OR51C1

Summary

OR51C1 (olfactory receptor family 51 subfamily C member 1, HGNC:15191) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor OR51C1 (A0A3B3IT45). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 401661 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• MANE Select transcript: NM_001396051

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15191
Approved symbol	OR51C1
Name	olfactory receptor family 51 subfamily C member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	OST734
Ensembl gene	ENSG00000197674
Ensembl biotype	protein_coding
Entrez	401661

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641159

RefSeq mRNA: 1 — MANE Select: NM_001396051 NM_001396051

CCDS: CCDS91423

Canonical transcript exons

ENST00000641159 — 2 exons

Exon	Start	End
ENSE00003813977	4690423	4691687
ENSE00003978146	4697653	4697853

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 87.81.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0835 / max 48.2127, expressed in 25 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118334	0.0835	25

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.81	gold quality
popliteal artery	UBERON:0002250	47.22	gold quality
tibial artery	UBERON:0007610	47.20	gold quality
colonic epithelium	UBERON:0000397	46.09	gold quality
prostate gland	UBERON:0002367	45.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	39.51	gold quality
sural nerve	UBERON:0015488	38.51	gold quality
rectum	UBERON:0001052	38.20	silver quality
colon	UBERON:0001155	36.53	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
transverse colon	UBERON:0001157	35.21	gold quality
placenta	UBERON:0001987	35.08	silver quality
skeletal muscle tissue	UBERON:0001134	35.06	gold quality
right coronary artery	UBERON:0001625	34.89	gold quality
smooth muscle tissue	UBERON:0001135	34.38	silver quality
intestine	UBERON:0000160	33.41	gold quality
vermiform appendix	UBERON:0001154	32.66	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
myometrium	UBERON:0001296	32.09	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
left coronary artery	UBERON:0001626	31.50	gold quality
prefrontal cortex	UBERON:0000451	30.13	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
gall bladder	UBERON:0002110	28.71	gold quality
tonsil	UBERON:0002372	28.63	gold quality
muscle of leg	UBERON:0001383	28.33	gold quality
duodenum	UBERON:0002114	28.14	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.47

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51f23b	ENSMUSG00000110008

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor OR51C1 — A0A3B3IT45 (reviewed: A0A3B3IT45)

All UniProt accessions (1): A0A3B3IT45

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001382980* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A0A3B3IT45-F1	87.55	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 97–179

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 15 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11p15, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

110 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51C1	CNGA2	Q16280	385
OR51C1	GLYATL3	Q5SZD4	374
OR51C1	SLC25A35	Q3KQZ1	325
OR51C1	LCN10	Q6JVE6	314
OR51C1	LCN15	Q6UWW0	311
OR51C1	ANO2	Q9NQ90	306
OR51C1	OBP2B	Q9NPH6	304
OR51C1	SCGB1C1	Q8TD33	303
OR51C1	SCGB1C2	P0DMR2	303
OR51C1	GNAL	P38405	297
OR51C1	SPEF1	Q9Y4P9	273
OR51C1	SEC14L3	Q9UDX4	271
OR51C1	SVOPL	Q8N434	270
OR51C1	Q5T8A5	Q5T8A5	266
OR51C1	ADCY3	O60266	263

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

77 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4697651:A:AC	donor_gain	1.0000
11:4697652:C:CC	donor_gain	1.0000
11:4697652:CAGAG:C	donor_gain	1.0000
11:4697650:TACA:T	donor_loss	0.9900
11:4697651:ACAG:A	donor_loss	0.9900
11:4697652:C:CG	donor_loss	0.9900
11:4697652:CA:C	donor_gain	0.9900
11:4697652:CAG:C	donor_gain	0.9900
11:4697652:CAGA:C	donor_gain	0.9900
11:4697647:A:AC	donor_gain	0.9800
11:4697648:C:CC	donor_gain	0.9800
11:4697645:TTACT:T	donor_loss	0.9200
11:4697646:TACTT:T	donor_loss	0.9200
11:4697640:CAGTT:C	donor_gain	0.9000
11:4697648:CTTA:C	donor_gain	0.9000
11:4697757:ATT:A	donor_gain	0.8500
11:4697679:T:TA	donor_gain	0.8200
11:4691453:G:C	donor_gain	0.8000
11:4697649:T:C	donor_gain	0.8000
11:4690802:T:C	donor_gain	0.7500
11:4697651:A:G	donor_gain	0.6100
11:4694233:C:CT	acceptor_gain	0.5800
11:4691516:A:AC	donor_gain	0.5500
11:4697651:AC:A	donor_gain	0.5400
11:4697647:ACTT:A	donor_gain	0.5200
11:4691452:AG:A	donor_gain	0.5100
11:4691735:T:TG	acceptor_gain	0.5100
11:4697648:CTT:C	donor_gain	0.5100
11:4697650:TAC:T	donor_gain	0.5100
11:4697821:A:AC	donor_gain	0.5100

AlphaMissense

2058 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4691328:A:C	F123L	0.728
11:4691328:A:T	F123L	0.728
11:4691330:A:G	F123L	0.728
11:4690905:A:C	F264L	0.717
11:4690905:A:T	F264L	0.717
11:4690907:A:G	F264L	0.717
11:4691391:G:C	F102L	0.716
11:4691391:G:T	F102L	0.716
11:4691393:A:G	F102L	0.716
11:4691661:G:C	F12L	0.716
11:4691661:G:T	F12L	0.716
11:4691663:A:G	F12L	0.716
11:4691337:A:C	F120L	0.675
11:4691337:A:T	F120L	0.675
11:4691339:A:G	F120L	0.675
11:4691604:G:C	F31L	0.640
11:4691604:G:T	F31L	0.640
11:4691606:A:G	F31L	0.640
11:4691253:A:C	S148R	0.637
11:4691253:A:T	S148R	0.637
11:4691255:T:G	S148R	0.637
11:4690926:A:C	S257R	0.626
11:4690926:A:T	S257R	0.626
11:4690928:T:G	S257R	0.626
11:4691442:G:C	F85L	0.618
11:4691442:G:T	F85L	0.618
11:4691444:A:G	F85L	0.618
11:4691436:G:C	F87L	0.609
11:4691436:G:T	F87L	0.609
11:4691438:A:G	F87L	0.609

dbSNP variants (sampled 300 via entrez): RS1000253529 (11:4694152 C>T), RS1000537923 (11:4690408 G>A), RS1000677770 (11:4693749 G>A), RS1000817834 (11:4699346 A>G), RS1000939360 (11:4694016 T>C), RS1001265516 (11:4695548 A>T), RS1001472976 (11:4698070 G>A), RS1002128711 (11:4693627 A>C), RS1002318089 (11:4698827 A>T), RS1002693296 (11:4699147 G>A), RS1003182844 (11:4692590 C>T), RS1003716249 (11:4691598 G>A), RS1003852664 (11:4692794 A>G), RS1004480785 (11:4697232 T>A), RS1004684253 (11:4692296 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90026416_9	Mild age-related type 2 diabetes	3.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.