OR51B4

Summary

OR51B4 (olfactory receptor family 51 subfamily B member 4, HGNC:14708) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51B4 (Q9Y5P0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 79339 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• MANE Select transcript: NM_033179

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14708
Approved symbol	OR51B4
Name	olfactory receptor family 51 subfamily B member 4
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000183251
Ensembl biotype	protein_coding
Entrez	79339

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000380224

RefSeq mRNA: 1 — MANE Select: NM_033179 NM_033179

CCDS: CCDS7757

Canonical transcript exons

ENST00000380224 — 1 exons

Exon	Start	End
ENSE00001484148	5301014	5301946

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 56.41.

Top tissues by expression

197 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.41	gold quality
skin of hip	UBERON:0001554	46.74	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
sural nerve	UBERON:0015488	43.12	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
right ovary	UBERON:0002118	40.54	gold quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
ovary	UBERON:0000992	40.19	silver quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
oviduct epithelium	UBERON:0004804	40.03	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
left ovary	UBERON:0002119	39.95	silver quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
deltoid	UBERON:0001476	39.83	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.31

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51b4	ENSMUSG00000058200
rattus_norvegicus	Or51b4b	ENSRNOG00000025163
rattus_norvegicus	Or51b4	ENSRNOG00000069104

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51B4 — Q9Y5P0 (reviewed: Q9Y5P0)

Alternative names: Odorant receptor HOR5’beta1

All UniProt accessions (1): Q9Y5P0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_149419* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5P0-F1	88.27	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 95–186

Glycosylation sites (1): 4

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 37 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE14769_UNSTIM_VS_20MIN_LPS_BMDM_UP, GSE17721_LPS_VS_PAM3CSK4_1H_BMDC_UP

GO Biological Process (6): sensory perception of smell (GO:0007608), cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of chemical stimulus	1
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

326 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51B4	WFDC6	Q9BQY6	396
OR51B4	A0A0J9YYA3	A0A0J9YYA3	326
OR51B4	SSC4D	Q8WTU2	324
OR51B4	HBG1	P02096	322
OR51B4	ZNF454	Q8N9F8	308
OR51B4	ZNF540	Q8NDQ6	301
OR51B4	EIF4E1B	A6NMX2	296
OR51B4	HYLS1	Q96M11	295
OR51B4	KRTAP13-1	Q8IUC0	294
OR51B4	ZNF791	Q3KP31	290
OR51B4	HBB	P02023	281
OR51B4	TAS2R1	Q9NYW7	281
OR51B4	MRPS11	P82912	269
OR51B4	WFDC5	Q8TCV5	265
OR51B4	KLK9	Q9UKQ9	259

IntAct

0 interactions, top by confidence:

BioGRID (1): OR51B4 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

213 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5301682:C:CA	donor_gain	0.7600
11:5301295:T:TC	acceptor_gain	0.6900
11:5301288:T:C	acceptor_gain	0.6500
11:5301300:A:C	acceptor_gain	0.6500
11:5301614:G:C	donor_gain	0.5900
11:5301615:ATAC:A	donor_loss	0.5900
11:5301616:TACCT:T	donor_loss	0.5900
11:5301617:AC:A	donor_loss	0.5900
11:5301618:C:CC	donor_loss	0.5900
11:5301298:G:C	acceptor_gain	0.5800
11:5301300:A:AC	acceptor_gain	0.5800
11:5301619:C:G	donor_loss	0.5700
11:5301736:T:TA	donor_gain	0.5700
11:5301298:G:GC	acceptor_gain	0.5600
11:5301772:A:AC	donor_gain	0.5600
11:5301941:C:CT	donor_gain	0.5500
11:5301448:CACAA:C	acceptor_gain	0.5400
11:5301777:A:C	donor_gain	0.5400
11:5301888:G:GA	donor_gain	0.5200
11:5301288:T:TC	acceptor_gain	0.5100
11:5301614:GATAC:G	donor_gain	0.5100
11:5301325:CAT:C	acceptor_gain	0.5000
11:5301302:A:C	acceptor_gain	0.4900
11:5301328:C:CC	acceptor_gain	0.4900
11:5301283:CTGT:C	acceptor_gain	0.4800
11:5301287:C:CC	acceptor_gain	0.4800
11:5301737:C:A	donor_gain	0.4600
11:5301463:A:T	acceptor_gain	0.4400
11:5301612:AAGAT:A	donor_gain	0.4400
11:5301613:AGATA:A	donor_gain	0.4400

AlphaMissense

2047 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5301422:A:C	F175L	0.785
11:5301422:A:T	F175L	0.785
11:5301424:A:G	F175L	0.785
11:5301917:G:C	F10L	0.732
11:5301917:G:T	F10L	0.732
11:5301919:A:G	F10L	0.732
11:5301647:G:C	F100L	0.695
11:5301647:G:T	F100L	0.695
11:5301649:A:G	F100L	0.695
11:5301203:A:C	F248L	0.685
11:5301203:A:T	F248L	0.685
11:5301205:A:G	F248L	0.685
11:5301164:A:C	F261L	0.674
11:5301164:A:T	F261L	0.674
11:5301166:A:G	F261L	0.674
11:5301659:G:C	F96L	0.671
11:5301659:G:T	F96L	0.671
11:5301661:A:G	F96L	0.671
11:5301902:G:C	F15L	0.622
11:5301902:G:T	F15L	0.622
11:5301904:A:G	F15L	0.622
11:5301587:G:C	F120L	0.612
11:5301587:G:T	F120L	0.612
11:5301589:A:G	F120L	0.612
11:5301374:A:C	F191L	0.570
11:5301374:A:T	F191L	0.570
11:5301376:A:G	F191L	0.570

dbSNP variants (sampled 300 via entrez): RS1006751164 (11:5300708 T>C), RS1006860024 (11:5302172 T>C), RS1006874857 (11:5302871 G>A), RS1006890898 (11:5302353 G>A,C), RS1007878587 (11:5300872 G>A,T), RS1010317605 (11:5302612 A>G,T), RS1011210955 (11:5303192 C>G,T), RS1011240092 (11:5303403 A>C), RS1012739128 (11:5302955 T>C), RS1014292640 (11:5303515 T>G), RS1015746610 (11:5303460 T>C), RS1016751780 (11:5302438 G>T), RS1017201895 (11:5303231 T>C), RS1018252220 (11:5302179 T>C), RS1018721516 (11:5302883 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST007006_9	Logical memory (delayed recall) in normal cognition	1.000000e-07
GCST007060_4	Response to SSRI (symptom remission)	4.000000e-07
GCST007061_10	Response to antidepressants (symptom remission)	2.000000e-07
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004874	memory performance
EFO:0005658	response to selective serotonin reuptake inhibitor

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
3,19-(2-bromobenzylidene)andrographolide	decreases response to substance, increases expression	1
kojic acid	decreases expression	1
ICG 001	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Air Pollutants	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	decreases expression	1
Formaldehyde	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	decreases methylation	1
Asbestos, Crocidolite	affects expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.