OR51G2

Summary

OR51G2 (olfactory receptor family 51 subfamily G member 2, HGNC:15198) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51G2 (Q8NGK0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 81282 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 1 total — 1 likely-pathogenic
• MANE Select transcript: NM_001005238

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15198
Approved symbol	OR51G2
Name	olfactory receptor family 51 subfamily G member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176893
Ensembl biotype	protein_coding
Entrez	81282

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000641926

RefSeq mRNA: 1 — MANE Select: NM_001005238 NM_001005238

CCDS: CCDS31365

Canonical transcript exons

ENST00000641926 — 2 exons

Exon	Start	End
ENSE00003811798	4912588	4915739
ENSE00003813847	4919177	4919350

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 87.43.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.43	silver quality
bone marrow cell	CL:0002092	38.12	gold quality
granulocyte	CL:0000094	37.40	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
apex of heart	UBERON:0002098	34.84	gold quality
leukocyte	CL:0000738	33.58	gold quality
monocyte	CL:0000576	33.53	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.20	gold quality
tonsil	UBERON:0002372	28.71	gold quality
liver	UBERON:0002107	28.59	gold quality
duodenum	UBERON:0002114	28.14	gold quality
lymph node	UBERON:0000029	27.57	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
blood	UBERON:0000178	26.46	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	25.40	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.94

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51g2	ENSMUSG00000043354
rattus_norvegicus	Or51g2	ENSRNOG00000015657

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51G2 — Q8NGK0 (reviewed: Q8NGK0)

Alternative names: Olfactory receptor OR11-28

All UniProt accessions (1): Q8NGK0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005238* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (20 total): topological domain 8, transmembrane region 7, sequence variant 2, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGK0-F1	87.65	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 102–194

Glycosylation sites (1): 8

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

130 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51G2	OTOP3	Q7RTS5	441
OR51G2	OR1J2	Q8NGS2	420
OR51G2	RIMBP3	Q9UFD9	418
OR51G2	OR2C1	O95371	411
OR51G2	PSTK	Q8IV42	366
OR51G2	VPS13D	Q5THJ4	348
OR51G2	ARAP3	Q8WWN8	308
OR51G2	TMEM143	Q96AN5	305
OR51G2	ZFYVE26	Q68DK2	303
OR51G2	NUP210	Q8TEM1	266
OR51G2	BPIFC	Q8NFQ6	259
OR51G2	RSPH14	Q9UHP6	252
OR51G2	ZFP57	Q9NU63	247
OR51G2	ANP32A	P39687	244
OR51G2	EDIL3	O43854	226

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK0, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
226252	GRCh37/hg19 11p15.4(chr11:4371631-5253127)	Likely pathogenic

SpliceAI

314 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4915609:G:C	donor_gain	0.9200
11:4915548:A:C	donor_gain	0.8800
11:4915541:CAGA:C	donor_gain	0.8300
11:4915103:T:C	acceptor_gain	0.8200
11:4915526:G:A	donor_gain	0.8000
11:4914989:C:CT	acceptor_gain	0.7800
11:4914994:C:CT	acceptor_gain	0.7600
11:4914793:C:CT	acceptor_gain	0.7400
11:4914791:C:CT	acceptor_gain	0.7300
11:4914990:A:T	acceptor_gain	0.7300
11:4915475:A:AC	donor_gain	0.7200
11:4915476:G:C	donor_gain	0.7100
11:4914995:A:C	acceptor_gain	0.7000
11:4915099:CTT:C	acceptor_gain	0.7000
11:4914794:A:T	acceptor_gain	0.6900
11:4915540:CCAG:C	donor_gain	0.6500
11:4915608:AG:A	donor_gain	0.6300
11:4915097:CACTT:C	acceptor_gain	0.6000
11:4915103:T:TC	acceptor_gain	0.5800
11:4915608:A:AC	donor_gain	0.5800
11:4914771:C:CC	acceptor_gain	0.5700
11:4914788:C:CT	acceptor_gain	0.5700
11:4915475:AGGTT:A	donor_gain	0.5700
11:4915198:G:GT	donor_gain	0.5500
11:4914769:CA:C	acceptor_gain	0.5300
11:4914912:C:CT	acceptor_gain	0.5300
11:4915194:C:CT	donor_gain	0.5300
11:4915195:T:TT	donor_gain	0.5300
11:4914984:A:T	acceptor_gain	0.5200
11:4915523:G:C	donor_gain	0.5100

AlphaMissense

2055 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4915193:A:C	S157R	0.933
11:4915193:A:T	S157R	0.933
11:4915195:T:G	S157R	0.933
11:4914896:G:C	F256L	0.931
11:4914896:G:T	F256L	0.931
11:4914898:A:G	F256L	0.931
11:4915295:C:A	M123I	0.922
11:4915295:C:G	M123I	0.922
11:4915295:C:T	M123I	0.922
11:4915343:A:C	F107L	0.922
11:4915343:A:T	F107L	0.922
11:4915345:A:G	F107L	0.922
11:4915613:G:C	F17L	0.903
11:4915613:G:T	F17L	0.903
11:4915615:A:G	F17L	0.903
11:4915112:A:C	C184W	0.898
11:4914770:A:C	S298R	0.896
11:4914770:A:T	S298R	0.896
11:4914772:T:G	S298R	0.896
11:4915358:G:C	C102W	0.895
11:4915113:C:G	C184S	0.894
11:4915114:A:T	C184S	0.894
11:4915284:C:G	R127P	0.894
11:4914857:A:C	F269L	0.881
11:4914857:A:T	F269L	0.881
11:4914859:A:G	F269L	0.881
11:4915161:A:T	L168H	0.881
11:4914785:A:C	N293K	0.873
11:4914785:A:T	N293K	0.873
11:4915114:A:G	C184R	0.871

dbSNP variants (sampled 300 via entrez): RS1000050956 (11:4918911 A>G), RS1000248173 (11:4917421 C>T), RS1000486087 (11:4918510 G>T), RS1001460038 (11:4917384 A>G), RS1001600174 (11:4914382 C>G,T), RS1001659803 (11:4916440 C>T), RS1001758312 (11:4919921 C>G), RS1002528710 (11:4915513 G>T), RS1003165697 (11:4915761 A>AG), RS1003533869 (11:4914378 T>C), RS1003591391 (11:4920109 G>T), RS1003871287 (11:4915400 G>A,T), RS1003894336 (11:4920975 A>G), RS1004001146 (11:4921171 T>A), RS1004993183 (11:4913908 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.