OR4K5

Summary

OR4K5 (olfactory receptor family 4 subfamily K member 5, HGNC:14745) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4K5 (Q8NGD3). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 79317 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• MANE Select transcript: NM_001005483

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14745
Approved symbol	OR4K5
Name	olfactory receptor family 4 subfamily K member 5
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176281
Ensembl biotype	protein_coding
Entrez	79317

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000315915

RefSeq mRNA: 1 — MANE Select: NM_001005483 NM_001005483

CCDS: CCDS32024

Canonical transcript exons

ENST00000315915 — 1 exons

Exon	Start	End
ENSE00004001346	19920607	19921578

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 39.15.

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	39.15	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.83	gold quality
monocyte	CL:0000576	26.76	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
blood	UBERON:0000178	26.44	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	24.87	gold quality
adrenal tissue	UBERON:0018303	24.85	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.37	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality
endocervix	UBERON:0000458	23.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4k5	ENSMUSG00000049011
rattus_norvegicus	Or4k5	ENSRNOG00000012515

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4K5 — Q8NGD3 (reviewed: Q8NGD3)

Alternative names: Olfactory receptor OR14-16

All UniProt accessions (2): A0A126GVN5, Q8NGD3

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005483* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGD3-F1	85.35	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 22 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, RAO_BOUND_BY_SALL4_ISOFORM_A, SRSF9_TARGET_GENES, ZFP91_TARGET_GENES

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

260 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4K5	TTC16	Q8NEE8	529
OR4K5	POTEM	A6NI47	418
OR4K5	GPR108	Q9NPR9	414
OR4K5	SLC6A18	Q96N87	392
OR4K5	PEG3	P78418	328
OR4K5	CCDC91	Q7Z6B0	322
OR4K5	MICAL3	Q7RTP6	317
OR4K5	TGS1	Q96RS0	306
OR4K5	OR4M1	Q8NGD0	299
OR4K5	RTP2	Q5QGT7	294
OR4K5	DCTN2	Q13561	291
OR4K5	RIC8B	Q9NVN3	280
OR4K5	RTP1	P59025	274
OR4K5	OR4Q3	Q8NH05	271
OR4K5	ZNF737	O75373	270
OR4K5	CCNB1IP1	Q9NPC3	270

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, A6NMU1, B3DH96, O88628, P0C646, P0C7T3, Q5J3E5, Q5J3G9, Q5J3M9, Q5QD29, Q6IF63, Q6W049, Q8NGB9, Q8NGD3, Q8NGF0, Q8NGF1, Q8NGH6, Q8NGH7, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK5, Q8NGK6, Q8NGV6, Q8NH53, Q8NH55, Q8NH56, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8NHC6, Q8TCB6, Q8VBV9

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

174 predictions. Top by Δscore:

Variant	Effect	Δscore
14:19920610:GA:G	donor_gain	0.7800
14:19920611:A:G	donor_gain	0.7700
14:19921278:A:AG	acceptor_gain	0.7100
14:19921279:G:GG	acceptor_gain	0.7100
14:19920630:G:GA	donor_gain	0.7000
14:19920609:GGA:G	donor_gain	0.6800
14:19921279:GTTT:G	acceptor_gain	0.6600
14:19921278:AGTTT:A	acceptor_gain	0.6500
14:19921279:GTTTG:G	acceptor_gain	0.6500
14:19920611:A:AG	donor_gain	0.6200
14:19921247:TGG:T	acceptor_gain	0.6100
14:19921342:G:GG	donor_gain	0.6100
14:19920628:G:GG	donor_gain	0.6000
14:19921248:GGT:G	acceptor_gain	0.6000
14:19920627:A:AG	donor_gain	0.5900
14:19920755:C:G	donor_gain	0.5900
14:19920629:T:TA	donor_gain	0.5800
14:19920779:C:G	donor_gain	0.5800
14:19921342:G:GT	donor_gain	0.5800
14:19921343:T:TT	donor_gain	0.5800
14:19921344:A:AT	donor_gain	0.5800
14:19921341:A:AG	donor_gain	0.5700
14:19920779:C:CG	donor_gain	0.5500
14:19920615:G:GG	donor_gain	0.5400
14:19920627:AGT:A	donor_gain	0.5400
14:19920660:T:TA	donor_gain	0.5300
14:19920661:A:AA	donor_gain	0.5300
14:19920614:A:AG	donor_gain	0.5200
14:19921249:GT:G	acceptor_gain	0.5100
14:19921409:A:G	donor_gain	0.5000

AlphaMissense

2119 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:19921108:T:C	F168L	0.911
14:19921110:T:A	F168L	0.911
14:19921110:T:G	F168L	0.911
14:19920640:T:C	F12L	0.904
14:19920642:T:A	F12L	0.904
14:19920642:T:G	F12L	0.904
14:19921357:T:C	F251L	0.876
14:19921359:T:A	F251L	0.876
14:19921359:T:G	F251L	0.876
14:19921231:A:C	S209R	0.873
14:19921233:C:A	S209R	0.873
14:19921233:C:G	S209R	0.873
14:19921138:T:C	F178L	0.852
14:19921140:T:A	F178L	0.852
14:19921140:T:G	F178L	0.852
14:19921078:A:C	S158R	0.850
14:19921080:C:A	S158R	0.850
14:19921080:C:G	S158R	0.850
14:19921135:T:C	F177L	0.846
14:19921137:T:A	F177L	0.846
14:19921137:T:G	F177L	0.846
14:19921060:A:C	S152R	0.844
14:19921062:C:A	S152R	0.844
14:19921062:C:G	S152R	0.844
14:19921132:A:C	S176R	0.828
14:19921134:C:A	S176R	0.828
14:19921134:C:G	S176R	0.828
14:19921354:T:C	F250L	0.827
14:19921356:C:A	F250L	0.827
14:19921356:C:G	F250L	0.827

dbSNP variants (sampled 300 via entrez): RS1003426176 (14:19919133 C>T), RS1003496858 (14:19918905 A>G), RS1005428596 (14:19921409 A>G), RS1008841621 (14:19919513 T>A,C), RS1009814833 (14:19920885 T>C), RS1010707282 (14:19920043 A>C), RS1012228440 (14:19919395 A>G,T), RS1012297531 (14:19921890 G>T), RS1013306264 (14:19919850 G>A), RS1013307424 (14:19920221 G>A), RS1013651660 (14:19920528 T>A,C), RS1013754752 (14:19920028 T>C), RS1013779973 (14:19920447 T>C), RS1014360141 (14:19921240 T>C), RS1014576061 (14:19920009 A>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002934_11	Zinc levels	4.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases methylation	1
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.