OR4M2B

Summary

OR4M2B (olfactory receptor family 4 subfamily M member 2B, HGNC:55109) is a protein-coding gene on chromosome 15q11.2, encoding Olfactory receptor 4M2B (A0A0X1KG70). Odorant receptor.

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 118568804 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001395296

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55109
Approved symbol	OR4M2B
Name	olfactory receptor family 4 subfamily M member 2B
Location	15q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000182974
Ensembl biotype	protein_coding
Entrez	118568804

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000332663

RefSeq mRNA: 1 — MANE Select: NM_001395296 NM_001395296

CCDS: CCDS91960

Canonical transcript exons

ENST00000332663 — 1 exons

Exon	Start	End
ENSE00001729110	21637909	21638992

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 73.63.

Top tissues by expression

124 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	73.63	gold quality
bone marrow cell	CL:0002092	41.91	gold quality
ventricular zone	UBERON:0003053	40.59	silver quality
colonic epithelium	UBERON:0000397	37.20	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow	UBERON:0002371	35.92	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	34.94	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
tonsil	UBERON:0002372	30.02	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
right testis	UBERON:0004534	29.87	silver quality
testis	UBERON:0000473	29.13	gold quality
left testis	UBERON:0004533	29.06	silver quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.31	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
primary visual cortex	UBERON:0002436	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
leukocyte	CL:0000738	26.32	gold quality
monocyte	CL:0000576	26.19	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
blood	UBERON:0000178	25.86	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4m1	ENSMUSG00000045306
rattus_norvegicus	Or4m1	ENSRNOG00000012545

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4M2B — A0A0X1KG70 (reviewed: A0A0X1KG70)

All UniProt accessions (1): A0A0X1KG70

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001382225* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A0X1KG70-F1	87.89	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 13 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, chr15q11, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (3): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

18 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4M2B	TAS2R1	Q9NYW7	159
OR4M2B	HAUS3	Q68CZ6	73
OR4M2B	GNAL	P38405	54
OR4M2B	GNAS	Q5JWF2	54
OR4M2B	RNF222	A6NCQ9	0
OR4M2B	SSTR3	P32745	0
OR4M2B	TAS2R39	P59534	0
OR4M2B	TAS2R40	P59535	0
OR4M2B	GPR34	Q9UPC5	0

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:21638040:T:C	F12L	0.852
15:21638042:T:A	F12L	0.852
15:21638042:T:G	F12L	0.852
15:21638508:T:C	F168L	0.828
15:21638510:C:A	F168L	0.828
15:21638510:C:G	F168L	0.828
15:21638763:T:C	F253L	0.786
15:21638765:T:A	F253L	0.786
15:21638765:T:G	F253L	0.786
15:21638538:T:C	F178L	0.773
15:21638540:C:A	F178L	0.773
15:21638540:C:G	F178L	0.773
15:21638286:T:C	F94L	0.691
15:21638288:T:A	F94L	0.691
15:21638288:T:G	F94L	0.691
15:21638796:T:C	F264L	0.673
15:21638798:T:A	F264L	0.673
15:21638798:T:G	F264L	0.673
15:21638310:T:C	F102L	0.663
15:21638312:C:A	F102L	0.663
15:21638312:C:G	F102L	0.663
15:21638187:T:C	F61L	0.648
15:21638189:C:A	F61L	0.648
15:21638189:C:G	F61L	0.648
15:21638088:T:C	F28L	0.634
15:21638090:T:A	F28L	0.634
15:21638090:T:G	F28L	0.634
15:21638097:T:C	F31L	0.633
15:21638099:T:A	F31L	0.633
15:21638099:T:G	F31L	0.633

dbSNP variants (sampled 300 via entrez): RS1156395675 (15:21639177 GA>G), RS1157034015 (15:21636397 G>A), RS1157433257 (15:21638278 T>C), RS1157548334 (15:21637393 A>G,T), RS1158209962 (15:21638656 C>T), RS1158653471 (15:21636122 A>G), RS1159070629 (15:21636906 G>C,T), RS1159226819 (15:21637778 A>G), RS1160012420 (15:21638291 T>C), RS1160854837 (15:21639370 T>G), RS1160960217 (15:21636454 G>A,C), RS1161020035 (15:21637453 G>A), RS1161612296 (15:21637787 A>G), RS1161735661 (15:21638791 G>A,T), RS1162894869 (15:21637019 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.