OR51E1

Summary

OR51E1 (olfactory receptor family 51 subfamily E member 1, HGNC:15194) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51E1 (Q8TCB6). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 143503 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_152430

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15194
Approved symbol	OR51E1
Name	olfactory receptor family 51 subfamily E member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	GPR136
Ensembl gene	ENSG00000180785
Ensembl biotype	protein_coding
OMIM	611267
Entrez	143503

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000396952, ENST00000530215

RefSeq mRNA: 1 — MANE Select: NM_152430 NM_152430

CCDS: CCDS31358

Canonical transcript exons

ENST00000396952 — 2 exons

Exon	Start	End
ENSE00001600443	4652488	4655488
ENSE00003845567	4643982	4644030

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 83.54.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4376 / max 443.0262, expressed in 73 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
112778	0.2540	55
112776	0.1407	19
112777	0.0429	14

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	83.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.18	gold quality
tibialis anterior	UBERON:0001385	78.04	silver quality
pancreatic ductal cell	CL:0002079	73.68	silver quality
apex of heart	UBERON:0002098	73.51	gold quality
ileal mucosa	UBERON:0000331	73.50	gold quality
popliteal artery	UBERON:0002250	71.35	gold quality
tibial artery	UBERON:0007610	71.30	gold quality
heart left ventricle	UBERON:0002084	69.20	gold quality
cardiac ventricle	UBERON:0002082	68.73	gold quality
left ventricle myocardium	UBERON:0006566	65.91	gold quality
placenta	UBERON:0001987	65.81	gold quality
prostate gland	UBERON:0002367	65.76	gold quality
adipose tissue of abdominal region	UBERON:0007808	64.96	gold quality
omental fat pad	UBERON:0010414	64.81	gold quality
peritoneum	UBERON:0002358	64.74	gold quality
right coronary artery	UBERON:0001625	64.60	gold quality
smooth muscle tissue	UBERON:0001135	64.04	gold quality
deltoid	UBERON:0001476	62.68	silver quality
hindlimb stylopod muscle	UBERON:0004252	62.36	gold quality
parietal pleura	UBERON:0002400	62.01	silver quality
heart	UBERON:0000948	61.89	gold quality
left coronary artery	UBERON:0001626	61.75	gold quality
coronary artery	UBERON:0001621	61.11	gold quality
adipose tissue	UBERON:0001013	60.95	gold quality
muscle of leg	UBERON:0001383	60.78	gold quality
colonic epithelium	UBERON:0000397	59.96	gold quality
gastrocnemius	UBERON:0001388	59.48	gold quality
rectum	UBERON:0001052	59.47	gold quality
vermiform appendix	UBERON:0001154	58.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

102 targeting OR51E1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-3143	99.93	71.96	3104
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-182-5P	99.87	74.03	2589

Literature-anchored findings (GeneRIF, showing 9)

• This publication uses ‘GPR136’ as a name for this gene. (PMID:12732197)
• Results suggest that PSGR2 may be useful as a tissue marker and molecular target for the early detection and treatment of human prostate cancers. (PMID:16206286)
• expression of PSGR and PSGR2 relative to AMACR in prostate cancer; AMACR was the most overexpressed, but in some cases expression of AMACR was not significantly elevated while PSGR and/or PSGR2 were substantially elevated (PMID:16491480)
• OR51E1 protein is a potential novel clinical tissue biomarker for small intestine neuroendocrine carcinomas. (PMID:23184910)
• Olfactory receptor 51E1 as a novel target for diagnosis in somatostatin receptor-negative lung carcinoids. (PMID:23969981)
• Results suggest the involvement of OR51E1 in growth processes of PCa cells and its impact on AR-mediated signaling. These findings provide novel evidences to support the functional importance of ORs in PCa pathogenesis. (PMID:27374083)
• These findings indicate that OR51E1 may play a role as metabolic regulator of cardiac function (PMID:28116519)
• Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line. (PMID:33640452)
• Effect of OR51E1 single nucleotide polymorphisms on glioma susceptibility in the Chinese Han population. (PMID:37207826)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51e1	ENSMUSG00000070423
rattus_norvegicus	Or51e1	ENSRNOG00000018551

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51E1 — Q8TCB6 (reviewed: Q8TCB6)

Alternative names: D-GPCR, G-protein coupled receptor 164, Olfactory receptor 52A3, Prostate-overexpressed G protein-coupled receptor, Prostate-specific G protein-coupled receptor 2

All UniProt accessions (3): A0A126GVF8, E9PKL6, Q8TCB6

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Tissue specificity. Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_689643* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (22 total): topological domain 8, transmembrane region 7, glycosylation site 2, sequence variant 2, chain 1, disulfide bond 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TCB6-F1	88.53	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 100–182

