OR51G1

Summary

OR51G1 (olfactory receptor family 51 subfamily G member 1, HGNC:14738) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51G1 (Q8NGK1). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional.

Source: NCBI Gene 79324 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• MANE Select transcript: NM_001005237

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14738
Approved symbol	OR51G1
Name	olfactory receptor family 51 subfamily G member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000278870
Ensembl biotype	protein_coding
Entrez	79324

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000623849

RefSeq mRNA: 1 — MANE Select: NM_001005237 NM_001005237

Canonical transcript exons

ENST00000623849 — 1 exons

Exon	Start	End
ENSE00003755280	4923374	4924339

Expression profiles

Bgee: expression breadth not_expressed, 0 present calls, max score 40.90.

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	40.90	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
sural nerve	UBERON:0015488	36.17	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.21	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
adrenal tissue	UBERON:0018303	27.41	gold quality
tonsil	UBERON:0002372	27.05	gold quality
leukocyte	CL:0000738	26.80	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
blood	UBERON:0000178	25.96	gold quality
monocyte	CL:0000576	25.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	24.87	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51g1	ENSMUSG00000045792
rattus_norvegicus	Or51g1	ENSRNOG00000015673

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409)

Protein

Protein identifiers

Olfactory receptor 51G1 — Q8NGK1 (reviewed: Q8NGK1)

Alternative names: Olfactory receptor 51G3, Olfactory receptor OR11-29

All UniProt accessions (2): Q8NGK1, A0A126GVF5

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005237* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGK1-F1	87.42	0.62

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–191

Glycosylation sites (1): 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MARTENS_TRETINOIN_RESPONSE_UP, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51G1	CFAP52	Q8N1V2	447
OR51G1	OR2C1	O95371	443
OR51G1	OR1J2	Q8NGS2	434
OR51G1	AMER2	Q8N7J2	433
OR51G1	XKR4	Q5GH76	374
OR51G1	TAFA5	Q7Z5A7	372
OR51G1	OR2L13	Q8N349	370
OR51G1	TPST1	O60507	349
OR51G1	NIPAL4	Q0D2K0	348
OR51G1	OR4M1	Q8NGD0	344
OR51G1	FAM221A	A4D161	336
OR51G1	TEX22	C9J3V5	323
OR51G1	RIOK3	O14730	322
OR51G1	FOXD2	O60548	316
OR51G1	TMEM143	Q96AN5	315

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

275 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4923680:G:C	acceptor_gain	0.7100
11:4923662:G:T	acceptor_gain	0.7000
11:4923546:CGA:C	acceptor_gain	0.6900
11:4923636:T:A	donor_gain	0.6900
11:4923661:CGG:C	acceptor_gain	0.6900
11:4923679:C:CT	acceptor_gain	0.6800
11:4923541:C:CT	acceptor_gain	0.6700
11:4923418:T:TA	donor_gain	0.6600
11:4923666:C:CT	acceptor_gain	0.6600
11:4923680:G:GC	acceptor_gain	0.6600
11:4923725:C:CT	acceptor_gain	0.6600
11:4923578:G:C	acceptor_gain	0.6500
11:4923725:C:T	acceptor_gain	0.6200
11:4923548:A:C	acceptor_gain	0.6100
11:4923659:CACGG:C	acceptor_gain	0.6100
11:4923592:CA:C	donor_gain	0.6000
11:4923592:CAGCA:C	donor_gain	0.6000
11:4923569:CA:C	acceptor_gain	0.5900
11:4923591:A:AC	donor_gain	0.5900
11:4923592:C:CC	donor_gain	0.5900
11:4923672:A:C	acceptor_gain	0.5900
11:4923489:A:T	acceptor_gain	0.5700
11:4923570:A:C	acceptor_gain	0.5700
11:4923593:A:AC	donor_gain	0.5700
11:4923578:G:GC	acceptor_gain	0.5600
11:4923592:CAG:C	donor_gain	0.5500
11:4923542:A:T	acceptor_gain	0.5400
11:4923547:G:T	acceptor_gain	0.5400
11:4923595:C:CT	acceptor_gain	0.5400
11:4923916:A:C	donor_gain	0.5400

AlphaMissense

2092 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4924028:G:C	F104L	0.883
11:4924028:G:T	F104L	0.883
11:4924030:A:G	F104L	0.883
11:4923542:A:C	F266L	0.867
11:4923542:A:T	F266L	0.867
11:4923544:A:G	F266L	0.867
11:4924298:G:C	F14L	0.819
11:4924298:G:T	F14L	0.819
11:4924300:A:G	F14L	0.819
11:4923581:G:C	F253L	0.817
11:4923581:G:T	F253L	0.817
11:4923583:A:G	F253L	0.817
11:4923749:A:C	N197K	0.811
11:4923749:A:T	N197K	0.811
11:4924240:A:G	C34R	0.786
11:4924283:G:C	F19L	0.779
11:4924283:G:T	F19L	0.779
11:4924285:A:G	F19L	0.779
11:4924114:A:G	C76R	0.765
11:4923797:A:C	C181W	0.744
11:4924034:C:A	Q102H	0.738
11:4924034:C:G	Q102H	0.738
11:4924043:A:C	C99W	0.729
11:4924078:A:G	W88R	0.723
11:4924078:A:T	W88R	0.723
11:4923798:C:G	C181S	0.719
11:4923799:A:T	C181S	0.719
11:4924241:G:C	F33L	0.699
11:4924241:G:T	F33L	0.699
11:4924243:A:G	F33L	0.699

dbSNP variants (sampled 300 via entrez): RS1000034796 (11:4923187 C>T), RS1002931791 (11:4926234 G>A), RS1004542494 (11:4925067 G>A), RS1004721370 (11:4925090 G>A,C), RS1004832275 (11:4924851 G>A), RS1006627101 (11:4926206 A>G), RS1007751846 (11:4923248 C>A,T), RS1008473271 (11:4925916 A>G), RS1009060936 (11:4924736 C>T), RS1009074612 (11:4926265 A>G,T), RS1009503750 (11:4924398 C>A,G,T), RS1010139848 (11:4924203 G>A,C), RS1011100327 (11:4925721 G>A,T), RS1012607761 (11:4925337 A>C), RS1016065194 (11:4925097 A>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, affects methylation, decreases methylation	2
CGP 52608	increases reaction, affects binding	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
Resveratrol	decreases expression, affects cotreatment	1
Catechin	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.