OR51A7

Summary

OR51A7 (olfactory receptor family 51 subfamily A member 7, HGNC:15188) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51A7 (Q8NH64). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 119687 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001004749

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15188
Approved symbol	OR51A7
Name	olfactory receptor family 51 subfamily A member 7
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176895
Ensembl biotype	protein_coding
Entrez	119687

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000359350, ENST00000641490

RefSeq mRNA: 1 — MANE Select: NM_001004749 NM_001004749

CCDS: CCDS31364

Canonical transcript exons

ENST00000641490 — 2 exons

Exon	Start	End
ENSE00003812388	4907339	4909462
ENSE00003813487	4903783	4903844

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 40.59.

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	40.59	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
duodenum	UBERON:0002114	32.60	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
leukocyte	CL:0000738	31.68	gold quality
monocyte	CL:0000576	31.32	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
liver	UBERON:0002107	28.04	gold quality
adrenal tissue	UBERON:0018303	27.73	gold quality
lymph node	UBERON:0000029	27.57	gold quality
superior frontal gyrus	UBERON:0002661	27.26	gold quality
tonsil	UBERON:0002372	27.05	gold quality
urinary bladder	UBERON:0001255	26.79	gold quality
blood	UBERON:0000178	26.73	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.05	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.28

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51a7	ENSMUSG00000073962
rattus_norvegicus	Or51a7b	ENSRNOG00000015649
rattus_norvegicus	Or51a7	ENSRNOG00000034083

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51A7 — Q8NH64 (reviewed: Q8NH64)

Alternative names: Olfactory receptor OR11-27

All UniProt accessions (1): Q8NH64

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004749* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, sequence variant 3, glycosylation site 2, chain 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH64-F1	90.03	0.75

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–189

Glycosylation sites (2): 5, 192

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 19 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

262 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51A7	VN1R4	Q7Z5H5	475
OR51A7	TAS2R4	Q9NYW5	451
OR51A7	VN1R2	Q8NFZ6	437
OR51A7	OAZ2	O95190	376
OR51A7	VN1R1	Q9GZP7	374
OR51A7	TAS2R13	Q9NYV9	349
OR51A7	CFAP52	Q8N1V2	336
OR51A7	MB21D2	Q8IYB1	332
OR51A7	ANO2	Q9NQ90	325
OR51A7	THUMPD1	Q9NXG2	325
OR51A7	DNAJC17	Q9NVM6	324
OR51A7	GNG7	O60262	321
OR51A7	AMER2	Q8N7J2	321
OR51A7	ASTE1	Q2TB18	320
OR51A7	CNGA2	Q16280	316

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

287 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4904766:G:GT	donor_gain	0.9600
11:4904684:GT:G	donor_gain	0.9100
11:4908068:GCT:G	donor_gain	0.9000
11:4904776:C:G	donor_gain	0.8800
11:4904691:A:T	donor_gain	0.8500
11:4908075:GCCC:G	donor_gain	0.8100
11:4904685:T:G	donor_gain	0.7800
11:4904690:G:GT	donor_gain	0.7700
11:4907709:G:GG	donor_gain	0.7700
11:4904686:G:GG	donor_gain	0.7600
11:4904712:A:G	donor_gain	0.7400
11:4907708:A:AG	donor_gain	0.7300
11:4908281:G:T	donor_gain	0.7300
11:4907391:G:GT	donor_gain	0.7100
11:4909253:T:G	acceptor_gain	0.6900
11:4907762:A:G	donor_gain	0.6800
11:4904770:A:T	donor_gain	0.6700
11:4908281:G:GT	donor_gain	0.6700
11:4907914:AG:A	acceptor_gain	0.6600
11:4907915:GG:G	acceptor_gain	0.6600
11:4907712:C:CG	donor_gain	0.6400
11:4907911:ATCAG:A	acceptor_gain	0.6400
11:4907757:T:G	donor_gain	0.6300
11:4907914:A:AG	acceptor_gain	0.6300
11:4907915:G:GG	acceptor_gain	0.6300
11:4908293:T:G	donor_gain	0.6300
11:4907425:G:GT	donor_gain	0.6200
11:4904773:GTGC:G	donor_gain	0.6100
11:4904774:TGCT:T	donor_gain	0.6100
11:4907470:T:G	donor_gain	0.5900

AlphaMissense

2064 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4907673:T:C	F102L	0.862
11:4907675:C:A	F102L	0.862
11:4907675:C:G	F102L	0.862
11:4908117:T:C	F250L	0.820
11:4908119:C:A	F250L	0.820
11:4908119:C:G	F250L	0.820
11:4907688:T:C	F107L	0.787
11:4907690:C:A	F107L	0.787
11:4907690:C:G	F107L	0.787
11:4907403:T:C	F12L	0.781
11:4907405:C:A	F12L	0.781
11:4907405:C:G	F12L	0.781
11:4907736:T:C	F123L	0.755
11:4907738:T:A	F123L	0.755
11:4907738:T:G	F123L	0.755
11:4907622:T:C	F85L	0.752
11:4907624:C:A	F85L	0.752
11:4907624:C:G	F85L	0.752
11:4907823:A:C	S152R	0.751
11:4907825:C:A	S152R	0.751
11:4907825:C:G	S152R	0.751
11:4908204:T:C	F279L	0.706
11:4908206:C:A	F279L	0.706
11:4908206:C:G	F279L	0.706
11:4907495:C:A	N42K	0.702
11:4907495:C:G	N42K	0.702
11:4907553:T:C	F62L	0.692
11:4907555:C:A	F62L	0.692
11:4907555:C:G	F62L	0.692
11:4907661:T:C	F98L	0.678

dbSNP variants (sampled 300 via entrez): RS1000365781 (11:4906026 T>C,G), RS1000863775 (11:4905709 A>G), RS1001508307 (11:4908947 G>A), RS1001683604 (11:4905085 A>G), RS1002016349 (11:4903384 C>G,T), RS1002569248 (11:4909142 TA>T,TAA), RS1002684695 (11:4903657 T>A), RS1002792804 (11:4909695 A>G), RS1003043663 (11:4906285 T>C), RS1004210921 (11:4908320 A>G,T), RS1004487439 (11:4903567 A>G,T), RS1004683153 (11:4909016 G>T), RS1005492941 (11:4902074 A>G), RS1006005638 (11:4905667 T>C), RS1006276151 (11:4906875 G>A,C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, increases methylation	2
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.