OR51F2

Summary

OR51F2 (olfactory receptor family 51 subfamily F member 2, HGNC:15197) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51F2 (Q8NH61). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 119694 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• MANE Select transcript: NM_001004753

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15197
Approved symbol	OR51F2
Name	olfactory receptor family 51 subfamily F member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176925
Ensembl biotype	protein_coding
Entrez	119694

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000322110, ENST00000641672

RefSeq mRNA: 1 — MANE Select: NM_001004753 NM_001004753

CCDS: CCDS31361

Canonical transcript exons

ENST00000322110 — 1 exons

Exon	Start	End
ENSE00003920805	4821321	4822456

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 51.40.

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	51.40	silver quality
lower esophagus mucosa	UBERON:0035834	39.06	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.88	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
monocyte	CL:0000576	29.21	gold quality
liver	UBERON:0002107	29.14	gold quality
leukocyte	CL:0000738	29.06	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.11	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
muscle of leg	UBERON:0001383	25.59	gold quality
right lobe of liver	UBERON:0001114	25.20	gold quality
calcaneal tendon	UBERON:0003701	24.94	gold quality
kidney	UBERON:0002113	24.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.47

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51f2	ENSMUSG00000073965
rattus_norvegicus	Or51f2	ENSRNOG00000015424

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51F2 — Q8NH61 (reviewed: Q8NH61)

Alternative names: Olfactory receptor OR11-23

All UniProt accessions (2): A0A2C9F2M5, Q8NH61

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004753* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH61-F1	86.19	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 111–203

Glycosylation sites (1): 17

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 23 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, IGLV5_37_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

162 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51F2	OLFM2	O95897	348
OR51F2	TRIM68	Q6AZZ1	305
OR51F2	IP6K3	Q96PC2	301
OR51F2	TLDC2	A0PJX2	270
OR51F2	FREM3	P0C091	269
OR51F2	ZRANB2	O95218	267
OR51F2	HBG1	P02096	264
OR51F2	SPATA18	Q8TC71	259
OR51F2	KIF23	Q02241	248
OR51F2	ASPM	Q8IZT6	247
OR51F2	COXFA4L2	Q9NRX3	245
OR51F2	OR4A16	Q8NH70	239
OR51F2	TRIM34	Q9BYJ4	226
OR51F2	PRDM5	Q9NQX1	220
OR51F2	A0A0J9YYA3	A0A0J9YYA3	212

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR51F2	PDIA6	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): OR51F2 (Proximity Label-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

341 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4821499:G:GG	donor_gain	0.9300
11:4821498:A:AG	donor_gain	0.7900
11:4821598:GCC:G	donor_gain	0.6700
11:4821594:A:AG	donor_gain	0.6600
11:4822048:A:AG	acceptor_gain	0.6600
11:4822049:G:GG	acceptor_gain	0.6600
11:4822086:T:TA	acceptor_gain	0.6500
11:4821483:GCC:G	donor_gain	0.6300
11:4821600:C:CG	donor_gain	0.6300
11:4822107:GCATT:G	acceptor_gain	0.6300
11:4821600:C:G	donor_gain	0.6200
11:4822043:A:AG	acceptor_gain	0.6200
11:4821607:C:CG	donor_gain	0.6100
11:4822048:AG:A	acceptor_gain	0.6100
11:4822049:GG:G	acceptor_gain	0.6100
11:4821411:A:AG	acceptor_gain	0.6000
11:4821412:G:GG	acceptor_gain	0.6000
11:4821820:A:G	donor_gain	0.6000
11:4822046:ACAG:A	acceptor_gain	0.6000
11:4821946:C:A	donor_gain	0.5900
11:4822049:GGGT:G	acceptor_gain	0.5900
11:4821594:A:G	donor_gain	0.5800
11:4821861:GGA:G	donor_gain	0.5800
11:4821919:G:GT	donor_gain	0.5800
11:4822048:AGG:A	acceptor_gain	0.5800
11:4822049:GGG:G	acceptor_gain	0.5800
11:4821863:A:G	donor_gain	0.5700
11:4821871:GTTGA:G	donor_gain	0.5700
11:4821872:TTGAT:T	donor_gain	0.5700
11:4822107:GC:G	acceptor_gain	0.5700

AlphaMissense

2173 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4821929:T:C	F182L	0.923
11:4821931:C:A	F182L	0.923
11:4821931:C:G	F182L	0.923
11:4822196:A:C	S271R	0.886
11:4822198:T:A	S271R	0.886
11:4822198:T:G	S271R	0.886
11:4822178:T:C	F265L	0.871
11:4822180:C:A	F265L	0.871
11:4822180:C:G	F265L	0.871
11:4821461:T:C	F26L	0.852
11:4821463:C:A	F26L	0.852
11:4821463:C:G	F26L	0.852
11:4822265:T:C	F294L	0.838
11:4822267:T:A	F294L	0.838
11:4822267:T:G	F294L	0.838
11:4821964:C:G	C193W	0.837
11:4821731:T:C	F116L	0.830
11:4821733:C:A	F116L	0.830
11:4821733:C:G	F116L	0.830
11:4821978:T:C	L198P	0.827
11:4821794:T:C	F137L	0.826
11:4821796:T:A	F137L	0.826
11:4821796:T:G	F137L	0.826
11:4821962:T:A	C193S	0.818
11:4821963:G:C	C193S	0.818
11:4821641:A:C	S86R	0.799
11:4821643:C:A	S86R	0.799
11:4821643:C:G	S86R	0.799
11:4821792:G:C	R136P	0.799
11:4821962:T:C	C193R	0.797

dbSNP variants (sampled 300 via entrez): RS1000381622 (11:4820289 A>G), RS1000579753 (11:4820654 C>A), RS1001900909 (11:4819953 C>T), RS1002506790 (11:4820190 T>C), RS1003517169 (11:4819878 C>A), RS1005189792 (11:4822434 T>C), RS1006204353 (11:4821188 A>C), RS1006350678 (11:4819768 T>TG), RS1007132321 (11:4821748 T>C), RS1008170329 (11:4820949 T>G), RS1009136102 (11:4819402 G>A,C), RS1009225568 (11:4820221 C>T), RS1012553181 (11:4820223 T>C), RS1013048742 (11:4822481 C>A,T), RS1013278165 (11:4822668 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

4 total (human), top 4 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Plant Extracts	decreases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.