OR52E5

Summary

OR52E5 (olfactory receptor family 52 subfamily E member 5, HGNC:15214) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52E5 (Q8NH55). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 390082 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001005166

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15214
Approved symbol	OR52E5
Name	olfactory receptor family 52 subfamily E member 5
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000277932
Ensembl biotype	protein_coding
Entrez	390082

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000610445

RefSeq mRNA: 1 — MANE Select: NM_001005166 NM_001005166

CCDS: CCDS91427

Canonical transcript exons

ENST00000610445 — 3 exons

Exon	Start	End
ENSE00003753940	5900632	5902730
ENSE00003812538	5895632	5895713
ENSE00003814278	5893208	5893270

Expression profiles

Bgee: expression breadth tissue_specific, 1 present calls, max score 80.65.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.65	gold quality
bone marrow cell	CL:0002092	38.11	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
sural nerve	UBERON:0015488	35.32	gold quality
granulocyte	CL:0000094	34.92	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	32.74	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
leukocyte	CL:0000738	31.88	gold quality
monocyte	CL:0000576	31.75	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.20	gold quality
tonsil	UBERON:0002372	28.72	gold quality
duodenum	UBERON:0002114	28.14	gold quality
liver	UBERON:0002107	28.04	gold quality
lymph node	UBERON:0000029	27.57	gold quality
primary visual cortex	UBERON:0002436	27.42	gold quality
urinary bladder	UBERON:0001255	26.73	gold quality
islet of Langerhans	UBERON:0000006	26.55	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.18	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	25.89	gold quality
placenta	UBERON:0001987	25.81	gold quality
adrenal tissue	UBERON:0018303	25.21	gold quality
calcaneal tendon	UBERON:0003701	24.87	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.80

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52e5	ENSMUSG00000073913
rattus_norvegicus	Or52e5	ENSRNOG00000073934
rattus_norvegicus		ENSRNOG00000084589

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409)

Protein

Protein identifiers

Olfactory receptor 52E5 — Q8NH55 (reviewed: Q8NH55)

All UniProt accessions (1): Q8NH55

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (1): NP_001005166* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (21 total): topological domain 8, transmembrane region 7, sequence variant 3, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH55-F1	82.81	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 99–191

Glycosylation sites (1): 5

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 15 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, chr11p15, GOBP_NERVOUS_SYSTEM_PROCESS

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

138 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52E5	RCAN2	Q14206	540
OR52E5	TDRD6	O60522	322
OR52E5	SLC25A27	O95847	279
OR52E5	CYP39A1	Q9NYL5	270
OR52E5	RHO	P08100	236
OR52E5	HBD	P02042	205
OR52E5	OR10D3	Q8NH80	202
OR52E5	OR6C75	A6NL08	197
OR52E5	OR9A4	Q8NGU2	197
OR52E5	OR3A1	P47881	192
OR52E5	PLA2G7	Q13093	189
OR52E5	SLC11A1	P49279	184
OR52E5	FNTA	P49354	166
OR52E5	EML1	O00423	166
OR52E5	HTR4	Q13639	166
OR52E5	HGSNAT	Q68CP4	166

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, O88628, P0C646, Q6IFG1, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGH6, Q8NGH7, Q8NGH9, Q8NGI0, Q8NGI2, Q8NGJ2, Q8NGJ3, Q8NGJ4, Q8NGJ5, Q8NGJ6, Q8NGJ7, Q8NGJ9, Q8NGK1, Q8NGK2, Q8NGK3, Q8NGK4, Q8NGK5, Q8NGK6, Q8NH53, Q8NH55, Q8NH56, Q8NH57, Q8NH59, Q8NH60, Q8NH61, Q8NH63, Q8NH64, Q8TCB6, Q8VBV9, Q96RD2, Q96RD3, Q9H255

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

103 predictions. Top by Δscore:

