OR4K14

Summary

OR4K14 (olfactory receptor family 4 subfamily K member 14, HGNC:15352) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4K14 (Q8NGD5). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 122740 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 47 total
• MANE Select transcript: NM_001004712

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15352
Approved symbol	OR4K14
Name	olfactory receptor family 4 subfamily K member 14
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000169484
Ensembl biotype	protein_coding
Entrez	122740

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641793

RefSeq mRNA: 1 — MANE Select: NM_001004712 NM_001004712

CCDS: CCDS32027

Canonical transcript exons

ENST00000641793 — 2 exons

Exon	Start	End
ENSE00003811824	20019143	20019307
ENSE00003813210	20014143	20015222

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 38.17.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.17	gold quality
sural nerve	UBERON:0015488	37.89	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
mucosa of stomach	UBERON:0001199	33.32	gold quality
bone marrow	UBERON:0002371	32.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
liver	UBERON:0002107	28.59	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
leukocyte	CL:0000738	27.29	gold quality
monocyte	CL:0000576	27.26	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.73	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
blood	UBERON:0000178	25.85	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.74	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
pancreas	UBERON:0001264	23.89	gold quality
right lobe of liver	UBERON:0001114	23.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.97

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 4K14 — Q8NGD5 (reviewed: Q8NGD5)

Alternative names: Olfactory receptor OR14-22

All UniProt accessions (2): A0A126GVP2, Q8NGD5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004712* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGD5-F1	85.89	0.52

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr14q11

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

160 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4K14	IZUMO2	Q6UXV1	507
OR4K14	PCDHGA2	Q9Y5H1	430
OR4K14	TOP6BL	Q8N6T0	419
OR4K14	PCDHGA3	Q9Y5H0	418
OR4K14	ZNF473	Q8WTR7	418
OR4K14	CCDC85A	Q96PX6	412
OR4K14	KLHL4	Q9C0H6	399
OR4K14	RNASE13	Q5GAN3	399
OR4K14	PCDHGA1	Q9Y5H4	397
OR4K14	CCDC91	Q7Z6B0	396
OR4K14	TMEM132C	Q8N3T6	380
OR4K14	FAM133A	Q8N9E0	379
OR4K14	NAP1L3	Q99457	370
OR4K14	TMEM132D	Q14C87	370
OR4K14	PABPC5	Q96DU9	348

IntAct

0 interactions, top by confidence:

BioGRID (1): OR4K14 (Protein-peptide)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	45
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

364 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20014346:A:T	acceptor_gain	0.7900
14:20014535:G:GC	acceptor_gain	0.7600
14:20014345:C:CT	acceptor_gain	0.7400
14:20014531:CACGG:C	acceptor_gain	0.7200
14:20014546:C:CT	acceptor_gain	0.6900
14:20014412:C:CT	acceptor_gain	0.6800
14:20014417:A:C	acceptor_gain	0.6800
14:20014533:CGG:C	acceptor_gain	0.6800
14:20014547:A:T	acceptor_gain	0.6600
14:20014414:CACA:C	acceptor_gain	0.6500
14:20014416:CA:C	acceptor_gain	0.6500
14:20014324:CAA:C	acceptor_gain	0.6300
14:20014412:C:T	acceptor_gain	0.6300
14:20014566:T:TG	acceptor_gain	0.6200
14:20014326:A:C	acceptor_gain	0.6100
14:20014417:A:AC	acceptor_gain	0.6100
14:20014355:G:GC	acceptor_gain	0.6000
14:20014366:A:C	acceptor_gain	0.6000
14:20014403:C:CC	acceptor_gain	0.6000
14:20014870:A:T	acceptor_gain	0.6000
14:20015015:A:C	acceptor_gain	0.6000
14:20015164:TGA:T	donor_gain	0.5900
14:20014328:G:C	acceptor_gain	0.5800
14:20014417:A:T	acceptor_gain	0.5800
14:20014825:T:C	donor_gain	0.5800
14:20014334:A:C	acceptor_gain	0.5700
14:20014903:T:TA	donor_gain	0.5700
14:20015091:AGACC:A	donor_gain	0.5700
14:20014398:AC:A	acceptor_loss	0.5600
14:20014400:C:CA	acceptor_loss	0.5600

AlphaMissense

2046 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:20015158:A:C	F12L	0.936
14:20015158:A:T	F12L	0.936
14:20015160:A:G	F12L	0.936
14:20015159:A:C	F12C	0.892
14:20014438:A:C	F252L	0.886
14:20014438:A:T	F252L	0.886
14:20014440:A:G	F252L	0.886
14:20014657:G:C	F179L	0.884
14:20014657:G:T	F179L	0.884
14:20014659:A:G	F179L	0.884
14:20014717:A:C	S159R	0.877
14:20014717:A:T	S159R	0.877
14:20014719:T:G	S159R	0.877
14:20014663:G:C	S177R	0.875
14:20014663:G:T	S177R	0.875
14:20014665:T:G	S177R	0.875
14:20014564:G:C	S210R	0.874
14:20014564:G:T	S210R	0.874
14:20014566:T:G	S210R	0.874
14:20014660:G:C	F178L	0.872
14:20014660:G:T	F178L	0.872
14:20014662:A:G	F178L	0.872
14:20014582:A:C	S204R	0.863
14:20014582:A:T	S204R	0.863
14:20014584:T:G	S204R	0.863
14:20015159:A:G	F12S	0.859
14:20014655:C:G	C180S	0.857
14:20014656:A:T	C180S	0.857
14:20014441:G:C	F251L	0.856
14:20014441:G:T	F251L	0.856

dbSNP variants (sampled 300 via entrez): RS1000274385 (14:20013958 T>C), RS1001328735 (14:20015272 T>C), RS1001925315 (14:20016373 G>A), RS1002021115 (14:20017849 T>C,G), RS1002315542 (14:20016607 T>C), RS1002917192 (14:20017855 C>A,T), RS1003337743 (14:20017673 G>A,T), RS1003643747 (14:20014838 A>G), RS1003822014 (14:20020463 C>T), RS1003912444 (14:20018499 T>C), RS1003931523 (14:20018655 G>A), RS1004723760 (14:20015147 C>T), RS1004919331 (14:20020385 T>C), RS1005176470 (14:20014704 T>C), RS1005918561 (14:20015999 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.