.77	gold quality
urinary bladder	UBERON:0001255	31.16	gold quality
fundus of stomach	UBERON:0001160	30.52	gold quality
blood	UBERON:0000178	30.48	gold quality
tonsil	UBERON:0002372	30.10	gold quality
prefrontal cortex	UBERON:0000451	29.94	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
lymph node	UBERON:0000029	29.84	gold quality
right adrenal gland cortex	UBERON:0035827	29.69	gold quality
right lobe of liver	UBERON:0001114	29.61	gold quality
superior frontal gyrus	UBERON:0002661	29.42	gold quality
pancreas	UBERON:0001264	28.92	gold quality
body of pancreas	UBERON:0001150	28.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.92

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4K13 — Q8NH42 (reviewed: Q8NH42)

Alternative names: Olfactory receptor OR14-27

All UniProt accessions (2): A0A126GVS2, Q8NH42

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001004714, NP_001372958 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH42-F1	83.88	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

88 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4K13	CCDC91	Q7Z6B0	477
OR4K13	INPP5B	P32019	391
OR4K13	AP1G1	O43747	371
OR4K13	KCNC2	Q96PR1	348
OR4K13	PIP4K2A	P48426	324
OR4K13	KCNQ5	Q9NR82	311
OR4K13	RXFP1	Q9HBX9	310
OR4K13	SPINT1	O43278	308
OR4K13	CMKLR2	P46091	302
OR4K13	POU3F1	Q03052	290
OR4K13	PLCB1	Q9NQ66	237
OR4K13	KCNQ2	O43526	231
OR4K13	ABCB4	P21439	219
OR4K13	PDPR	Q8NCN5	199
OR4K13	CEACAM4	O75871	196

IntAct

0 interactions, top by confidence:

BioGRID (1): RPL32 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	52
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

278 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20034492:A:AC	donor_gain	0.6800
14:20034493:C:CC	donor_gain	0.6800
14:20034614:CAG:C	donor_gain	0.6700
14:20034616:G:C	donor_gain	0.6300
14:20034493:CGTT:C	donor_gain	0.6100
14:20034207:C:CT	acceptor_gain	0.5900
14:20034727:T:TA	donor_gain	0.5900
14:20034190:T:C	acceptor_gain	0.5500
14:20034734:C:CT	donor_gain	0.5400
14:20034583:A:C	donor_gain	0.5300
14:20034210:A:T	acceptor_gain	0.5000
14:20034754:T:A	donor_gain	0.4900
14:20034251:C:CT	acceptor_gain	0.4800
14:20034085:A:AC	donor_gain	0.4700
14:20034086:C:CC	donor_gain	0.4700
14:20034189:CT:C	acceptor_gain	0.4700
14:20034190:TT:T	acceptor_gain	0.4700
14:20034431:TCCCA:T	donor_gain	0.4700
14:20034432:CCCAC:C	donor_gain	0.4700
14:20034433:CCACC:C	donor_gain	0.4700
14:20034434:CACCC:C	donor_gain	0.4700
14:20034435:ACCCA:A	donor_gain	0.4700
14:20034436:CCCAG:C	donor_gain	0.4700
14:20034734:CCA:C	donor_gain	0.4700
14:20034081:CCTAA:C	donor_gain	0.4600
14:20034471:TCCCC:T	donor_gain	0.4500
14:20034621:CAAGA:C	donor_gain	0.4500
14:20033985:G:C	acceptor_gain	0.4400
14:20034086:C:A	acceptor_gain	0.4400
14:20034735:C:CT	donor_gain	0.4400

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000031384 (14:20035081 G>A), RS1000490138 (14:20036391 C>T), RS1001180230 (14:20034548 T>C), RS1001342959 (14:20031821 T>A,C), RS1001729033 (14:20029061 A>C,G), RS1002334082 (14:20033319 G>C), RS1002404588 (14:20037988 T>C), RS1003128895 (14:20029025 C>A,T), RS1003147838 (14:20032399 A>G,T), RS1003180464 (14:20031989 G>A), RS1003813434 (14:20037081 A>G), RS1004138513 (14:20030129 G>A,T), RS1005101700 (14:20031701 T>G), RS1005152278 (14:20031417 G>A), RS1005729713 (14:20037970 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, decreases methylation	2
bisphenol A	increases methylation, affects cotreatment	1
Fulvestrant	affects cotreatment, increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.