OR4K17

Summary

OR4K17 (olfactory receptor family 4 subfamily K member 17, HGNC:15355) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4K17 (Q8NGC6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390436 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 79 total
• MANE Select transcript: NM_001004715

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15355
Approved symbol	OR4K17
Name	olfactory receptor family 4 subfamily K member 17
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176230
Ensembl biotype	protein_coding
Entrez	390436

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641386, ENST00000641633

RefSeq mRNA: 1 — MANE Select: NM_001004715 NM_001004715

CCDS: CCDS32030

Canonical transcript exons

ENST00000641386 — 2 exons

Exon	Start	End
ENSE00003812010	20110739	20110892
ENSE00003812636	20117468	20122199

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 51.60.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	51.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	41.73	gold quality
cortical plate	UBERON:0005343	39.90	gold quality
ventricular zone	UBERON:0003053	39.81	gold quality
bone marrow	UBERON:0002371	39.31	gold quality
stromal cell of endometrium	CL:0002255	38.75	gold quality
liver	UBERON:0002107	38.42	silver quality
skeletal muscle tissue	UBERON:0001134	38.08	gold quality
bone marrow cell	CL:0002092	38.00	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ganglionic eminence	UBERON:0004023	37.10	gold quality
right lobe of liver	UBERON:0001114	36.92	gold quality
blood	UBERON:0000178	36.74	gold quality
muscle tissue	UBERON:0002385	36.67	gold quality
duodenum	UBERON:0002114	36.57	gold quality
leukocyte	CL:0000738	36.13	gold quality
monocyte	CL:0000576	35.30	gold quality
granulocyte	CL:0000094	34.89	gold quality
vermiform appendix	UBERON:0001154	34.88	gold quality
apex of heart	UBERON:0002098	34.59	gold quality
lymph node	UBERON:0000029	34.47	gold quality
right coronary artery	UBERON:0001625	34.28	gold quality
adrenal tissue	UBERON:0018303	32.85	gold quality
mucosa of stomach	UBERON:0001199	32.73	gold quality
adult mammalian kidney	UBERON:0000082	32.68	gold quality
prefrontal cortex	UBERON:0000451	32.68	gold quality
kidney	UBERON:0002113	32.47	gold quality
urinary bladder	UBERON:0001255	32.42	gold quality
popliteal artery	UBERON:0002250	32.27	gold quality
tibial artery	UBERON:0007610	32.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.75

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4K17 — Q8NGC6 (reviewed: Q8NGC6)

Alternative names: Olfactory receptor OR14-29

All UniProt accessions (1): Q8NGC6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004715* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGC6-F1	86.44	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 264

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 23 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, PEDRIOLI_MIR31_TARGETS_UP, CHAMP1_TARGET_GENES, MAFG_TARGET_GENES, NFE2L1_TARGET_GENES, ZNF766_TARGET_GENES

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

226 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4K17	MYO3B	Q8WXR4	575
OR4K17	MYO18B	Q8IUG5	542
OR4K17	MYH3	P11055	474
OR4K17	MYH10	P35580	474
OR4K17	RFTN1	Q14699	469
OR4K17	KIF26B	Q2KJY2	431
OR4K17	LTBP1	P22064	289
OR4K17	MYOM1	P52179	280
OR4K17	TTC13	Q8NBP0	270
OR4K17	TAS2R60	P59551	269
OR4K17	TPGS1	Q6ZTW0	247
OR4K17	RTP1	P59025	216
OR4K17	PCBP3	P57721	212
OR4K17	OR52E2	Q8NGJ4	212
OR4K17	SCN9A	Q15858	195

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR4K17	PLEC	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (2): OR4K17 (Proximity Label-MS), RBBP7 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NCV1, O95221, P0C7N1, P0C7N5, Q60881, Q60888, Q6IEU7, Q8NGA8, Q8NGB6, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD4, Q8NGD5, Q8NGE8, Q8NGF8, Q8NGI4, Q8NGI6, Q8NGJ1, Q8NGM9, Q8NGP8, Q8NGP9, Q8NGS9, Q8NGT0, Q8NH01, Q8NH10, Q8NH18, Q8NH21, Q8NH41, Q8NH42, Q8NH43, Q8NH49, Q8NH69, Q8NH85, Q8VEW5, Q8VF65, Q8VFD3

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	78
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

212 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20117563:G:GT	donor_gain	1.0000
14:20117568:AG:A	donor_gain	0.9500
14:20117562:GGAT:G	donor_gain	0.9400
14:20117567:TA:T	donor_gain	0.8800
14:20117565:T:G	donor_gain	0.8600
14:20118154:A:AG	acceptor_gain	0.8600
14:20118155:G:GG	acceptor_gain	0.8600
14:20117563:G:T	donor_gain	0.8500
14:20117607:G:GA	donor_gain	0.8300
14:20118154:AGTCT:A	acceptor_gain	0.7800
14:20118155:GTCTG:G	acceptor_gain	0.7800
14:20118155:GTCT:G	acceptor_gain	0.7500
14:20117569:GA:G	donor_gain	0.6800
14:20117819:T:A	acceptor_gain	0.6700
14:20118155:GT:G	acceptor_gain	0.6300
14:20118155:GTC:G	acceptor_gain	0.6200
14:20117483:GCT:G	donor_gain	0.6100
14:20117524:GT:G	donor_gain	0.6100
14:20117563:GAT:G	donor_gain	0.6100
14:20117599:A:AG	donor_gain	0.6100
14:20117566:G:GG	donor_gain	0.5300
14:20117609:TCA:T	donor_gain	0.5300
14:20117610:CAC:C	donor_gain	0.5300
14:20117611:ACA:A	donor_gain	0.5300
14:20117621:G:GG	donor_gain	0.5200
14:20117528:C:A	donor_gain	0.4900
14:20117598:T:A	donor_gain	0.4900
14:20117624:A:AG	donor_gain	0.4900
14:20118150:CTACA:C	acceptor_loss	0.4900
14:20118151:TACAG:T	acceptor_loss	0.4900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000206592 (14:20110033 A>C,G), RS1000360711 (14:20116277 T>C), RS1000520950 (14:20120985 A>G), RS1000551982 (14:20121340 T>C), RS1000556812 (14:20115504 T>C), RS1000618717 (14:20109253 G>A,C), RS1000658297 (14:20120733 G>A,C), RS1001031543 (14:20109445 G>A), RS1001211242 (14:20111141 T>C), RS1001420938 (14:20117269 C>A), RS1001522506 (14:20122396 G>T), RS1001658084 (14:20122122 C>T), RS1001720245 (14:20114965 T>A), RS1002143081 (14:20120070 G>A,T), RS1002210232 (14:20112594 C>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.