OR4Q3

Summary

OR4Q3 (olfactory receptor family 4 subfamily Q member 3, HGNC:15426) is a protein-coding gene on chromosome 14q11.2, encoding Olfactory receptor 4Q3 (Q8NH05). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 441669 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 79 total
• MANE Select transcript: NM_001405963

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15426
Approved symbol	OR4Q3
Name	olfactory receptor family 4 subfamily Q member 3
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	C14orf13
Ensembl gene	ENSG00000182652
Ensembl biotype	protein_coding
Entrez	441669

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000642117

RefSeq mRNA: 1 — MANE Select: NM_001405963 NM_001405963

Canonical transcript exons

ENST00000642117 — 2 exons

Exon	Start	End
ENSE00003811970	19747406	19749469
ENSE00003813981	19743571	19743671

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 37.20.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	37.20	gold quality
sural nerve	UBERON:0015488	36.79	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.53	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
monocyte	CL:0000576	34.43	gold quality
leukocyte	CL:0000738	34.40	gold quality
bone marrow	UBERON:0002371	34.12	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
right ovary	UBERON:0002118	30.42	gold quality
primary visual cortex	UBERON:0002436	30.25	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
cerebellum	UBERON:0002037	29.66	gold quality
urinary bladder	UBERON:0001255	29.63	gold quality
liver	UBERON:0002107	29.61	gold quality
right hemisphere of cerebellum	UBERON:0014890	29.59	gold quality
cerebellar cortex	UBERON:0002129	29.54	gold quality
cerebellar hemisphere	UBERON:0002245	29.49	gold quality
prefrontal cortex	UBERON:0000451	29.35	gold quality
vermiform appendix	UBERON:0001154	29.33	gold quality
right uterine tube	UBERON:0001302	28.97	gold quality
tonsil	UBERON:0002372	28.70	gold quality
blood	UBERON:0000178	28.39	gold quality
duodenum	UBERON:0002114	28.14	gold quality
ovary	UBERON:0000992	27.90	gold quality
muscle of leg	UBERON:0001383	27.69	gold quality
lymph node	UBERON:0000029	27.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or4q3	ENSMUSG00000046210
rattus_norvegicus	AC122990.1	ENSRNOG00000033642

Paralogs (130): OR1I1 (ENSG00000094661), OR12D3 (ENSG00000112462), OR7A10 (ENSG00000127515), OR7C2 (ENSG00000127529), OR7C1 (ENSG00000127530), OR1E2 (ENSG00000127780), OR1J1 (ENSG00000136834), OR1L4 (ENSG00000136939), OR4D1 (ENSG00000141194), OR4K1 (ENSG00000155249), OR3A3 (ENSG00000159961), OR7G1 (ENSG00000161807), OR1Q1 (ENSG00000165202), OR1K1 (ENSG00000165204), OR4K2 (ENSG00000165762), OR4D6 (ENSG00000166884), OR1F1 (ENSG00000168124), OR4K14 (ENSG00000169484), OR4K15 (ENSG00000169488), OR7G3 (ENSG00000170920), OR7G2 (ENSG00000170923), OR1M1 (ENSG00000170929), OR4D5 (ENSG00000171014), OR1L6 (ENSG00000171459), OR1L3 (ENSG00000171481), OR1L8 (ENSG00000171496), OR1N2 (ENSG00000171501), OR1N1 (ENSG00000171505), OR2AT4 (ENSG00000171561), OR1A1 (ENSG00000172146), OR1A2 (ENSG00000172150), OR4C11 (ENSG00000172188), OR4X2 (ENSG00000172208), OR4D9 (ENSG00000172742), OR10K1 (ENSG00000173285), OR1L1 (ENSG00000173679), OR7D4 (ENSG00000174667), OR4S2 (ENSG00000174982), OR4B1 (ENSG00000175619), OR4D11 (ENSG00000176200)

Protein

Protein identifiers

Olfactory receptor 4Q3 — Q8NH05 (reviewed: Q8NH05)

Alternative names: Olfactory receptor 4Q4, Olfactory receptor OR14-3

All UniProt accessions (1): A0A2U3TZU4

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001392892* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050427	Olfactory_Receptors	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH05-F1	87.95	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 98–190

Glycosylation sites (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_DN, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY

GO Biological Process (4): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

324 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR4Q3	STAG2	Q8N3U4	506
OR4Q3	POTEM	A6NI47	447
OR4Q3	SMAP1	Q8IYB5	410
OR4Q3	OR4M1	Q8NGD0	390
OR4Q3	OR4N2	Q8NGD1	390
OR4Q3	OR4K2	Q8NGD2	380
OR4Q3	FAM47A	Q5JRC9	376
OR4Q3	Q12799	Q12799	353
OR4Q3	POTEG	Q6S5H5	350
OR4Q3	ZNF621	Q6ZSS3	348
OR4Q3	UBE3B	Q7Z3V4	310
OR4Q3	LPIN3	Q9BQK8	289
OR4Q3	HSF2BP	O75031	276
OR4Q3	GPATCH3	Q96I76	273
OR4Q3	OR4K5	Q8NGD3	271

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR4Q3	TMEM179B	psi-mi:“MI:0914”(association)	0.350

BioGRID (2): RBM12 (Affinity Capture-MS), TMEM179B (Affinity Capture-MS)

