OR52I2

Summary

OR52I2 (olfactory receptor family 52 subfamily I member 2, HGNC:15221) is a protein-coding gene on chromosome 11p15.4, encoding Olfactory receptor 52I2 (Q8NH67). Odorant receptor.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Source: NCBI Gene 143502 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 65 total
• MANE Select transcript: NM_001405760

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:15221
Approved symbol	OR52I2
Name	olfactory receptor family 52 subfamily I member 2
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000226288
Ensembl biotype	protein_coding
Entrez	143502

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000641486, ENST00000641896

RefSeq mRNA: 2 — MANE Select: NM_001405760 NM_001005170, NM_001405760

Canonical transcript exons

ENST00000641896 — 2 exons

Exon	Start	End
ENSE00003813967	4586872	4593340
ENSE00003814253	4581743	4581864

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 78.12.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.12	gold quality
sural nerve	UBERON:0015488	44.02	gold quality
granulocyte	CL:0000094	43.78	silver quality
bone marrow cell	CL:0002092	42.93	gold quality
skeletal muscle tissue	UBERON:0001134	41.18	gold quality
colonic epithelium	UBERON:0000397	41.06	gold quality
cortical plate	UBERON:0005343	39.78	gold quality
muscle tissue	UBERON:0002385	38.96	gold quality
vermiform appendix	UBERON:0001154	37.35	gold quality
monocyte	CL:0000576	37.33	gold quality
bone marrow	UBERON:0002371	37.27	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
tonsil	UBERON:0002372	36.44	gold quality
calcaneal tendon	UBERON:0003701	36.37	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	35.35	gold quality
apex of heart	UBERON:0002098	34.52	gold quality
cerebellum	UBERON:0002037	33.96	gold quality
cerebellar cortex	UBERON:0002129	33.85	gold quality
gall bladder	UBERON:0002110	33.71	silver quality
cerebellar hemisphere	UBERON:0002245	33.65	gold quality
liver	UBERON:0002107	33.36	gold quality
blood	UBERON:0000178	33.35	gold quality
right hemisphere of cerebellum	UBERON:0014890	32.89	gold quality
smooth muscle tissue	UBERON:0001135	32.45	gold quality
lymph node	UBERON:0000029	32.39	gold quality
urinary bladder	UBERON:0001255	31.85	gold quality
mucosa of stomach	UBERON:0001199	31.52	gold quality
prefrontal cortex	UBERON:0000451	31.24	gold quality
endometrium	UBERON:0001295	30.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.76

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): LHX2

Literature-anchored findings (GeneRIF, showing 1)

• This publication uses ‘GPR133’ as a name for this gene. (PMID:12732197)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Or52i2	ENSMUSG00000073969
rattus_norvegicus	Or52i2	ENSRNOG00000047148

Paralogs (51): OR51E2 (ENSG00000167332), OR51B5 (ENSG00000167355), OR51I1 (ENSG00000167359), OR51Q1 (ENSG00000167360), OR52A5 (ENSG00000171944), OR52W1 (ENSG00000175485), OR51B6 (ENSG00000176239), OR51V1 (ENSG00000176742), OR52E2 (ENSG00000176787), OR51L1 (ENSG00000176798), OR51G2 (ENSG00000176893), OR51A7 (ENSG00000176895), OR51T1 (ENSG00000176900), OR51S1 (ENSG00000176922), OR51F2 (ENSG00000176925), OR51E1 (ENSG00000180785), OR56B4 (ENSG00000180919), OR52E4 (ENSG00000180974), OR52N2 (ENSG00000180988), OR52N1 (ENSG00000181001), OR52N5 (ENSG00000181009), OR56B2 (ENSG00000181017), OR56B1 (ENSG00000181023), OR52N4 (ENSG00000181074), OR52P1 (ENSG00000181109), OR52D1 (ENSG00000181609), OR52H1 (ENSG00000181616), OR52K2 (ENSG00000181963), OR52A1 (ENSG00000182070), OR51B4 (ENSG00000183251), OR52E8 (ENSG00000183269), OR52L1 (ENSG00000183313), OR51M1 (ENSG00000184698), OR52B6 (ENSG00000187747), OR51I2 (ENSG00000187918), OR52K1 (ENSG00000196778), OR51D1 (ENSG00000197428), OR51C1 (ENSG00000197674), OR52M1 (ENSG00000197790), OR52E6 (ENSG00000205409)

