OR4N2

Summary

OR4N2 (olfactory receptor family 4 subfamily N member 2, HGNC:14742) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4N2 (Q8NGD1). Odorant receptor. It is a selective cancer dependency (DepMap: 14.0% of cell lines).

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a seven-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390429 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 58 total
• Cancer dependency (DepMap): dependent in 14.0% of screened cell lines
• MANE Select transcript: NM_001004723

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14742
Approved symbol	OR4N2
Name	olfactory receptor family 4 subfamily N member 2
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176294
Ensembl biotype	protein_coding
Entrez	390429

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000315947, ENST00000557414, ENST00000557677, ENST00000641240

RefSeq mRNA: 1 — MANE Select: NM_001004723 NM_001004723

CCDS: CCDS32022

Canonical transcript exons

ENST00000557677 — 2 exons

Exon	Start	End
ENSE00002512123	19803770	19803844
ENSE00003901902	19827440	19830253

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 80.60.

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.27	gold quality
testis	UBERON:0000473	50.03	gold quality
left testis	UBERON:0004533	49.10	gold quality
right testis	UBERON:0004534	44.66	gold quality
lower esophagus mucosa	UBERON:0035834	39.16	gold quality
monocyte	CL:0000576	37.71	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
leukocyte	CL:0000738	36.80	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
islet of Langerhans	UBERON:0000006	36.10	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
prefrontal cortex	UBERON:0000451	32.93	gold quality
primary visual cortex	UBERON:0002436	32.85	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
superior frontal gyrus	UBERON:0002661	29.91	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
omental fat pad	UBERON:0010414	29.75	gold quality
liver	UBERON:0002107	29.16	gold quality
frontal cortex	UBERON:0001870	28.64	gold quality
corpus callosum	UBERON:0002336	28.54	gold quality
Brodmann (1909) area 9	UBERON:0013540	28.45	silver quality
duodenum	UBERON:0002114	28.14	gold quality
pancreas	UBERON:0001264	27.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.58

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 14.0% of screened cell lines.

Cross-species orthologs

0 orthologs

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4N2 — Q8NGD1 (reviewed: Q8NGD1)

Alternative names: Olfactory receptor OR14-13, Olfactory receptor OR14-8

All UniProt accessions (3): A0A126GVT2, Q8NGD1, G3V3W5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004723* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGD1-F1	87.56	0.49

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, MANNO_MIDBRAIN_NEUROTYPES_HDA, DESCARTES_MAIN_FETAL_ENS_GLIA, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

182 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4N2	ITPRID1	Q6ZRS4	445
OR4N2	OR11H2	Q8NH07	414
OR4N2	OR4Q3	Q8NH05	390
OR4N2	OR4M1	Q8NGD0	388
OR4N2	POTEM	A6NI47	380
OR4N2	TTC29	Q8NA56	348
OR4N2	TAS2R4	Q9NYW5	331
OR4N2	TAS2R46	P59540	302
OR4N2	CCDC91	Q7Z6B0	299
OR4N2	ZNF568	Q3ZCX4	297
OR4N2	OR4K2	Q8NGD2	276
OR4N2	OR4K1	Q8NGD4	276
OR4N2	PGLYRP4	Q96LB8	275
OR4N2	PSG6	Q00889	248
OR4N2	NLRP14	Q86W24	247

IntAct

3 interactions, top by confidence:

A	B	Type	Score
OR4N2	S100A10	psi-mi:“MI:0915”(physical association)	0.400
OR4N2	EMC8	psi-mi:“MI:0914”(association)	0.350

BioGRID (28): OR4N2 (Proximity Label-MS), SLC12A9 (Affinity Capture-MS), EMC8 (Affinity Capture-MS), SARAF (Affinity Capture-MS), SLC7A3 (Affinity Capture-MS), EMC1 (Affinity Capture-MS), SLC4A2 (Affinity Capture-MS), PIGO (Affinity Capture-MS), TMEM259 (Affinity Capture-MS), SLC5A3 (Affinity Capture-MS), SLC12A7 (Affinity Capture-MS), CLCN3 (Affinity Capture-MS), UBB (Affinity Capture-MS), EMC7 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

604 predictions. Top by Δscore:

Variant	Effect	Δscore
14:19747796:GT:G	donor_loss	0.9700
14:19747797:T:A	donor_loss	0.9700
14:19747500:C:G	donor_gain	0.9600
14:19827719:A:G	donor_gain	0.9100
14:19747796:G:GG	donor_gain	0.8800
14:19827735:G:GT	donor_gain	0.8800
14:19747490:G:GT	donor_gain	0.8600
14:19747791:GACAG:G	donor_gain	0.8500
14:19827715:G:GT	donor_gain	0.8100
14:19827871:C:G	donor_gain	0.7900
14:19827928:G:GA	donor_gain	0.7900
14:19748256:ACAGT:A	acceptor_gain	0.7800
14:19827880:G:GT	donor_gain	0.7800
14:19827927:T:TA	donor_gain	0.7800
14:19747763:G:GT	donor_gain	0.7600
14:19827996:A:AG	acceptor_gain	0.7600
14:19827997:G:GG	acceptor_gain	0.7600
14:19748028:A:AG	donor_gain	0.7500
14:19780444:G:GT	donor_gain	0.7500
14:19827774:G:GT	donor_gain	0.7500
14:19748095:T:TA	acceptor_gain	0.7300
14:19827535:GCT:G	donor_gain	0.7200
14:19827778:G:T	donor_gain	0.7000
14:19827513:A:G	donor_gain	0.6900
14:19827636:T:TA	acceptor_gain	0.6800
14:19827993:CACA:C	acceptor_loss	0.6800
14:19827995:CA:C	acceptor_loss	0.6800
14:19780386:G:GT	donor_gain	0.6600
14:19827736:C:G	donor_gain	0.6500
14:19827997:GGTC:G	acceptor_gain	0.6500

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000034880 (14:19803564 C>G,T), RS1000086725 (14:19803119 AG>A), RS1000477785 (14:19813628 T>C,G), RS1000511080 (14:19823426 C>T), RS1001082421 (14:19811200 C>A), RS1001193181 (14:19813036 A>G,T), RS1001299366 (14:19811938 A>G), RS1001413606 (14:19812591 T>C,G), RS1001482426 (14:19809346 A>C,T), RS1001803277 (14:19824985 G>A), RS1002200372 (14:19810770 C>T), RS1002364671 (14:19821999 T>A), RS1002411355 (14:19822455 T>C), RS1002423192 (14:19810429 G>A), RS1002898549 (14:19830584 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.