ESM2 similar proteins: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, P0C604, P0C623, P0C645, P0DN82, P58180, P58182, Q15615, Q60881, Q6IF82, Q8IXE1, Q8N0Y3, Q8NGA8, Q8NGB4, Q8NGB6, Q8NGC2, Q8NGC3, Q8NGD0, Q8NGD1, Q8NGD2, Q8NGD5, Q8NGE8, Q8NGF4, Q8NGF8, Q8NGF9, Q8NGI4, Q8NGI6, Q8NGJ0, Q8NGJ1, Q8NGL6, Q8NGM1, Q8NGN0, Q8NGN8, Q8NGX5, Q8NH05, Q8NH42, Q8NH49

Diamond homologs: A0A096LPK9, A0A0X1KG70, A6NHA9, A6NMZ5, O60412, O76099, O95013, P0C604, P0C623, P0C645, P0DN82, P23270, P23275, P58173, P58180, P58182, Q15615, Q60878, Q60881, Q60888, Q6IEV9, Q6IEY1, Q6IF82, Q7TQQ0, Q8IXE1, Q8N0Y3, Q8N628, Q8NGA8, Q8NGB2, Q8NGB4, Q8NGB6, Q8NGB8, Q8NGB9, Q8NGC2, Q8NGC3, Q8NGC4, Q8NGC6, Q8NGD0, Q8NGD1, Q8NGD2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	72
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

181 predictions. Top by Δscore:

Variant	Effect	Δscore
14:19747796:GT:G	donor_loss	0.9700
14:19747797:T:A	donor_loss	0.9700
14:19747500:C:G	donor_gain	0.9600
14:19747796:G:GG	donor_gain	0.8800
14:19747490:G:GT	donor_gain	0.8600
14:19747791:GACAG:G	donor_gain	0.8500
14:19748256:ACAGT:A	acceptor_gain	0.7800
14:19747763:G:GT	donor_gain	0.7600
14:19748028:A:AG	donor_gain	0.7500
14:19748095:T:TA	acceptor_gain	0.7300
14:19747758:A:AG	donor_gain	0.6300
14:19747759:G:GG	donor_gain	0.6300
14:19748257:C:G	acceptor_gain	0.6300
14:19748258:A:AG	acceptor_gain	0.6200
14:19748259:G:GG	acceptor_gain	0.6200
14:19747979:A:G	acceptor_gain	0.5900
14:19748065:T:A	acceptor_gain	0.5900
14:19748259:GT:G	acceptor_gain	0.5800
14:19747793:CAG:C	donor_gain	0.5700
14:19747903:TGCAG:T	acceptor_loss	0.5600
14:19747904:GCAG:G	acceptor_loss	0.5600
14:19747905:CAGGT:C	acceptor_loss	0.5600
14:19747906:A:AC	acceptor_loss	0.5600
14:19747937:T:TA	acceptor_gain	0.5500
14:19747568:AAC:A	donor_gain	0.5400
14:19747569:ACA:A	donor_gain	0.5400
14:19748171:C:A	donor_gain	0.5400
14:19747794:AG:A	donor_gain	0.5200
14:19747795:GG:G	donor_gain	0.5200
14:19748091:ATCCT:A	acceptor_gain	0.5100

AlphaMissense

2108 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:19748172:A:C	S249R	0.957
14:19748174:C:A	S249R	0.957
14:19748174:C:G	S249R	0.957
14:19747461:T:C	F12L	0.955
14:19747463:T:A	F12L	0.955
14:19747463:T:G	F12L	0.955
14:19747932:T:C	F169L	0.943
14:19747934:C:A	F169L	0.943
14:19747934:C:G	F169L	0.943
14:19748181:T:C	F252L	0.939
14:19748183:C:A	F252L	0.939
14:19748183:C:G	F252L	0.939
14:19747462:T:G	F12C	0.928
14:19747959:T:C	F178L	0.927
14:19747961:C:A	F178L	0.927
14:19747961:C:G	F178L	0.927
14:19747758:A:C	S111R	0.920
14:19747760:T:A	S111R	0.920
14:19747760:T:G	S111R	0.920
14:19747650:A:C	S75R	0.917
14:19747652:C:A	S75R	0.917
14:19747652:C:G	S75R	0.917
14:19747784:G:A	M119I	0.914
14:19747784:G:C	M119I	0.914
14:19747784:G:T	M119I	0.914
14:19747462:T:C	F12S	0.913
14:19748037:A:C	S204R	0.893
14:19748039:T:A	S204R	0.893
14:19748039:T:G	S204R	0.893
14:19747981:T:A	V185D	0.891

dbSNP variants (sampled 300 via entrez): RS1000568338 (14:19752409 C>G,T), RS1001466316 (14:19744134 G>A), RS1002131692 (14:19742991 A>C), RS1004539157 (14:19744506 C>T), RS1004656191 (14:19752500 C>T), RS1009728923 (14:19743073 G>T), RS1010072612 (14:19743587 T>A,C), RS10133422 (14:19752802 G>A,C), RS10145068 (14:19744476 G>A), RS1016176090 (14:19752502 C>A), RS1017834475 (14:19743209 G>A,C,T), RS1021230049 (14:19742813 T>C), RS1021531846 (14:19743076 T>G), RS1029995709 (14:19743716 T>C), RS1030467504 (14:19752485 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Grape Seed Proanthocyanidins	decreases expression, affects cotreatment	1
Acetaminophen	increases expression	1
Arsenicals	increases methylation	1
Cadmium	decreases expression	1
Catechin	affects cotreatment, decreases expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.