OR51M1

Summary

OR51M1 (olfactory receptor family 51 subfamily M member 1, HGNC:14847) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51M1 (Q9H341). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390059 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• MANE Select transcript: NM_001004756

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14847
Approved symbol	OR51M1
Name	olfactory receptor family 51 subfamily M member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000184698
Ensembl biotype	protein_coding
Entrez	390059

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000328611, ENST00000641529, ENST00000642046

RefSeq mRNA: 1 — MANE Select: NM_001004756 NM_001004756

CCDS: CCDS53596

Canonical transcript exons

ENST00000642046 — 3 exons

Exon	Start	End
ENSE00003812431	5385353	5385458
ENSE00003813779	5389384	5393263
ENSE00003814218	5383812	5383917

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 76.03.

Top tissues by expression

102 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.03	silver quality
bone marrow cell	CL:0002092	50.91	silver quality
colonic epithelium	UBERON:0000397	46.10	gold quality
bone marrow	UBERON:0002371	41.68	silver quality
tonsil	UBERON:0002372	40.40	gold quality
stromal cell of endometrium	CL:0002255	39.99	gold quality
granulocyte	CL:0000094	39.21	gold quality
apex of heart	UBERON:0002098	38.61	silver quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
corpus callosum	UBERON:0002336	35.63	gold quality
adrenal tissue	UBERON:0018303	35.52	gold quality
monocyte	CL:0000576	35.26	gold quality
leukocyte	CL:0000738	35.22	gold quality
skeletal muscle tissue	UBERON:0001134	35.00	gold quality
mucosa of transverse colon	UBERON:0004991	34.81	gold quality
liver	UBERON:0002107	34.58	gold quality
uterine cervix	UBERON:0000002	34.49	gold quality
muscle tissue	UBERON:0002385	33.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	32.32	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
left uterine tube	UBERON:0001303	32.07	gold quality
cerebellum	UBERON:0002037	32.04	gold quality
cerebellar cortex	UBERON:0002129	31.95	gold quality
myometrium	UBERON:0001296	31.94	gold quality
ovary	UBERON:0000992	31.74	gold quality
cerebellar hemisphere	UBERON:0002245	31.73	gold quality
cortex of kidney	UBERON:0001225	31.62	gold quality
left ovary	UBERON:0002119	31.41	gold quality
lymph node	UBERON:0000029	31.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.10

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51m1	ENSMUSG00000042219

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51M1 — Q9H341 (reviewed: Q9H341)

Alternative names: Odorant receptor HOR5’beta7, Olfactory receptor OR11-40

All UniProt accessions (1): Q9H341

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004756* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (24 total): topological domain 8, transmembrane region 7, sequence variant 6, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H341-F1	86.41	0.58

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 109–201

Glycosylation sites (1): 16

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 24 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, CHEN_METABOLIC_SYNDROM_NETWORK, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, HBZ_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY

GO Biological Process (6): sensory perception of smell (GO:0007608), cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
sensory perception of chemical stimulus	1
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

196 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51M1	FAM221A	A4D161	571
OR51M1	ZNF417	Q8TAU3	447
OR51M1	UNC93A	Q86WB7	435
OR51M1	HBE1	P02100	379
OR51M1	NPBWR2	P48146	371
OR51M1	ADGRG7	Q96K78	354
OR51M1	GRIP2	Q9C0E4	329
OR51M1	GLRA2	P23416	324
OR51M1	A0A0J9YYA3	A0A0J9YYA3	298
OR51M1	SLC5A11	Q8WWX8	290
OR51M1	FOLR2	P14207	289
OR51M1	FOLR1	P15328	269
OR51M1	HBD	P02042	249
OR51M1	HRNR	Q86YZ3	238
OR51M1	RPS13	P19116	227

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR51M1	HDLBP	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (2): OR51M1 (Proximity Label-MS), OR51M1 (Negative Genetic)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

