OR51T1

Summary

OR51T1 (olfactory receptor family 51 subfamily T member 1, HGNC:15205) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 51T1 (Q8NGJ9). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 401665 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 1 total
• MANE Select transcript: NM_001004759

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15205
Approved symbol	OR51T1
Name	olfactory receptor family 51 subfamily T member 1
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000176900
Ensembl biotype	protein_coding
Entrez	401665

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000322049, ENST00000380378

RefSeq mRNA: 1 — MANE Select: NM_001004759 NM_001004759

CCDS: CCDS31363

Canonical transcript exons

ENST00000322049 — 1 exons

Exon	Start	End
ENSE00001282591	4881900	4882883

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 42.20.

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	42.20	gold quality
sural nerve	UBERON:0015488	39.18	gold quality
granulocyte	CL:0000094	37.60	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
leukocyte	CL:0000738	30.99	gold quality
monocyte	CL:0000576	30.67	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.04	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
right coronary artery	UBERON:0001625	27.74	gold quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.07	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	25.14	gold quality
primary visual cortex	UBERON:0002436	24.61	gold quality
fundus of stomach	UBERON:0001160	24.45	gold quality
superior frontal gyrus	UBERON:0002661	24.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or51t4	ENSMUSG00000045824
rattus_norvegicus	Or51t1	ENSRNOG00000048436

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 51T1 — Q8NGJ9 (reviewed: Q8NGJ9)

Alternative names: Olfactory receptor OR11-26

All UniProt accessions (2): A0A0C4DFX5, Q8NGJ9

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004759* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (18 total): topological domain 8, transmembrane region 7, glycosylation site 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGJ9-F1	86.37	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (2): 5, 6

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 20 (showing top): GOBP_CELLULAR_RESPONSE_TO_LIPID, GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_RESPONSE_TO_LIPID, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, SUPT16H_TARGET_GENES, REACTOME_OLFACTORY_SIGNALING_PATHWAY, FOURATI_BLOOD_TWINRIX_AGE_25_83YO_RESPONDERS_VS_POOR_RESPONDERS_0DY_DN

GO Biological Process (6): cellular response to lipid (GO:0071396), system process (GO:0003008), signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984), signaling receptor activity (GO:0038023)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
response to lipid	1
cellular response to chemical stimulus	1
multicellular organismal process	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
molecular transducer activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

192 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR51T1	KCNV1	Q6PIU1	538
OR51T1	KRTAP1-4	P0C5Y4	507
OR51T1	ADGRF3	Q8IZF5	463
OR51T1	F13B	P05160	445
OR51T1	RASL10B	Q96S79	436
OR51T1	CWH43	Q9H720	428
OR51T1	DIRAS1	O95057	418
OR51T1	PCDHGA1	Q9Y5H4	392
OR51T1	SNX19	Q92543	386
OR51T1	ARHGEF26	Q96DR7	385
OR51T1	TAAR5	O14804	379
OR51T1	EVI5	O60447	373
OR51T1	CANT1	Q8WVQ1	361
OR51T1	RHOBTB3	O94955	361
OR51T1	EPGN	Q6UW88	357

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

244 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4882033:G:GG	donor_gain	0.9500
11:4882032:A:AG	donor_gain	0.9100
11:4882559:T:G	acceptor_gain	0.9000
11:4882081:T:G	donor_gain	0.8600
11:4881879:GTTCA:G	acceptor_gain	0.8000
11:4882558:A:AG	acceptor_gain	0.8000
11:4882564:T:A	acceptor_gain	0.8000
11:4882037:G:GT	donor_gain	0.7700
11:4882085:T:TG	donor_gain	0.7700
11:4881878:A:AG	acceptor_gain	0.7400
11:4881879:G:GG	acceptor_gain	0.7400
11:4882559:T:TA	acceptor_gain	0.7200
11:4882411:ATGGG:A	acceptor_gain	0.7000
11:4881904:C:T	donor_gain	0.6900
11:4882536:G:GG	donor_gain	0.6800
11:4881877:TAG:T	acceptor_gain	0.6700
11:4882558:AT:A	acceptor_gain	0.6700
11:4881967:A:T	donor_gain	0.6600
11:4882535:C:CG	donor_gain	0.6300
11:4882572:C:A	acceptor_gain	0.6100
11:4881875:CATAG:C	acceptor_gain	0.6000
11:4881878:AGTT:A	acceptor_gain	0.6000
11:4881906:A:AG	donor_gain	0.6000
11:4882411:ATGG:A	acceptor_gain	0.5900
11:4882028:A:T	donor_gain	0.5800
11:4882592:G:A	acceptor_gain	0.5800
11:4882335:A:AG	donor_gain	0.5700
11:4882575:ACT:A	acceptor_gain	0.5700
11:4882601:G:GT	donor_gain	0.5700
11:4881879:G:T	acceptor_gain	0.5600

AlphaMissense

2136 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:4882437:T:C	F180L	0.954
11:4882439:T:A	F180L	0.954
11:4882439:T:G	F180L	0.954
11:4882674:A:C	S259R	0.906
11:4882676:C:A	S259R	0.906
11:4882676:C:G	S259R	0.906
11:4882656:T:C	F253L	0.877
11:4882658:C:A	F253L	0.877
11:4882658:C:G	F253L	0.877
11:4881939:T:C	F14L	0.847
11:4881941:C:A	F14L	0.847
11:4881941:C:G	F14L	0.847
11:4882270:G:C	R124P	0.829
11:4881954:T:C	F19L	0.827
11:4881956:C:A	F19L	0.827
11:4881956:C:G	F19L	0.827
11:4882032:A:C	S45R	0.821
11:4882034:T:A	S45R	0.821
11:4882034:T:G	S45R	0.821
11:4882407:T:C	F170L	0.821
11:4882409:T:A	F170L	0.821
11:4882409:T:G	F170L	0.821
11:4882440:T:A	C181S	0.820
11:4882441:G:C	C181S	0.820
11:4882259:G:A	M120I	0.813
11:4882259:G:C	M120I	0.813
11:4882259:G:T	M120I	0.813
11:4882567:T:C	I223T	0.807
11:4882442:C:G	C181W	0.804
11:4882268:C:A	D123E	0.803

dbSNP variants (sampled 300 via entrez): RS1001344812 (11:4883272 G>A), RS1001710758 (11:4880903 C>T), RS1001810500 (11:4880685 T>C), RS1002418342 (11:4881846 A>G,T), RS1003308728 (11:4880825 A>G), RS1003424880 (11:4880507 A>G), RS1003856139 (11:4881721 T>C), RS1004461992 (11:4881749 T>C), RS1004978160 (11:4880183 C>G,T), RS1005460973 (11:4880653 A>G), RS1005719230 (11:4883004 A>G,T), RS1006123880 (11:4883340 G>A), RS1008313896 (11:4881291 C>T), RS1008906295 (11:4880093 C>G,T), RS1009309389 (11:4880400 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	affects methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.