OR52B2

Summary

OR52B2 (olfactory receptor family 52 subfamily B member 2, HGNC:15207) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52B2 (Q96RD2). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 255725 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 62 total
• MANE Select transcript: NM_001004052

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15207
Approved symbol	OR52B2
Name	olfactory receptor family 52 subfamily B member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000255307
Ensembl biotype	protein_coding
Entrez	255725

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000530810

RefSeq mRNA: 1 — MANE Select: NM_001004052 NM_001004052

CCDS: CCDS53598

Canonical transcript exons

ENST00000530810 — 1 exons

Exon	Start	End
ENSE00004001352	6169355	6170326

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 52.88.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	52.88	gold quality
bone marrow cell	CL:0002092	40.97	gold quality
ganglionic eminence	UBERON:0004023	37.69	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
skeletal muscle tissue	UBERON:0001134	34.92	gold quality
bone marrow	UBERON:0002371	34.20	gold quality
monocyte	CL:0000576	34.01	gold quality
leukocyte	CL:0000738	33.43	gold quality
muscle tissue	UBERON:0002385	33.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
blood	UBERON:0000178	31.69	gold quality
primary visual cortex	UBERON:0002436	31.55	gold quality
liver	UBERON:0002107	31.30	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
prefrontal cortex	UBERON:0000451	30.77	gold quality
right uterine tube	UBERON:0001302	30.45	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
tonsil	UBERON:0002372	28.67	gold quality
duodenum	UBERON:0002114	28.14	gold quality
smooth muscle tissue	UBERON:0001135	27.97	gold quality
corpus callosum	UBERON:0002336	27.88	gold quality
placenta	UBERON:0001987	27.71	gold quality
lymph node	UBERON:0000029	27.57	gold quality
right coronary artery	UBERON:0001625	27.54	gold quality
urinary bladder	UBERON:0001255	26.99	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52b2	ENSMUSG00000043948
rattus_norvegicus	Or52b2	ENSRNOG00000025819

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409)

Protein

Protein identifiers

Olfactory receptor 52B2 — Q96RD2 (reviewed: Q96RD2)

Alternative names: Olfactory receptor OR11-70

All UniProt accessions (1): Q96RD2

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001004052* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96RD2-F1	86.79	0.54

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–191

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 16 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11p15

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

242 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52B2	CNGA4	Q8IV77	542
OR52B2	MSANTD1	Q6ZTZ1	519
OR52B2	SAP130	Q9H0E3	482
OR52B2	CATSPER3	Q86XQ3	435
OR52B2	OR1J2	Q8NGS2	405
OR52B2	OR2C1	O95371	396
OR52B2	SNUPN	O95149	382
OR52B2	YPEL4	Q96NS1	370
OR52B2	NUDT16L1	Q9BRJ7	348
OR52B2	GPR171	O14626	324
OR52B2	THSD7B	Q9C0I4	320
OR52B2	GIMAP2	Q9UG22	313
OR52B2	STARD9	Q9P2P6	307
OR52B2	GPR87	Q9BY21	305
OR52B2	NLRP11	P59045	305

IntAct

2 interactions, top by confidence:

A	B	Type	Score
OR52B2	PCCA	psi-mi:“MI:0914”(association)	0.350

BioGRID (18): OR5C1 (Affinity Capture-MS), PTX3 (Affinity Capture-MS), KCMF1 (Affinity Capture-MS), ZNF699 (Affinity Capture-MS), C1orf198 (Affinity Capture-MS), ZNF709 (Affinity Capture-MS), SLC9A3R2 (Affinity Capture-MS), ZNF444 (Affinity Capture-MS), PCCA (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), PCCB (Affinity Capture-MS), NDE1 (Affinity Capture-MS), FAM81A (Affinity Capture-MS), ZNF852 (Affinity Capture-MS)

