OR4N4C

Summary

OR4N4C (olfactory receptor family 4 subfamily N member 4C, HGNC:55110) is a protein-coding gene on chromosome 15q11.2, encoding Olfactory receptor 4N4C (A0A096LPK9). Odorant receptor.

Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 105369274 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001365389

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55110
Approved symbol	OR4N4C
Name	olfactory receptor family 4 subfamily N member 4C
Location	15q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000279408
Ensembl biotype	protein_coding
Entrez	105369274

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000623441

RefSeq mRNA: 1 — MANE Select: NM_001365389 NM_001365389

CCDS: CCDS91961

Canonical transcript exons

ENST00000623441 — 1 exons

Exon	Start	End
ENSE00003760045	21651844	21652968

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 88.16.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.16	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.47	gold quality
left testis	UBERON:0004533	48.60	gold quality
testis	UBERON:0000473	47.70	gold quality
right testis	UBERON:0004534	43.31	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	34.95	gold quality
muscle tissue	UBERON:0002385	32.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.38	gold quality
liver	UBERON:0002107	28.32	gold quality
duodenum	UBERON:0002114	28.14	gold quality
urinary bladder	UBERON:0001255	28.00	gold quality
lymph node	UBERON:0000029	27.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	27.56	gold quality
superior frontal gyrus	UBERON:0002661	27.16	gold quality
tonsil	UBERON:0002372	27.05	gold quality
muscle of leg	UBERON:0001383	26.60	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.33	gold quality
leukocyte	CL:0000738	26.04	gold quality
gall bladder	UBERON:0002110	25.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4n4b	ENSMUSG00000090874
mus_musculus	Or4n4	ENSMUSG00000091873
rattus_norvegicus	Or4n4	ENSRNOG00000047419
rattus_norvegicus	Or4n4	ENSRNOG00000077425

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4N4C — A0A096LPK9 (reviewed: A0A096LPK9)

All UniProt accessions (1): A0A096LPK9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001352318* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (17 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A096LPK9-F1	84.93	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr15q11

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

40 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4N4C	ZNF317	Q96PQ6	507
OR4N4C	ATMIN	O43313	320
OR4N4C	PDE1A	P54750	248
OR4N4C	PTPRT	O14522	223
OR4N4C	NFATC3	Q12968	167
OR4N4C	TAS2R1	Q9NYW7	159
OR4N4C	HAUS3	Q68CZ6	73
OR4N4C	ARRB2	P32121	56
OR4N4C	ARRB1	P49407	56
OR4N4C	GNAL	P38405	54
OR4N4C	GNAS	Q5JWF2	54
OR4N4C	PRKACA	P17612	42
OR4N4C	GRK2	P25098	42
OR4N4C	GRK3	P35626	42
OR4N4C	PRKACB	P22694	42
OR4N4C	PRKACG	P22612	42

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2084 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:21651968:T:C	F12L	0.866
15:21651970:T:A	F12L	0.866
15:21651970:T:G	F12L	0.866
15:21652436:T:C	F168L	0.847
15:21652438:T:A	F168L	0.847
15:21652438:T:G	F168L	0.847
15:21652463:T:C	F177L	0.784
15:21652465:C:A	F177L	0.784
15:21652465:C:G	F177L	0.784
15:21652685:T:C	F251L	0.752
15:21652687:T:A	F251L	0.752
15:21652687:T:G	F251L	0.752
15:21652238:T:C	F102L	0.741
15:21652240:T:A	F102L	0.741
15:21652240:T:G	F102L	0.741
15:21652718:T:C	F262L	0.716
15:21652720:C:A	F262L	0.716
15:21652720:C:G	F262L	0.716
15:21652466:T:C	F178L	0.707
15:21652468:C:A	F178L	0.707
15:21652468:C:G	F178L	0.707
15:21652016:T:C	F28L	0.706
15:21652018:T:A	F28L	0.706
15:21652018:T:G	F28L	0.706
15:21651969:T:C	F12S	0.684
15:21652565:T:C	F211L	0.657
15:21652567:T:A	F211L	0.657
15:21652567:T:G	F211L	0.657
15:21652769:T:C	F279L	0.638
15:21652771:T:A	F279L	0.638

dbSNP variants (sampled 300 via entrez): RS1157556971 (15:21653357 T>G), RS1157576207 (15:21652317 G>A,T), RS1159079896 (15:21652931 C>A,G,T), RS1159794775 (15:21651932 G>A), RS1160876106 (15:21653400 ATAAG>A), RS1161840858 (15:21650292 T>A,C,G), RS1162623432 (15:21652040 C>T), RS1162752295 (15:21653031 T>C), RS1163834089 (15:21653409 A>ATATT), RS1164667590 (15:21652532 G>A,T), RS1165692911 (15:21653151 T>C), RS1166150950 (15:21650355 C>G), RS1166522769 (15:21652140 T>C), RS1166950827 (15:21652661 C>G,T), RS1168397675 (15:21650473 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.