Variant	Effect	Δscore
11:5901427:T:G	acceptor_gain	0.8500
11:5901195:ACAAG:A	donor_loss	0.6600
11:5901196:CAAG:C	donor_loss	0.6600
11:5901197:AAG:A	donor_loss	0.6600
11:5901198:AG:A	donor_loss	0.6600
11:5901199:GGT:G	donor_loss	0.6600
11:5901200:GT:G	donor_loss	0.6600
11:5901201:T:A	donor_loss	0.6600
11:5901426:A:AG	acceptor_gain	0.6300
11:5901202:A:C	donor_loss	0.5800
11:5901426:AT:A	acceptor_gain	0.5800
11:5902062:T:G	acceptor_gain	0.5700
11:5900854:T:G	donor_gain	0.5600
11:5901432:A:AG	acceptor_gain	0.5400
11:5901433:G:GG	acceptor_gain	0.5400
11:5901428:GTCCA:G	acceptor_loss	0.5300
11:5901429:TCCAG:T	acceptor_loss	0.5300
11:5901430:CCAG:C	acceptor_loss	0.5300
11:5901431:CAGA:C	acceptor_loss	0.5300
11:5901432:A:AC	acceptor_loss	0.5300
11:5900882:GT:G	donor_gain	0.5000
11:5901427:T:TA	acceptor_gain	0.4900
11:5901823:T:G	acceptor_gain	0.4800
11:5901475:GCC:G	donor_gain	0.4200
11:5901030:G:T	donor_gain	0.4100
11:5901082:GAT:G	donor_gain	0.4100
11:5901200:G:GG	donor_gain	0.4100
11:5901350:GCC:G	donor_gain	0.4000
11:5900823:T:TA	donor_gain	0.3800
11:5900824:A:AA	donor_gain	0.3800

AlphaMissense

2154 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:5900960:T:C	F62L	0.836
11:5900962:T:A	F62L	0.836
11:5900962:T:G	F62L	0.836
11:5901284:T:C	F170L	0.832
11:5901286:C:A	F170L	0.832
11:5901286:C:G	F170L	0.832
11:5901563:T:C	F263L	0.780
11:5901565:T:A	F263L	0.780
11:5901565:T:G	F263L	0.780
11:5900816:T:C	F14L	0.765
11:5900818:C:A	F14L	0.765
11:5900818:C:G	F14L	0.765
11:5901062:T:C	F96L	0.742
11:5901064:T:A	F96L	0.742
11:5901064:T:G	F96L	0.742
11:5901524:T:C	F250L	0.709
11:5901526:C:A	F250L	0.709
11:5901526:C:G	F250L	0.709
11:5901548:T:C	F258L	0.688
11:5901550:C:A	F258L	0.688
11:5901550:C:G	F258L	0.688
11:5900873:T:C	F33L	0.666
11:5900875:C:A	F33L	0.666
11:5900875:C:G	F33L	0.666
11:5901035:T:C	F87L	0.658
11:5901037:C:A	F87L	0.658
11:5901037:C:G	F87L	0.658
11:5901542:T:C	F256L	0.648
11:5901544:T:A	F256L	0.648
11:5901544:T:G	F256L	0.648

dbSNP variants (sampled 300 via entrez): RS1000067384 (11:5891744 G>A,C), RS1000350310 (11:5892193 C>T), RS1000398718 (11:5891967 A>G), RS1000576034 (11:5898461 T>A), RS1001031647 (11:5898672 C>A,T), RS1001224438 (11:5903218 A>C), RS1001257111 (11:5902890 T>C), RS1001459580 (11:5899072 C>A,T), RS1001490525 (11:5898860 A>T), RS1001668639 (11:5893333 T>C), RS1001864518 (11:5893146 C>A), RS1001898631 (11:5892634 A>T), RS1002080642 (11:5898716 T>C), RS1002143515 (11:5893002 G>C), RS1002537796 (11:5899009 T>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
CGP 52608	affects binding, increases reaction	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.