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

351 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6169481:A:C	acceptor_gain	0.7400
11:6169474:C:CC	acceptor_gain	0.7000
11:6169508:A:C	acceptor_gain	0.7000
11:6169579:TG:T	donor_gain	0.7000
11:6169662:A:T	acceptor_gain	0.6800
11:6169565:A:C	acceptor_gain	0.6700
11:6169846:C:CC	acceptor_gain	0.6600
11:6169579:TGAC:T	donor_gain	0.6500
11:6169520:A:AC	donor_gain	0.6300
11:6169444:CA:C	acceptor_gain	0.6100
11:6169559:TGGA:T	donor_gain	0.6000
11:6169575:A:C	donor_gain	0.5800
11:6170124:A:T	acceptor_gain	0.5800
11:6169478:CACA:C	acceptor_gain	0.5700
11:6169567:A:AC	donor_gain	0.5700
11:6169717:C:CC	acceptor_gain	0.5700
11:6169782:TCACA:T	acceptor_gain	0.5700
11:6169787:G:GC	acceptor_gain	0.5700
11:6169438:TCAC:T	donor_gain	0.5600
11:6169508:A:AC	acceptor_gain	0.5600
11:6169493:C:CT	acceptor_gain	0.5500
11:6169472:CA:C	acceptor_gain	0.5400
11:6169494:A:T	acceptor_gain	0.5400
11:6169541:CAA:C	acceptor_gain	0.5400
11:6169843:TGA:T	acceptor_gain	0.5400
11:6169568:A:C	donor_gain	0.5300
11:6169578:A:AC	donor_gain	0.5200
11:6169596:C:CT	donor_gain	0.5200
11:6169608:AGGG:A	donor_gain	0.5200
11:6169647:ACTGC:A	acceptor_gain	0.5200

AlphaMissense

2103 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6169817:G:C	F170L	0.871
11:6169817:G:T	F170L	0.871
11:6169819:A:G	F170L	0.871
11:6169425:A:G	I301T	0.849
11:6170015:G:C	F104L	0.848
11:6170015:G:T	F104L	0.848
11:6170017:A:G	F104L	0.848
11:6170192:G:C	S45R	0.835
11:6170192:G:T	S45R	0.835
11:6170194:T:G	S45R	0.835
11:6169568:A:C	F253L	0.819
11:6169568:A:T	F253L	0.819
11:6169570:A:G	F253L	0.819
11:6170285:A:C	F14L	0.791
11:6170285:A:T	F14L	0.791
11:6170287:A:G	F14L	0.791
11:6169952:A:C	F125L	0.790
11:6169952:A:T	F125L	0.790
11:6169954:A:G	F125L	0.790
11:6169997:A:C	F110L	0.782
11:6169997:A:T	F110L	0.782
11:6169999:A:G	F110L	0.782
11:6169865:G:C	S154R	0.779
11:6169865:G:T	S154R	0.779
11:6169867:T:G	S154R	0.779
11:6169425:A:T	I301K	0.774
11:6170039:A:C	F96L	0.757
11:6170039:A:T	F96L	0.757
11:6170041:A:G	F96L	0.757
11:6169613:C:A	K238N	0.732

dbSNP variants (sampled 300 via entrez): RS1000027535 (11:6171239 A>G), RS1000040505 (11:6170284 C>T), RS1001192342 (11:6170159 G>A,T), RS1002813982 (11:6171177 C>T), RS1005186092 (11:6172267 A>G), RS1006314395 (11:6169192 G>A), RS1009453685 (11:6169026 G>A,T), RS1011179205 (11:6170502 A>C), RS1012081438 (11:6168894 G>A), RS1014977159 (11:6172006 T>C), RS1015299518 (11:6170964 T>C), RS1016558699 (11:6172047 T>C), RS1016818279 (11:6168925 C>T), RS1016918815 (11:6171811 GGCCAAGAT>G), RS1017757300 (11:6169071 A>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression	1
CGP 52608	increases reaction, affects binding	1
Arsenic	affects methylation	1
Benzo(a)pyrene	decreases methylation	1
Cyclosporine	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.