367 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5389868:GCC:G	donor_gain	0.7100
11:5390042:T:TG	donor_gain	0.6300
11:5389976:ACCAG:A	acceptor_gain	0.6200
11:5389977:C:G	acceptor_gain	0.6200
11:5389980:GGAA:G	acceptor_gain	0.6100
11:5389965:ATTTT:A	acceptor_gain	0.6000
11:5390006:A:G	donor_gain	0.6000
11:5390043:A:AA	donor_gain	0.5900
11:5390182:G:GG	donor_gain	0.5900
11:5389496:A:T	donor_gain	0.5800
11:5390178:GCTA:G	donor_gain	0.5800
11:5387467:CCCT:C	donor_gain	0.5700
11:5389941:T:TA	acceptor_gain	0.5700
11:5390045:T:G	donor_gain	0.5700
11:5389965:A:AG	acceptor_gain	0.5500
11:5389981:G:GT	donor_gain	0.5500
11:5389969:T:TA	acceptor_gain	0.5400
11:5390039:T:TA	donor_gain	0.5400
11:5387465:ACC:A	donor_gain	0.5300
11:5387466:CCC:C	donor_gain	0.5300
11:5389456:T:G	donor_gain	0.5300
11:5390027:AT:A	acceptor_gain	0.5300
11:5390179:C:G	donor_gain	0.5300
11:5390229:G:GT	donor_gain	0.5300
11:5389860:C:A	donor_gain	0.5200
11:5389979:A:AG	acceptor_gain	0.5200
11:5389980:G:GG	acceptor_gain	0.5200
11:5390040:GGT:G	donor_gain	0.5200
11:5390174:C:CG	donor_gain	0.5100
11:5390176:GT:G	donor_gain	0.5100

AlphaMissense

2140 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5389966:T:C	F190L	0.901
11:5389968:T:A	F190L	0.901
11:5389968:T:G	F190L	0.901
11:5390224:T:C	F276L	0.844
11:5390226:T:A	F276L	0.844
11:5390226:T:G	F276L	0.844
11:5390185:T:C	F263L	0.817
11:5390187:C:A	F263L	0.817
11:5390187:C:G	F263L	0.817
11:5389738:T:C	F114L	0.802
11:5389740:C:A	F114L	0.802
11:5389740:C:G	F114L	0.802
11:5390188:T:C	F264L	0.754
11:5390190:T:A	F264L	0.754
11:5390190:T:G	F264L	0.754
11:5390311:A:C	S305R	0.700
11:5390313:C:A	S305R	0.700
11:5390313:C:G	S305R	0.700
11:5389930:T:C	F178L	0.698
11:5389932:T:A	F178L	0.698
11:5389932:T:G	F178L	0.698
11:5390319:G:C	K307N	0.698
11:5390319:G:T	K307N	0.698
11:5389753:T:C	F119L	0.686
11:5389755:T:A	F119L	0.686
11:5389755:T:G	F119L	0.686
11:5389741:T:C	C115R	0.674
11:5390064:C:A	D222E	0.673
11:5390064:C:G	D222E	0.673
11:5389792:T:C	F132L	0.651

dbSNP variants (sampled 300 via entrez): RS1000047262 (11:5382549 A>G), RS1000308839 (11:5391390 C>G), RS1000646475 (11:5383612 T>C), RS1000705979 (11:5388110 T>C), RS1000758485 (11:5387794 C>G), RS1001309702 (11:5392629 C>A,G), RS1001516982 (11:5385823 A>C,T), RS1001550860 (11:5383319 G>A,T), RS1001744890 (11:5387727 C>T), RS1002038039 (11:5384183 G>A), RS1002185076 (11:5388621 T>C), RS1002226674 (11:5391444 G>C), RS1002238924 (11:5388481 A>G), RS1002398217 (11:5392798 G>T), RS1002493826 (11:5384018 G>A,C,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases methylation	1
Asbestos, Crocidolite	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.