OR4M2

Summary

OR4M2 (olfactory receptor family 4 subfamily M member 2, HGNC:15373) is a protein-coding gene on chromosome 15q11.2, encoding Olfactory receptor 4M2 (Q8NGB6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390538 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 52 total
• MANE Select transcript: NM_001004719

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15373
Approved symbol	OR4M2
Name	olfactory receptor family 4 subfamily M member 2
Location	15q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000274102
Ensembl biotype	protein_coding
Entrez	390538

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000614722, ENST00000638815

RefSeq mRNA: 1 — MANE Select: NM_001004719 NM_001004719

CCDS: CCDS32172

Canonical transcript exons

ENST00000614722 — 1 exons

Exon	Start	End
ENSE00003746969	22080527	22081610

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 85.33.

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.27	gold quality
left testis	UBERON:0004533	63.68	gold quality
testis	UBERON:0000473	63.05	gold quality
right testis	UBERON:0004534	60.65	gold quality
bone marrow cell	CL:0002092	48.37	silver quality
bone marrow	UBERON:0002371	39.27	gold quality
granulocyte	CL:0000094	37.92	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
mucosa of stomach	UBERON:0001199	35.97	silver quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	35.03	gold quality
muscle tissue	UBERON:0002385	32.27	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
leukocyte	CL:0000738	28.99	gold quality
monocyte	CL:0000576	28.47	gold quality
urinary bladder	UBERON:0001255	28.22	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
muscle of leg	UBERON:0001383	27.30	silver quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gastrocnemius	UBERON:0001388	26.42	silver quality
blood	UBERON:0000178	26.35	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4m1	ENSMUSG00000045306
rattus_norvegicus	Or4m1	ENSRNOG00000012545

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4M2 — Q8NGB6 (reviewed: Q8NGB6)

Alternative names: Olfactory receptor OR15-3

All UniProt accessions (1): Q8NGB6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004719* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGB6-F1	86.14	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, chr15q11, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, CAMPS_COLON_CANCER_COPY_NUMBER_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

180 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4M2	GOLGA8CP	A6NN73	660
OR4M2	ZNF816	Q0VGE8	507
OR4M2	GOLGA6L1	Q8N7Z2	507
OR4M2	ANKRD20A1	Q5TYW2	471
OR4M2	KRTAP5-10	Q6L8G5	447
OR4M2	GOLGA6L6	A8MZA4	447
OR4M2	HNRNPCL1	O60812	399
OR4M2	ARL5C	A6NH57	398
OR4M2	CIMAP1D	Q3SX64	397
OR4M2	FAM89B	Q8N5H3	397
OR4M2	RNF133	Q8WVZ7	395
OR4M2	RNF148	Q8N7C7	394
OR4M2	GOLGA8S	H3BPF8	377
OR4M2	FAM72B	Q86X60	367
OR4M2	GOLGA8M	H3BSY2	367

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	48
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

144 predictions. Top by Δscore:

Variant	Effect	Δscore
15:22080692:TCC:T	donor_gain	0.8700
15:22080746:G:GT	donor_gain	0.8300
15:22080651:GAC:G	donor_gain	0.7400
15:22080652:ACA:A	donor_gain	0.7400
15:22080653:C:G	donor_gain	0.7200
15:22080693:C:A	donor_gain	0.7000
15:22080747:A:T	donor_gain	0.7000
15:22080855:A:AG	acceptor_gain	0.6600
15:22080856:G:GG	acceptor_gain	0.6600
15:22080945:T:A	acceptor_gain	0.6300
15:22080838:T:TA	acceptor_gain	0.6000
15:22080891:G:GT	donor_gain	0.5600
15:22080650:TG:T	donor_gain	0.5100
15:22080856:GCC:G	acceptor_gain	0.4800
15:22080856:GCCC:G	acceptor_gain	0.4700
15:22080856:GCCCC:G	acceptor_gain	0.4300
15:22080851:TTACA:T	acceptor_loss	0.4100
15:22080852:TACAG:T	acceptor_loss	0.4100
15:22080853:ACAG:A	acceptor_loss	0.4100
15:22080854:CA:C	acceptor_loss	0.4100
15:22080855:A:T	acceptor_loss	0.4100
15:22080856:G:GT	acceptor_loss	0.4100
15:22081314:CTCAG:C	donor_loss	0.4100
15:22081315:TCAG:T	donor_loss	0.4100
15:22081316:CAGG:C	donor_loss	0.4100
15:22081317:AGGT:A	donor_loss	0.4100
15:22081318:GG:G	donor_loss	0.4100
15:22081319:GTG:G	donor_loss	0.4100
15:22081320:T:G	donor_loss	0.4100
15:22080854:C:G	acceptor_loss	0.4000

AlphaMissense

2057 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:22080658:T:C	F12L	0.804
15:22080660:T:A	F12L	0.804
15:22080660:T:G	F12L	0.804
15:22081126:T:C	F168L	0.800
15:22081128:C:A	F168L	0.800
15:22081128:C:G	F168L	0.800
15:22081381:T:C	F253L	0.738
15:22081383:T:A	F253L	0.738
15:22081383:T:G	F253L	0.738
15:22081156:T:C	F178L	0.704
15:22081158:C:A	F178L	0.704
15:22081158:C:G	F178L	0.704
15:22081414:T:C	F264L	0.683
15:22081416:T:A	F264L	0.683
15:22081416:T:G	F264L	0.683
15:22080904:T:C	F94L	0.655
15:22080906:T:A	F94L	0.655
15:22080906:T:G	F94L	0.655
15:22080928:T:C	F102L	0.624
15:22080930:C:A	F102L	0.624
15:22080930:C:G	F102L	0.624
15:22081465:T:C	F281L	0.619
15:22081467:C:A	F281L	0.619
15:22081467:C:G	F281L	0.619
15:22080805:T:C	F61L	0.611
15:22080807:C:A	F61L	0.611
15:22080807:C:G	F61L	0.611
15:22080715:T:C	F31L	0.595
15:22080717:T:A	F31L	0.595
15:22080717:T:G	F31L	0.595

dbSNP variants (sampled 300 via entrez): RS10048049 (15:22081422 G>A), RS1009532979 (15:22080345 G>T), RS1028178123 (15:22078803 ATTTAC>A), RS1037283790 (15:22081921 T>G), RS1050138751 (15:22080401 A>G), RS111484216 (15:22080637 A>C,G), RS112270024 (15:22080824 C>G,T), RS112370472 (15:22081181 G>A), RS112438092 (15:22081031 T>A,C), RS11259845 (15:22081392 C>T), RS112707340 (15:22081250 T>C), RS112881776 (15:22079392 G>C), RS113190362 (15:22080289 C>G,T), RS113687535 (15:22079443 G>C,T), RS113855656 (15:22080517 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	increases reaction, affects binding	1
Benzo(a)pyrene	increases methylation	1
Tobacco Smoke Pollution	affects expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.