Protein

Protein identifiers

Olfactory receptor 52I2 — Q8NH67 (reviewed: Q8NH67)

Alternative names: Olfactory receptor OR11-12

All UniProt accessions (1): A0A126GWK8

UniProt curated annotations — full annotation on UniProt →

Function. Odorant receptor.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (2): NP_001005170, NP_001392689* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR000725	Olfact_rcpt	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR050402	OR51/52/56-like	Family

Pfam: PF13853

UniProt features (23 total): topological domain 8, transmembrane region 7, sequence variant 5, chain 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NH67-F1	82.92	0.39

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 127–219

Glycosylation sites (1): 33

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9752946	Expression and translocation of olfactory receptors

MSigDB gene sets: 17 (showing top): GOBP_SENSORY_PERCEPTION_OF_CHEMICAL_STIMULUS, KEGG_OLFACTORY_TRANSDUCTION, GOBP_DETECTION_OF_STIMULUS, GOBP_SENSORY_PERCEPTION, GOMF_OLFACTORY_RECEPTOR_ACTIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, GOBP_SENSORY_PERCEPTION_OF_SMELL, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_DETECTION_OF_STIMULUS_INVOLVED_IN_SENSORY_PERCEPTION, REACTOME_OLFACTORY_SIGNALING_PATHWAY, REACTOME_SENSORY_PERCEPTION, GOBP_DETECTION_OF_CHEMICAL_STIMULUS, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, KONDO_PROSTATE_CANCER_WITH_H3K27ME3

GO Biological Process (5): signal transduction (GO:0007165), G protein-coupled receptor signaling pathway (GO:0007186), sensory perception of smell (GO:0007608), nervous system process (GO:0050877), detection of chemical stimulus involved in sensory perception of smell (GO:0050911)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), olfactory receptor activity (GO:0004984)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Olfactory Signaling Pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transmembrane signaling receptor activity	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
G protein-coupled receptor activity	1
signal transduction	1
sensory perception of chemical stimulus	1
system process	1
sensory perception of smell	1
detection of chemical stimulus involved in sensory perception	1
G protein-coupled receptor signaling pathway	1
detection of chemical stimulus involved in sensory perception of smell	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

218 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
OR52I2	Q12799	Q12799	422
OR52I2	VSIG10	Q8N0Z9	419
OR52I2	LLPH	Q9BRT6	391
OR52I2	CFAP52	Q8N1V2	374
OR52I2	AMER2	Q8N7J2	369
OR52I2	IGSF21	Q96ID5	348
OR52I2	OXCT2	Q9BYC2	348
OR52I2	ZC3HC1	Q86WB0	307
OR52I2	CNGA4	Q8IV77	303
OR52I2	SLC9B1	Q4ZJI4	300
OR52I2	TPST1	O60507	286
OR52I2	FAM221A	A4D161	271
OR52I2	IRAG2	Q12912	270
OR52I2	RHPN2	Q8IUC4	269
OR52I2	RSPH4A	Q5TD94	268

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A3B3IT45, A6NGY5, A6NMU1, B3DH96, O88628, P0C646, P0C7T3, Q5J3E5, Q5J3G9, Q5J3M9, Q5QD29, Q6IF63, Q6W049, Q8NGB9, Q8NGD3, Q8NGF0, Q8NGF1, Q8NGH6, Q8NGH7, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGJ4, Q8NGJ8, Q8NGJ9, Q8NGK5, Q8NGK6, Q8NGV6, Q8NH53, Q8NH55, Q8NH56, Q8NH60, Q8NH61, Q8NH63, Q8NH67, Q8NH76, Q8NHC6, Q8TCB6, Q8VBV9

