OR52B6

Summary

OR52B6 (olfactory receptor family 52 subfamily B member 6, HGNC:15211) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52B6 (Q8NGF0). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 340980 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 38 total
• MANE Select transcript: NM_001005162

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15211
Approved symbol	OR52B6
Name	olfactory receptor family 52 subfamily B member 6
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000187747
Ensembl biotype	protein_coding
Entrez	340980

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000345043

RefSeq mRNA: 1 — MANE Select: NM_001005162 NM_001005162

CCDS: CCDS41611

Canonical transcript exons

ENST00000345043 — 1 exons

Exon	Start	End
ENSE00001263967	5580877	5581884

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 65.11.

Top tissues by expression

88 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	65.11	gold quality
calcaneal tendon	UBERON:0003701	57.48	gold quality
bone marrow cell	CL:0002092	43.61	gold quality
granulocyte	CL:0000094	43.03	silver quality
stromal cell of endometrium	CL:0002255	42.22	silver quality
colonic epithelium	UBERON:0000397	41.84	gold quality
tonsil	UBERON:0002372	39.36	gold quality
left ovary	UBERON:0002119	37.73	silver quality
apex of heart	UBERON:0002098	37.54	silver quality
skeletal muscle tissue	UBERON:0001134	37.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	36.84	gold quality
corpus callosum	UBERON:0002336	36.56	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
myometrium	UBERON:0001296	36.44	silver quality
right ovary	UBERON:0002118	35.73	silver quality
bone marrow	UBERON:0002371	35.55	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
muscle tissue	UBERON:0002385	34.02	gold quality
mucosa of stomach	UBERON:0001199	33.90	gold quality
leukocyte	CL:0000738	33.54	gold quality
monocyte	CL:0000576	33.28	gold quality
right uterine tube	UBERON:0001302	33.21	gold quality
adrenal tissue	UBERON:0018303	32.95	gold quality
endocervix	UBERON:0000458	31.10	gold quality
blood	UBERON:0000178	30.84	gold quality
cortex of kidney	UBERON:0001225	30.52	gold quality
superior frontal gyrus	UBERON:0002661	30.47	gold quality
prefrontal cortex	UBERON:0000451	29.76	gold quality
lymph node	UBERON:0000029	29.00	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52b6	ENSMUSG00000081859

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409), OR52J3 (ENSG00000205495)

Protein

Protein identifiers

Olfactory receptor 52B6 — Q8NGF0 (reviewed: Q8NGF0)

Alternative names: Olfactory receptor OR11-47

All UniProt accessions (1): Q8NGF0

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005162* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NGF0-F1	87.03	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 117–208

Glycosylation sites (1): 23

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-381753	Olfactory Signaling Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 18 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, REACTOME_OLFACTORY_SIGNALING_PATHWAY, HARALAMBIEVA_PBMC_M_M_R_II_AGE_11_22YO_VACCINATED_VS_UNVACCINATED_7YR_UP, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Sensory Perception	1
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

218 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52B6	ORMDL2	Q53FV1	479
OR52B6	VN1R4	Q7Z5H5	479
OR52B6	TRIM34	Q9BYJ4	476
OR52B6	TAS2R31	P59538	473
OR52B6	TRIM6	Q9C030	461
OR52B6	VN1R2	Q8NFZ6	447
OR52B6	VN1R1	Q9GZP7	446
OR52B6	TAS2R43	P59537	445
OR52B6	CNGA4	Q8IV77	441
OR52B6	C3orf62	Q6ZUJ4	434
OR52B6	TAAR2	Q9P1P5	379
OR52B6	USP17L19	D6RCP7	370
OR52B6	TAAR5	O14804	369
OR52B6	USP17L15	C9J2P7	368
OR52B6	TAAR1	Q96RJ0	359

