OR4K15

Summary

OR4K15 (olfactory receptor family 4 subfamily K member 15, HGNC:15353) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4K15 (Q8NH41). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81127 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 77 total
• MANE Select transcript: NM_001005486

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15353
Approved symbol	OR4K15
Name	olfactory receptor family 4 subfamily K member 15
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	OR4K15Q
Ensembl gene	ENSG00000169488
Ensembl biotype	protein_coding
Entrez	81127

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000305051

RefSeq mRNA: 1 — MANE Select: NM_001005486 NM_001005486

CCDS: CCDS32026

Canonical transcript exons

ENST00000305051 — 1 exons

Exon	Start	End
ENSE00001635862	19975591	19976565

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 92.46.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	92.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.00	gold quality
sural nerve	UBERON:0015488	37.66	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.22	gold quality
liver	UBERON:0002107	29.14	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	27.80	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
blood	UBERON:0000178	26.42	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
leukocyte	CL:0000738	26.23	gold quality
monocyte	CL:0000576	26.10	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
ectocervix	UBERON:0012249	25.23	gold quality
right lobe of liver	UBERON:0001114	25.21	gold quality
uterine cervix	UBERON:0000002	25.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.97

Regulation

Is transcription factor: no

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4k15	ENSMUSG00000059488
mus_musculus	Or4k15c	ENSMUSG00000060523
mus_musculus	Or4k15b	ENSMUSG00000068437
rattus_norvegicus	Or4k15	ENSRNOG00000075034
rattus_norvegicus	Or4k15c	ENSRNOG00000084853

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200), OR4K17 (ENSG00000176230)

Protein

Protein identifiers

Olfactory receptor 4K15 — Q8NH41 (reviewed: Q8NH41)

Alternative names: Olfactory receptor OR14-20

All UniProt accessions (1): Q8NH41

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005486* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (25 total): topological domain 8, transmembrane region 7, sequence variant 6, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH41-F1	83.12	0.37

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 2, 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 21 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, SRSF9_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, MATSUMIYA_PBMC_MODIFIED_VACCINIA_ANKARA_VACCINE_AGE_18_55YO_VACCINATED_VS_CONTROL_TREATED_IN_VITRO_WITH_WILD_TYPE_MVA_6HR_UP

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

132 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4K15	CPEB3	Q8NE35	930
OR4K15	TTC13	Q8NBP0	621
OR4K15	IGF1R	P08069	585
OR4K15	TPGS1	Q6ZTW0	564
OR4K15	PNKP	Q96T60	545
OR4K15	ZNF99	A8MXY4	447
OR4K15	YPEL4	Q96NS1	417
OR4K15	ZNF652	Q9Y2D9	403
OR4K15	TAS2R16	Q9NYV7	391
OR4K15	THSD7B	Q9C0I4	367
OR4K15	NLRP11	P59045	348
OR4K15	TAAR5	O14804	323
OR4K15	LAIR2	Q6ISS4	306
OR4K15	ATP6V0C	P27449	253
OR4K15	TRHR	P34981	253

IntAct

0 interactions, top by confidence:

BioGRID (1): OR4K15 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	72
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

133 predictions. Top by Δscore:

Variant	Effect	Δscore
14:19975653:G:GT	donor_gain	0.7400
14:19976263:GTTA:G	acceptor_gain	0.6700
14:19976262:A:AG	acceptor_gain	0.6600
14:19976263:G:GG	acceptor_gain	0.6600
14:19976245:A:AG	acceptor_gain	0.6400
14:19976231:T:TA	acceptor_gain	0.6300
14:19976263:GTT:G	acceptor_gain	0.6300
14:19976245:ACT:A	acceptor_gain	0.6100
14:19976250:A:AG	acceptor_gain	0.6100
14:19976261:CAGTT:C	acceptor_gain	0.6100
14:19976262:AGTTA:A	acceptor_gain	0.6100
14:19976263:GTTAG:G	acceptor_gain	0.6100
14:19976243:A:AG	acceptor_gain	0.6000
14:19975654:G:T	donor_gain	0.5900
14:19976251:A:G	acceptor_gain	0.5700
14:19976259:TACAG:T	acceptor_gain	0.5600
14:19975653:G:T	donor_gain	0.5500
14:19976246:C:G	acceptor_gain	0.5500
14:19976244:C:G	acceptor_gain	0.5300
14:19976243:ACACT:A	acceptor_gain	0.5200
14:19976253:A:AG	acceptor_gain	0.5000
14:19976260:ACAGT:A	acceptor_gain	0.5000
14:19976364:T:G	acceptor_gain	0.5000
14:19976247:T:A	acceptor_gain	0.4900
14:19976263:GT:G	acceptor_gain	0.4900
14:19975766:T:G	donor_gain	0.4800
14:19975618:A:AG	donor_gain	0.4700
14:19975617:GAC:G	donor_gain	0.4300
14:19976253:ACTT:A	acceptor_gain	0.4300
14:19976382:T:G	donor_gain	0.4300

AlphaMissense

2266 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:19975624:T:C	F36L	0.920
14:19975626:T:A	F36L	0.920
14:19975626:T:G	F36L	0.920
14:19976092:T:C	F192L	0.881
14:19976094:T:A	F192L	0.881
14:19976094:T:G	F192L	0.881
14:19976341:T:C	F275L	0.796
14:19976343:T:A	F275L	0.796
14:19976343:T:G	F275L	0.796
14:19976119:T:C	F201L	0.793
14:19976121:T:A	F201L	0.793
14:19976121:T:G	F201L	0.793
14:19975681:T:C	F55L	0.787
14:19975683:T:A	F55L	0.787
14:19975683:T:G	F55L	0.787
14:19976122:T:C	F202L	0.787
14:19976124:C:A	F202L	0.787
14:19976124:C:G	F202L	0.787
14:19976215:A:C	S233R	0.775
14:19976217:T:A	S233R	0.775
14:19976217:T:G	S233R	0.775
14:19975625:T:G	F36C	0.747
14:19976374:T:C	F286L	0.740
14:19976376:C:A	F286L	0.740
14:19976376:C:G	F286L	0.740
14:19975918:A:C	S134R	0.737
14:19975920:T:A	S134R	0.737
14:19975920:T:G	S134R	0.737
14:19976074:T:C	F186L	0.725
14:19976076:C:A	F186L	0.725

dbSNP variants (sampled 300 via entrez): RS1000276809 (14:19975335 A>G), RS1000287948 (14:19975068 A>G), RS1005430621 (14:19973925 T>C), RS1007048797 (14:19973872 G>A), RS1009427505 (14:19975015 C>A,T), RS1010439754 (14:19973601 G>A,C,T), RS10135246 (14:19976282 C>A), RS10135467 (14:19976448 C>G), RS1013743253 (14:19975994 T>C), RS1014821009 (14:19976733 A>G), RS1015676721 (14:19975398 A>C), RS1016682279 (14:19973961 A>G), RS1020408211 (14:19974622 A>C), RS1023636525 (14:19976802 A>G), RS1025588143 (14:19973726 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Zoledronic Acid	increases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.