Diamond homologs: A0A3B3IT45, A4D2G3, A6NF89, A6NGY5, A6NL08, A6NL26, A6NMU1, A6NND4, O88628, P0C629, P0C646, P0C7N1, P0C7T3, P23266, P23273, P23274, P30954, Q13606, Q60888, Q62007, Q6IF63, Q6IFG1, Q6W049, Q8NGA6, Q8NGF0, Q8NGF1, Q8NGF3, Q8NGG8, Q8NGH5, Q8NGH6, Q8NGH7, Q8NGH8, Q8NGH9, Q8NGI0, Q8NGI1, Q8NGI2, Q8NGI3, Q8NGI7, Q8NGJ2, Q8NGJ3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

227 predictions. Top by Δscore:

Variant	Effect	Δscore
11:4587133:G:GA	donor_gain	0.9500
11:4587142:GATG:G	donor_gain	0.9500
11:4587132:T:TA	donor_gain	0.9200
11:4587078:T:G	donor_gain	0.8200
11:4587134:G:GG	donor_gain	0.7600
11:4587146:G:GG	donor_gain	0.7300
11:4587067:GCA:G	donor_gain	0.7200
11:4587219:TAG:T	acceptor_gain	0.7000
11:4587146:GTG:G	donor_loss	0.6900
11:4587147:TGAG:T	donor_loss	0.6900
11:4587148:GAGC:G	donor_loss	0.6900
11:4587149:AG:A	donor_loss	0.6900
11:4587068:C:T	donor_gain	0.6800
11:4587135:TACCC:T	donor_gain	0.6800
11:4587136:ACCCA:A	donor_gain	0.6800
11:4587150:G:C	donor_loss	0.6800
11:4587220:A:AG	acceptor_gain	0.6700
11:4587221:G:GG	acceptor_gain	0.6700
11:4587218:TTAG:T	acceptor_gain	0.6600
11:4587220:AGCCA:A	acceptor_gain	0.5600
11:4587217:CTTAG:C	acceptor_gain	0.5300
11:4587221:G:T	acceptor_gain	0.4800
11:4587519:T:TA	acceptor_gain	0.4800
11:4587221:GCC:G	acceptor_gain	0.4400
11:4587851:AACCT:A	acceptor_gain	0.4300
11:4587329:GGAA:G	donor_gain	0.4200
11:4587664:T:TA	acceptor_gain	0.4100
11:4587786:T:G	acceptor_gain	0.4100
11:4587052:G:GT	donor_gain	0.4000
11:4587131:G:GT	donor_gain	0.4000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1002117392 (11:4587701 G>C), RS1002157434 (11:4586730 C>G,T), RS1002884881 (11:4585094 C>T), RS1002938694 (11:4585345 C>A,T), RS1005235514 (11:4585012 C>T), RS1007067395 (11:4588362 C>T), RS1008114423 (11:4587356 G>A), RS1009534829 (11:4586002 A>C), RS1010248443 (11:4585370 G>A,T), RS1010710816 (11:4585607 C>A,G,T), RS1011700624 (11:4587978 C>A,T), RS1011753148 (11:4588341 A>G,T), RS1012908309 (11:4585193 G>A), RS1013590235 (11:4588032 G>A), RS1013956577 (11:4586254 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002868_5	Response to serotonin reuptake inhibitors in major depressive disorder	2.000000e-06
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005658	response to selective serotonin reuptake inhibitor

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Resveratrol	affects cotreatment, decreases expression	2
Air Pollutants	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Copper	affects cotreatment, decreases expression	1
Plant Extracts	affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.