OR4N5

Summary

OR4N5 (olfactory receptor family 4 subfamily N member 5, HGNC:15358) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4N5 (Q8IXE1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390437 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 60 total
• MANE Select transcript: NM_001004724

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15358
Approved symbol	OR4N5
Name	olfactory receptor family 4 subfamily N member 5
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000184394
Ensembl biotype	protein_coding
Entrez	390437

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641086

RefSeq mRNA: 1 — MANE Select: NM_001004724 NM_001004724

CCDS: CCDS32031

Canonical transcript exons

ENST00000641086 — 3 exons

Exon	Start	End
ENSE00003811837	20140843	20141211
ENSE00003812158	20143725	20145471
ENSE00003812535	20138820	20138890

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 81.32.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.32	gold quality
sural nerve	UBERON:0015488	38.49	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.73	gold quality
leukocyte	CL:0000738	29.54	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	29.02	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	27.34	gold quality
tonsil	UBERON:0002372	27.05	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
calcaneal tendon	UBERON:0003701	25.34	gold quality
muscle of leg	UBERON:0001383	25.08	gold quality
right lobe of liver	UBERON:0001114	24.89	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
pancreas	UBERON:0001264	24.54	gold quality
myometrium	UBERON:0001296	24.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4n5	ENSMUSG00000048933
rattus_norvegicus	Or4n5	ENSRNOG00000079422

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4N5 — Q8IXE1 (reviewed: Q8IXE1)

Alternative names: Olfactory receptor OR14-33

All UniProt accessions (2): A0A126GVN4, Q8IXE1

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004724* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 4, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IXE1-F1	88.04	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZNF407_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

234 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4N5	IZUMO2	Q6UXV1	525
OR4N5	BTBD17	A6NE02	511
OR4N5	FBRSL1	Q9HCM7	492
OR4N5	TAS2R1	Q9NYW7	470
OR4N5	MTX3	Q5HYI7	450
OR4N5	ZNF473	Q8WTR7	450
OR4N5	PCDHGA2	Q9Y5H1	447
OR4N5	TOP6BL	Q8N6T0	446
OR4N5	PCDHGA3	Q9Y5H0	444
OR4N5	CCDC85A	Q96PX6	442
OR4N5	OC90	Q02509	424
OR4N5	KLHL4	Q9C0H6	423
OR4N5	PCDHGA1	Q9Y5H4	418
OR4N5	FBRS	Q9HAH7	417
OR4N5	FAM133A	Q8N9E0	405

IntAct

2 interactions, top by confidence:

A	B	Type	Score
PDIA4	OR4N5	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): OR4N5 (Proximity Label-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

60 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

118 predictions. Top by Δscore:

Variant	Effect	Δscore
14:20144158:C:G	donor_gain	0.9600
14:20144002:GAAG:G	donor_gain	0.9300
14:20143822:GCT:G	donor_gain	0.9000
14:20144002:GAAGG:G	donor_loss	0.9000
14:20144003:A:T	donor_gain	0.9000
14:20144003:AAG:A	donor_loss	0.9000
14:20144004:AGG:A	donor_loss	0.9000
14:20144005:GGTA:G	donor_loss	0.9000
14:20144006:G:GC	donor_loss	0.9000
14:20144007:T:G	donor_loss	0.9000
14:20144280:CACAG:C	acceptor_loss	0.9000
14:20144282:CAGGT:C	acceptor_loss	0.9000
14:20144283:A:AT	acceptor_loss	0.9000
14:20144208:TAC:T	donor_gain	0.8800
14:20144209:ACA:A	donor_gain	0.8800
14:20144283:A:AG	acceptor_gain	0.8600
14:20144284:G:GG	acceptor_gain	0.8600
14:20143975:G:GT	donor_gain	0.8300
14:20144002:G:GT	donor_gain	0.8000
14:20144275:T:TA	acceptor_gain	0.7900
14:20144283:AG:A	acceptor_gain	0.7600
14:20144284:GG:G	acceptor_gain	0.7600
14:20144119:GCCTT:G	donor_gain	0.7400
14:20144157:GC:G	donor_gain	0.7300
14:20144282:C:G	acceptor_gain	0.7300
14:20144284:GGTC:G	acceptor_gain	0.7300
14:20144284:GGT:G	acceptor_gain	0.7100
14:20144158:C:CG	donor_gain	0.7000
14:20144176:T:A	donor_gain	0.7000
14:20144281:A:AG	acceptor_gain	0.7000

AlphaMissense

2029 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:20144237:T:C	F168L	0.870
14:20144239:C:A	F168L	0.870
14:20144239:C:G	F168L	0.870
14:20143769:T:C	F12L	0.860
14:20143771:C:A	F12L	0.860
14:20143771:C:G	F12L	0.860
14:20144486:T:C	F251L	0.859
14:20144488:T:A	F251L	0.859
14:20144488:T:G	F251L	0.859
14:20144264:T:C	F177L	0.780
14:20144266:C:A	F177L	0.780
14:20144266:C:G	F177L	0.780
14:20144267:T:C	F178L	0.757
14:20144269:C:A	F178L	0.757
14:20144269:C:G	F178L	0.757
14:20143861:T:A	N42K	0.753
14:20143861:T:G	N42K	0.753
14:20143770:T:C	F12S	0.747
14:20144039:T:C	F102L	0.740
14:20144041:T:A	F102L	0.740
14:20144041:T:G	F102L	0.740
14:20144519:T:C	F262L	0.739
14:20144521:C:A	F262L	0.739
14:20144521:C:G	F262L	0.739
14:20144354:A:C	S207R	0.726
14:20144356:C:A	S207R	0.726
14:20144356:C:G	S207R	0.726
14:20144089:G:A	M118I	0.704
14:20144089:G:C	M118I	0.704
14:20144089:G:T	M118I	0.704

dbSNP variants (sampled 300 via entrez): RS1000131453 (14:20143018 G>C), RS1000487856 (14:20139028 G>A), RS1001075950 (14:20138324 C>A,G,T), RS1001095470 (14:20137748 G>A), RS1001293512 (14:20138964 G>A,C,T), RS1001343109 (14:20138601 G>C), RS1002083401 (14:20145144 G>A,T), RS1002134419 (14:20145473 A>G,T), RS1002267156 (14:20137407 G>C), RS1002417486 (14:20142889 C>A), RS1002485723 (14:20139647 C>T), RS1003083279 (14:20140860 T>C), RS1003424048 (14:20141890 A>G), RS1003732517 (14:20136996 T>C), RS1004889994 (14:20143649 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.