Glycosylation sites (2): 8, 91

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 64 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, MCCOLLUM_GELDANAMYCIN_RESISTANCE_DN, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, GSE10240_CTRL_VS_IL17_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_UP, MIR3662

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (4): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), protein binding (GO:0005515), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
binding	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

334 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51E1	AMACR	Q9UHK6	848
OR51E1	ADCY3	O60266	594
OR51E1	HCAR2	Q8TDS4	570
OR51E1	FFAR2	O15552	559
OR51E1	CNGA2	Q16280	545
OR51E1	FFAR3	O14843	478
OR51E1	RTP2	Q5QGT7	424
OR51E1	GNAL	P38405	423
OR51E1	GPR160	Q9UJ42	409
OR51E1	OMP	P47874	399
OR51E1	GPR142	Q7Z601	389
OR51E1	ADRB2	P07550	386
OR51E1	TAAR5	O14804	382
OR51E1	ADGRG4	Q8IZF6	370
OR51E1	PYY	P10082	367
OR51E1	CNGA4	Q8IV77	367

IntAct

5 interactions, top by confidence:

A	B	Type	Score
KCTD17	OR51E1	psi-mi:“MI:0915”(physical association)	0.560
OR51E1	KIAA1549	psi-mi:“MI:0915”(physical association)	0.400
KCTD17	OR51E1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (2): OR51E1 (Two-hybrid), KIAA1549 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	46
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

285 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4643614:A:AG	donor_gain	1.0000
11:4652482:TTCCA:T	acceptor_loss	0.9800
11:4652483:TCCA:T	acceptor_loss	0.9800
11:4652484:CCAG:C	acceptor_loss	0.9800
11:4652485:CAGCC:C	acceptor_loss	0.9800
11:4652486:A:C	acceptor_loss	0.9800
11:4652487:G:GC	acceptor_loss	0.9800
11:4652487:GCCT:G	acceptor_gain	0.9800
11:4643702:G:T	donor_gain	0.9700
11:4652486:A:AG	acceptor_gain	0.9700
11:4652487:G:GG	acceptor_gain	0.9700
11:4652487:GC:G	acceptor_gain	0.9700
11:4643614:A:G	donor_gain	0.9600
11:4652487:GCCTC:G	acceptor_gain	0.9600
11:4643601:G:GT	donor_gain	0.9500
11:4643863:G:GT	donor_gain	0.9500
11:4643518:TG:T	donor_gain	0.9300
11:4643519:GG:G	donor_gain	0.9300
11:4652487:GCC:G	acceptor_gain	0.9300
11:4652478:T:A	acceptor_loss	0.9200
11:4643519:G:GT	donor_gain	0.9100
11:4652481:ATTCC:A	acceptor_loss	0.9100
11:4643619:T:G	donor_gain	0.9000
11:4644026:TTG:T	donor_gain	0.8800
11:4644001:G:GT	donor_gain	0.8600
11:4643597:TCACG:T	donor_gain	0.8500
11:4643611:C:CG	donor_gain	0.8500
11:4644027:TGAG:T	donor_loss	0.8400
11:4644028:GAGGT:G	donor_loss	0.8400
11:4644029:AG:A	donor_loss	0.8400

AlphaMissense

2060 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000115115 (11:4653408 T>A,C,G), RS1000152160 (11:4642659 C>G,T), RS1000204942 (11:4642472 C>G,T), RS1000416777 (11:4647696 G>C,T), RS1000424032 (11:4646263 T>C), RS1000770658 (11:4651062 A>G), RS1000811896 (11:4652286 G>A), RS1000842928 (11:4652006 G>A,C), RS1001122142 (11:4652266 C>T), RS1001396631 (11:4653855 A>G), RS1001579935 (11:4647028 G>A), RS1001702163 (11:4653590 C>A), RS1001922915 (11:4647333 G>A,C), RS1002193848 (11:4647990 A>G,T), RS1002306376 (11:4642390 T>G)

Disease associations

OMIM: gene MIM:611267 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST006630_24	Diastolic blood pressure	1.000000e-10
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	decreases expression	1
butyraldehyde	decreases expression	1
pentanal	decreases expression	1
CGP 52608	affects binding, increases reaction	1
(+)-JQ1 compound	decreases expression	1
Aldehydes	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Nickel	decreases expression	1
Silicon Dioxide	decreases expression	1
Aflatoxin B1	increases methylation	1
Asbestos, Crocidolite	affects expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.