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

251 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5581094:C:T	donor_gain	0.7300
11:5581642:GCCC:G	donor_gain	0.7200
11:5581059:C:T	donor_gain	0.7000
11:5581112:T:G	donor_gain	0.6500
11:5581117:A:G	donor_gain	0.5800
11:5581595:T:G	acceptor_gain	0.5800
11:5581645:C:CG	donor_gain	0.5800
11:5581550:CCACA:C	acceptor_loss	0.5700
11:5581551:CACA:C	acceptor_loss	0.5700
11:5581552:ACAG:A	acceptor_loss	0.5700
11:5581553:CAG:C	acceptor_loss	0.5700
11:5581554:A:C	acceptor_loss	0.5700
11:5581555:G:T	acceptor_loss	0.5700
11:5581054:G:GT	donor_gain	0.5600
11:5581423:G:GC	acceptor_gain	0.5600
11:5581641:GGCCC:G	donor_gain	0.5600
11:5581649:G:GG	donor_gain	0.5500
11:5581716:CTACA:C	acceptor_loss	0.5500
11:5581717:TACA:T	acceptor_loss	0.5500
11:5581719:CAGG:C	acceptor_loss	0.5500
11:5581720:A:T	acceptor_loss	0.5500
11:5581269:T:TA	acceptor_gain	0.5400
11:5581543:CTTCT:C	acceptor_loss	0.5400
11:5581548:CTCCA:C	acceptor_loss	0.5400
11:5581549:TCCAC:T	acceptor_loss	0.5400
11:5581541:CTCTT:C	acceptor_loss	0.5300
11:5581547:TCTCC:T	acceptor_loss	0.5300
11:5581587:C:G	acceptor_gain	0.5300
11:5581593:C:G	acceptor_gain	0.5300
11:5581542:TCTTC:T	acceptor_loss	0.5200

AlphaMissense

2211 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5581465:T:C	F197L	0.826
11:5581467:T:A	F197L	0.826
11:5581467:T:G	F197L	0.826
11:5581723:T:C	F283L	0.761
11:5581725:T:A	F283L	0.761
11:5581725:T:G	F283L	0.761
11:5581684:T:C	F270L	0.720
11:5581686:C:A	F270L	0.720
11:5581686:C:G	F270L	0.720
11:5581240:T:C	F122L	0.719
11:5581242:C:A	F122L	0.719
11:5581242:C:G	F122L	0.719
11:5581216:T:C	F114L	0.665
11:5581218:T:A	F114L	0.665
11:5581218:T:G	F114L	0.665
11:5581291:T:C	F139L	0.656
11:5581293:T:A	F139L	0.656
11:5581293:T:G	F139L	0.656
11:5581258:T:C	F128L	0.630
11:5581260:C:A	F128L	0.630
11:5581260:C:G	F128L	0.630
11:5581702:T:C	F276L	0.612
11:5581704:T:A	F276L	0.612
11:5581704:T:G	F276L	0.612
11:5581138:A:C	S88R	0.608
11:5581140:T:A	S88R	0.608
11:5581140:T:G	S88R	0.608
11:5581027:T:C	F51L	0.606
11:5581029:C:A	F51L	0.606
11:5581029:C:G	F51L	0.606

dbSNP variants (sampled 300 via entrez): RS1000660153 (11:5579406 G>A), RS1001258955 (11:5580308 GA>G,GAA), RS1002165771 (11:5579998 C>T), RS1002660519 (11:5579048 CAT>C), RS1002912380 (11:5581775 A>C), RS1004521829 (11:5578890 G>T), RS1005527315 (11:5580035 T>C), RS1007064990 (11:5580580 C>T), RS1008017646 (11:5581973 C>G,T), RS1009615888 (11:5579664 C>G), RS1010332114 (11:5580829 A>G), RS1010363512 (11:5581124 T>C), RS1011289068 (11:5580873 C>A), RS1011337884 (11:5582019 A>C,G), RS1011380647 (11:5582325 T>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST008863_4	Malate levels	8.000000e-07
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010508	malate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1
Benzo(a)pyrene	increases methylation	1
Lactic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.